Glutamylation of Npm2 and Nap1 acidic disordered regions increases DNA mimicry and histone chaperone efficiency

Glutamylation of Npm2 and Nap1 acidic disordered regions increases DNA mimicry and histone chaperone efficiency

Summary: Histone chaperones–structurally diverse, non-catalytic proteins enriched with acidic intrinsically disordered regions (IDRs)–protect histones from spurious nucleic acid interactions and guide their deposition into and out of nucleosomes. Despite their conservation and ubiquity, the function...

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Bibliographic Details
Main Authors: Benjamin M. Lorton, Christopher Warren, Humaira Ilyas, Prithviraj Nandigrami, Subray Hegde, Sean Cahill, Stephanie M. Lehman, Jeffrey Shabanowitz, Donald F. Hunt, Andras Fiser, David Cowburn, David Shechter
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:iScience
Subjects:
Biological sciences
Molecular biology
Structural biology
Protein structure aspects
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224006795

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