Whole transcriptome analysis of human erythropoietic cells during ontogenesis suggests a role of VEGFA gene as modulator of fetal hemoglobin and pharmacogenomic biomarker of treatment response to hydroxyurea in β-type hemoglobinopathy patients

Whole transcriptome analysis of human erythropoietic cells during ontogenesis suggests a role of VEGFA gene as modulator of fetal hemoglobin and pharmacogenomic biomarker of treatment response to hydroxyurea in β-type hemoglobinopathy patients

Abstract Background Human erythropoiesis is characterized by distinct gene expression profiles at various developmental stages. Previous studies suggest that fetal-to-adult hemoglobin switch is regulated by a complex mechanism, in which many key players still remain unknown. Here, we report our find...

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Bibliographic Details
Main Authors: Vasiliki Chondrou, Petros Kolovos, Argyro Sgourou, Alexandra Kourakli, Alexia Pavlidaki, Vlasia Kastrinou, Anne John, Argiris Symeonidis, Bassam R. Ali, Adamantia Papachatzopoulou, Theodora Katsila, George P. Patrinos
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Human Genomics
Subjects:
VEGFA
Beta-thalassemia
Transcriptomics
Ontogenesis
Sickle cell disease
Erythroid cell differentiation
Online Access:http://link.springer.com/article/10.1186/s40246-017-0120-8

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http://link.springer.com/article/10.1186/s40246-017-0120-8

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