An overview of animal prion diseases
<p>Abstract</p> <p>Prion diseases are transmissible neurodegenerative conditions affecting human and a wide range of animal species. The pathogenesis of prion diseases is associated with the accumulation of aggregates of misfolded conformers of host-encoded cellular prion protein (...
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| Format: | Article |
| Language: | English |
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BMC
2011-11-01
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| Series: | Virology Journal |
| Subjects: | |
| Online Access: | http://www.virologyj.com/content/8/1/493 |
| _version_ | 1811278470388383744 |
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| author | Imran Muhammad Mahmood Saqib |
| author_facet | Imran Muhammad Mahmood Saqib |
| author_sort | Imran Muhammad |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Prion diseases are transmissible neurodegenerative conditions affecting human and a wide range of animal species. The pathogenesis of prion diseases is associated with the accumulation of aggregates of misfolded conformers of host-encoded cellular prion protein (PrP<sup>C</sup>). Animal prion diseases include scrapie of sheep and goats, bovine spongiform encephalopathy (BSE) or mad cow disease, transmissible mink encephalopathy, feline spongiform encephalopathy, exotic ungulate spongiform encephalopathy, chronic wasting disease of cervids and spongiform encephalopathy of primates. Although some cases of sporadic atypical scrapie and BSE have also been reported, animal prion diseases have basically occurred via the acquisition of infection from contaminated feed or via the exposure to contaminated environment. Scrapie and chronic wasting disease are naturally sustaining epidemics. The transmission of BSE to human has caused more than 200 cases of variant Cruetzfeldt-Jacob disease and has raised serious public health concerns. The present review discusses the epidemiology, clinical neuropathology, transmissibility and genetics of animal prion diseases.</p> |
| first_indexed | 2024-04-13T00:35:20Z |
| format | Article |
| id | doaj.art-308c7aa2930341bea14c090ab98aaf4e |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-04-13T00:35:20Z |
| publishDate | 2011-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-308c7aa2930341bea14c090ab98aaf4e2022-12-22T03:10:20ZengBMCVirology Journal1743-422X2011-11-018149310.1186/1743-422X-8-493An overview of animal prion diseasesImran MuhammadMahmood Saqib<p>Abstract</p> <p>Prion diseases are transmissible neurodegenerative conditions affecting human and a wide range of animal species. The pathogenesis of prion diseases is associated with the accumulation of aggregates of misfolded conformers of host-encoded cellular prion protein (PrP<sup>C</sup>). Animal prion diseases include scrapie of sheep and goats, bovine spongiform encephalopathy (BSE) or mad cow disease, transmissible mink encephalopathy, feline spongiform encephalopathy, exotic ungulate spongiform encephalopathy, chronic wasting disease of cervids and spongiform encephalopathy of primates. Although some cases of sporadic atypical scrapie and BSE have also been reported, animal prion diseases have basically occurred via the acquisition of infection from contaminated feed or via the exposure to contaminated environment. Scrapie and chronic wasting disease are naturally sustaining epidemics. The transmission of BSE to human has caused more than 200 cases of variant Cruetzfeldt-Jacob disease and has raised serious public health concerns. The present review discusses the epidemiology, clinical neuropathology, transmissibility and genetics of animal prion diseases.</p>http://www.virologyj.com/content/8/1/493Prion diseasesscrapieBSEchronic wasting disease<it>PRNP</it> |
| spellingShingle | Imran Muhammad Mahmood Saqib An overview of animal prion diseases Virology Journal Prion diseases scrapie BSE chronic wasting disease <it>PRNP</it> |
| title | An overview of animal prion diseases |
| title_full | An overview of animal prion diseases |
| title_fullStr | An overview of animal prion diseases |
| title_full_unstemmed | An overview of animal prion diseases |
| title_short | An overview of animal prion diseases |
| title_sort | overview of animal prion diseases |
| topic | Prion diseases scrapie BSE chronic wasting disease <it>PRNP</it> |
| url | http://www.virologyj.com/content/8/1/493 |
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