Feline Oral Squamous Cell Carcinoma: A Critical Review of Etiologic Factors
Feline oral squamous cell carcinoma (FOSCC) is the most common oral neoplasia in cats. This malignant tumor is locally invasive, has a high mortality rate, and its etiology is not yet known. In humans, head and neck squamous cell carcinoma is associated with tobacco smoke, alcohol consumption, and h...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/9/10/558 |
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| author | Inês Sequeira Maria dos Anjos Pires José Leitão Joaquim Henriques Carlos Viegas João Requicha |
| author_facet | Inês Sequeira Maria dos Anjos Pires José Leitão Joaquim Henriques Carlos Viegas João Requicha |
| author_sort | Inês Sequeira |
| collection | DOAJ |
| description | Feline oral squamous cell carcinoma (FOSCC) is the most common oral neoplasia in cats. This malignant tumor is locally invasive, has a high mortality rate, and its etiology is not yet known. In humans, head and neck squamous cell carcinoma is associated with tobacco smoke, alcohol consumption, and human papillomavirus infection. Herein, a critical review about the potential etiologic factors of FOSCC was performed, considering publications between 2000 and 2022, aiming to synthesize all available scientific evidence regarding this issue. Recommendations of the PRISMA statement and the Cochrane Collaboration were followed and the PubMed database searched by using the MeSH terms MeSH terms “oral”, “mouth”, “lingual”, “labial”, “gingiva”, “carcinoma”, “squamous”, and “feline”. The selection process for eligible studies was based on specific inclusion and exclusion criteria and the quality of the studies assessed. The initial search resulted in 553 publications, with only 26 of these being included in the review. Sixteen studies were related to viral etiology and nine related to environmental factors such as exposure to tobacco smoke, ectoparasitic products, and the presence of oral comorbidities. When evaluated, feline papillomavirus was detected in 16.2% of samples of FOSCC. In the three studies focused on exposure to tobacco smoke, 35.2% (30/85) of cats with FOSCC had a history of this exposure. The consumption of canned food and the use of deworming collars were associated, in only one publication, with a risk of neoplasia increased by 4.7 and 5.3 times, respectively. Among 485 cats with FOSCC, 6.4% had dental and oral pathology (i.e., periodontal disease or feline chronic gingivostomatitis). The present study demonstrates that the available evidence on the etiology of FOSCC is still limited, however, there has been an increasing interest on this topic. To better understand the role of the possible etiological factors of this aggressive disease, and model for its human counterpart, large, prospective multi-institutional studies are needed. |
| first_indexed | 2024-03-09T19:23:46Z |
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| id | doaj.art-308cb6d4354a44fd8dc14697dbd08a84 |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-09T19:23:46Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-308cb6d4354a44fd8dc14697dbd08a842023-11-24T03:06:40ZengMDPI AGVeterinary Sciences2306-73812022-10-0191055810.3390/vetsci9100558Feline Oral Squamous Cell Carcinoma: A Critical Review of Etiologic FactorsInês Sequeira0Maria dos Anjos Pires1José Leitão2Joaquim Henriques3Carlos Viegas4João Requicha5Department of Veterinary Sciences, University of Trás-os-Montes e Alto Douro, 5000-801 Vila Real, PortugalDepartment of Veterinary Sciences, University of Trás-os-Montes e Alto Douro, 5000-801 Vila Real, PortugalDepartment of Sport, Exercise and Health Sciences, University of Trás-os-Montes e Alto Douro, 5000-801 Vila Real, PortugalOncology Service, Centre Hospitalière Vétérinaire Frégis, 94110 Arcueil, FranceDepartment of Veterinary Sciences, University of Trás-os-Montes e Alto Douro, 5000-801 Vila Real, PortugalDepartment of Veterinary Sciences, University of Trás-os-Montes e Alto Douro, 5000-801 Vila Real, PortugalFeline oral squamous cell carcinoma (FOSCC) is the most common oral neoplasia in cats. This malignant tumor is locally invasive, has a high mortality rate, and its etiology is not yet known. In humans, head and neck squamous cell carcinoma is associated with tobacco smoke, alcohol consumption, and human papillomavirus infection. Herein, a critical review about the potential etiologic factors of FOSCC was performed, considering publications between 2000 and 2022, aiming to synthesize all available scientific evidence regarding this issue. Recommendations of the PRISMA statement and the Cochrane Collaboration were followed and the PubMed database searched by using the MeSH terms MeSH terms “oral”, “mouth”, “lingual”, “labial”, “gingiva”, “carcinoma”, “squamous”, and “feline”. The selection process for eligible studies was based on specific inclusion and exclusion criteria and the quality of the studies assessed. The initial search resulted in 553 publications, with only 26 of these being included in the review. Sixteen studies were related to viral etiology and nine related to environmental factors such as exposure to tobacco smoke, ectoparasitic products, and the presence of oral comorbidities. When evaluated, feline papillomavirus was detected in 16.2% of samples of FOSCC. In the three studies focused on exposure to tobacco smoke, 35.2% (30/85) of cats with FOSCC had a history of this exposure. The consumption of canned food and the use of deworming collars were associated, in only one publication, with a risk of neoplasia increased by 4.7 and 5.3 times, respectively. Among 485 cats with FOSCC, 6.4% had dental and oral pathology (i.e., periodontal disease or feline chronic gingivostomatitis). The present study demonstrates that the available evidence on the etiology of FOSCC is still limited, however, there has been an increasing interest on this topic. To better understand the role of the possible etiological factors of this aggressive disease, and model for its human counterpart, large, prospective multi-institutional studies are needed.https://www.mdpi.com/2306-7381/9/10/558catoral cavitysquamous cell carcinomacritical reviewetiologypapillomavirus |
| spellingShingle | Inês Sequeira Maria dos Anjos Pires José Leitão Joaquim Henriques Carlos Viegas João Requicha Feline Oral Squamous Cell Carcinoma: A Critical Review of Etiologic Factors Veterinary Sciences cat oral cavity squamous cell carcinoma critical review etiology papillomavirus |
| title | Feline Oral Squamous Cell Carcinoma: A Critical Review of Etiologic Factors |
| title_full | Feline Oral Squamous Cell Carcinoma: A Critical Review of Etiologic Factors |
| title_fullStr | Feline Oral Squamous Cell Carcinoma: A Critical Review of Etiologic Factors |
| title_full_unstemmed | Feline Oral Squamous Cell Carcinoma: A Critical Review of Etiologic Factors |
| title_short | Feline Oral Squamous Cell Carcinoma: A Critical Review of Etiologic Factors |
| title_sort | feline oral squamous cell carcinoma a critical review of etiologic factors |
| topic | cat oral cavity squamous cell carcinoma critical review etiology papillomavirus |
| url | https://www.mdpi.com/2306-7381/9/10/558 |
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