Nanoformulations of natural products for management of metabolic syndrome
Yasamin Davatgaran Taghipour,1–3 Marziyeh Hajialyani,4 Rozita Naseri,5 Mahvash Hesari,6 Pantea Mohammadi,6 Azzurra Stefanucci,7 Adriano Mollica,7 Mohammad Hosein Farzaei,4,6 Mohammad Abdollahi81Department of Medical Nanotechnology, School of Advanced Medical Sciences, Tabriz Unive...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2019-07-01
|
| Series: | International Journal of Nanomedicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/nanoformulations-of-natural-products-for-management-of-metabolic-syndr-peer-reviewed-article-IJN |
| _version_ | 1831591207978926080 |
|---|---|
| author | Taghipour YD Hajialyani M Naseri R Hesari M Mohammadi P Stefanucci A Mollica A Farzaei MH Abdollahi M |
| author_facet | Taghipour YD Hajialyani M Naseri R Hesari M Mohammadi P Stefanucci A Mollica A Farzaei MH Abdollahi M |
| author_sort | Taghipour YD |
| collection | DOAJ |
| description | Yasamin Davatgaran Taghipour,1–3 Marziyeh Hajialyani,4 Rozita Naseri,5 Mahvash Hesari,6 Pantea Mohammadi,6 Azzurra Stefanucci,7 Adriano Mollica,7 Mohammad Hosein Farzaei,4,6 Mohammad Abdollahi81Department of Medical Nanotechnology, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; 2Phytopharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran; 3Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; 4Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; 5Internal Medicine Department, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran; 6Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran; 7Department of Pharmacy, G. d’Annunzio University of Chieti-pescara, Chieti 66100, Italy; 8Toxicology and Diseases Group, the Institute of Pharmaceutical Sciences (TIPS) and Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, IranAbstract: Metabolic syndrome is a common metabolic disorder which has become a public health challenge worldwide. There has been growing interest in medications including natural products as complementary or alternative choices for common chemical therapeutics regarding their limited side effects and ease of access. Nanosizing these compounds may help to increase their solubility, bioavailability, and promisingly enhance their efficacy. This study, for the first time, provides a comprehensive overview of the application of natural-products-based nanoformulations in the management of metabolic syndrome. Different phytochemicals including curcumin, berberine, Capsicum oleoresin, naringenin, emodin, gymnemic acid, resveratrol, quercetin, scutellarin, stevioside, silybin, baicalin, and others have been nanosized hitherto, and their nanosizing method and effect in treatment and alleviating metabolic syndrome have been reviewed and discussed in this study. It has been discovered that there are several pathways or molecular targets relevant to metabolic disorders which are affected by these compounds. Various natural-based nanoformulations have shown promising effect in treatment of metabolic syndrome, and therefore can be considered as future candidates instead of or in conjunction with pharmaceutical drugs if they pass clinical trials successfully.Keywords: nanoformulation, natural products, metabolic syndrome, diabetes |
| first_indexed | 2024-12-18T01:19:59Z |
| format | Article |
| id | doaj.art-308c5fc0c1ff478289d9cce5ccf40e25 |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-12-18T01:19:59Z |
| publishDate | 2019-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-308c5fc0c1ff478289d9cce5ccf40e252022-12-21T21:25:51ZengDove Medical PressInternational Journal of Nanomedicine1178-20132019-07-01Volume 145303532147165Nanoformulations of natural products for management of metabolic syndromeTaghipour YDHajialyani MNaseri RHesari MMohammadi PStefanucci AMollica AFarzaei MHAbdollahi MYasamin Davatgaran Taghipour,1–3 Marziyeh Hajialyani,4 Rozita Naseri,5 Mahvash Hesari,6 Pantea Mohammadi,6 Azzurra Stefanucci,7 Adriano Mollica,7 Mohammad Hosein Farzaei,4,6 Mohammad Abdollahi81Department of Medical Nanotechnology, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; 2Phytopharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran; 3Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; 4Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; 5Internal Medicine Department, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran; 6Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran; 7Department of Pharmacy, G. d’Annunzio University of Chieti-pescara, Chieti 66100, Italy; 8Toxicology and Diseases Group, the Institute of Pharmaceutical Sciences (TIPS) and Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, IranAbstract: Metabolic syndrome is a common metabolic disorder which has become a public health challenge worldwide. There has been growing interest in medications including natural products as complementary or alternative choices for common chemical therapeutics regarding their limited side effects and ease of access. Nanosizing these compounds may help to increase their solubility, bioavailability, and promisingly enhance their efficacy. This study, for the first time, provides a comprehensive overview of the application of natural-products-based nanoformulations in the management of metabolic syndrome. Different phytochemicals including curcumin, berberine, Capsicum oleoresin, naringenin, emodin, gymnemic acid, resveratrol, quercetin, scutellarin, stevioside, silybin, baicalin, and others have been nanosized hitherto, and their nanosizing method and effect in treatment and alleviating metabolic syndrome have been reviewed and discussed in this study. It has been discovered that there are several pathways or molecular targets relevant to metabolic disorders which are affected by these compounds. Various natural-based nanoformulations have shown promising effect in treatment of metabolic syndrome, and therefore can be considered as future candidates instead of or in conjunction with pharmaceutical drugs if they pass clinical trials successfully.Keywords: nanoformulation, natural products, metabolic syndrome, diabeteshttps://www.dovepress.com/nanoformulations-of-natural-products-for-management-of-metabolic-syndr-peer-reviewed-article-IJNnanoformulationsnatural productsmetabolic syndromediabetes |
| spellingShingle | Taghipour YD Hajialyani M Naseri R Hesari M Mohammadi P Stefanucci A Mollica A Farzaei MH Abdollahi M Nanoformulations of natural products for management of metabolic syndrome International Journal of Nanomedicine nanoformulations natural products metabolic syndrome diabetes |
| title | Nanoformulations of natural products for management of metabolic syndrome |
| title_full | Nanoformulations of natural products for management of metabolic syndrome |
| title_fullStr | Nanoformulations of natural products for management of metabolic syndrome |
| title_full_unstemmed | Nanoformulations of natural products for management of metabolic syndrome |
| title_short | Nanoformulations of natural products for management of metabolic syndrome |
| title_sort | nanoformulations of natural products for management of metabolic syndrome |
| topic | nanoformulations natural products metabolic syndrome diabetes |
| url | https://www.dovepress.com/nanoformulations-of-natural-products-for-management-of-metabolic-syndr-peer-reviewed-article-IJN |
| work_keys_str_mv | AT taghipouryd nanoformulationsofnaturalproductsformanagementofmetabolicsyndrome AT hajialyanim nanoformulationsofnaturalproductsformanagementofmetabolicsyndrome AT naserir nanoformulationsofnaturalproductsformanagementofmetabolicsyndrome AT hesarim nanoformulationsofnaturalproductsformanagementofmetabolicsyndrome AT mohammadip nanoformulationsofnaturalproductsformanagementofmetabolicsyndrome AT stefanuccia nanoformulationsofnaturalproductsformanagementofmetabolicsyndrome AT mollicaa nanoformulationsofnaturalproductsformanagementofmetabolicsyndrome AT farzaeimh nanoformulationsofnaturalproductsformanagementofmetabolicsyndrome AT abdollahim nanoformulationsofnaturalproductsformanagementofmetabolicsyndrome |