Prevalence of dyslipidemia in adult Indian diabetic patients: A cross sectional study (SOLID)
Context: India leads the world with largest number of diabetic patients and is often referred to as the diabetes capital of the world. Diabetic dyslipidemia in India is one of the main cause for Coronary Artery Disease (CAD) mortality. Although diabetes continues to be a major lifestyle condition in...
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
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| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2014;volume=18;issue=5;spage=642;epage=647;aulast=Mithal |
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| author | Ambrish Mithal Debashish Majhi M Shunmugavelu Pradeep G Talwarkar Hardik Vasnawala Ammar S Raza |
| author_facet | Ambrish Mithal Debashish Majhi M Shunmugavelu Pradeep G Talwarkar Hardik Vasnawala Ammar S Raza |
| author_sort | Ambrish Mithal |
| collection | DOAJ |
| description | Context: India leads the world with largest number of diabetic patients and is often referred to as the diabetes capital of the world. Diabetic dyslipidemia in India is one of the main cause for Coronary Artery Disease (CAD) mortality. Although diabetes continues to be a major lifestyle condition in India, there is a lack of studies in India on whether dyslipidemia in Indian diabetics is being adequately controlled. Our study provides critical insights into the insights into proportion of diabetes patients achieving lipid goal in India. Aims: The primary objective of our study was to assess the control of dyslipidemia in the Indian diabetic population treated with lipid lowering drugs (LLDs), as per American Diabetes Association (ADA) 2010 guidelines. Settings and Design: The study was carried out in a real world Indian clinical setting involving 178 sites. This is a multicenter, noninterventional, and cross-sectional observational study. Materials and Methods: A total of 5400 adult subjects with established type-2 diabetes mellitus (T2DM) and dyslipidemia were recruited for the study. Patients in the study were on LLD at a stable dose for at least last 3 months before the designated study visit. Routine lipid profile tests were conducted for all patients. Statistical Analysis Used: Descriptive statistics was used to analyze qualitative and discrete variables. Chi-square test and t-test were conducted to assess the existence of statistically significant association between the variables. Results: A total of 5400 patients with T2DM from 178 centers across India were recruited. Out of the total population, 56.75% (N = 3065) of them were males. Primary end-point of low-density lipoprotein cholesterol (LDL-C) level below ADA 2010 target was achieved in a total of 48.74% (N = 2632) patients. Gender was significantly associated with lipid levels and age was significantly (P < 0.05) correlated with all lipid levels. Control rates of other lipid parameters like high-density lipoprotein cholesterol, triglyceride, and total cholesterol in the study were 60.48% (N = 3236), 57.54% (N = 3107), and 92.24% (N = 4981) respectively. Among those with overt cardiovascular disease (CVD), target LDL-C level of < 70 mg/dL was achieved in 22.87% (70 out of 306) patients. The LDL-C levels of 49.03% (N = 1768) patients who were on statin therapy were within target levels, while 53.46% (N = 634) patients who were on statin and their combinations with other LLDs had their LDL-C levels within the stipulated range. Conclusions: This study has reveled that dyslipidemia control in Indian T2DM patients is very poor with almost half of them not reaching their LDL -C goal. Dyslipidemia being one of the main risk factors for CVD in T2DM patients there is a need to treat dyslipidemia aggressively to reduce risk of future CV events. |
| first_indexed | 2024-12-22T17:16:06Z |
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| issn | 2230-8210 2230-9500 |
| language | English |
| last_indexed | 2024-12-22T17:16:06Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
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| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-30919d63622440f3a5356ce83408fa572022-12-21T18:18:57ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002014-01-0118564264710.4103/2230-8210.139220Prevalence of dyslipidemia in adult Indian diabetic patients: A cross sectional study (SOLID)Ambrish MithalDebashish MajhiM ShunmugaveluPradeep G TalwarkarHardik VasnawalaAmmar S RazaContext: India leads the world with largest number of diabetic patients and is often referred to as the diabetes capital of the world. Diabetic dyslipidemia in India is one of the main cause for Coronary Artery Disease (CAD) mortality. Although diabetes continues to be a major lifestyle condition in India, there is a lack of studies in India on whether dyslipidemia in Indian diabetics is being adequately controlled. Our study provides critical insights into the insights into proportion of diabetes patients achieving lipid goal in India. Aims: The primary objective of our study was to assess the control of dyslipidemia in the Indian diabetic population treated with lipid lowering drugs (LLDs), as per American Diabetes Association (ADA) 2010 guidelines. Settings and Design: The study was carried out in a real world Indian clinical setting involving 178 sites. This is a multicenter, noninterventional, and cross-sectional observational study. Materials and Methods: A total of 5400 adult subjects with established type-2 diabetes mellitus (T2DM) and dyslipidemia were recruited for the study. Patients in the study were on LLD at a stable dose for at least last 3 months before the designated study visit. Routine lipid profile tests were conducted for all patients. Statistical Analysis Used: Descriptive statistics was used to analyze qualitative and discrete variables. Chi-square test and t-test were conducted to assess the existence of statistically significant association between the variables. Results: A total of 5400 patients with T2DM from 178 centers across India were recruited. Out of the total population, 56.75% (N = 3065) of them were males. Primary end-point of low-density lipoprotein cholesterol (LDL-C) level below ADA 2010 target was achieved in a total of 48.74% (N = 2632) patients. Gender was significantly associated with lipid levels and age was significantly (P < 0.05) correlated with all lipid levels. Control rates of other lipid parameters like high-density lipoprotein cholesterol, triglyceride, and total cholesterol in the study were 60.48% (N = 3236), 57.54% (N = 3107), and 92.24% (N = 4981) respectively. Among those with overt cardiovascular disease (CVD), target LDL-C level of < 70 mg/dL was achieved in 22.87% (70 out of 306) patients. The LDL-C levels of 49.03% (N = 1768) patients who were on statin therapy were within target levels, while 53.46% (N = 634) patients who were on statin and their combinations with other LLDs had their LDL-C levels within the stipulated range. Conclusions: This study has reveled that dyslipidemia control in Indian T2DM patients is very poor with almost half of them not reaching their LDL -C goal. Dyslipidemia being one of the main risk factors for CVD in T2DM patients there is a need to treat dyslipidemia aggressively to reduce risk of future CV events.http://www.ijem.in/article.asp?issn=2230-8210;year=2014;volume=18;issue=5;spage=642;epage=647;aulast=MithalCVDdiabetesdyslipidemiaLDL |
| spellingShingle | Ambrish Mithal Debashish Majhi M Shunmugavelu Pradeep G Talwarkar Hardik Vasnawala Ammar S Raza Prevalence of dyslipidemia in adult Indian diabetic patients: A cross sectional study (SOLID) Indian Journal of Endocrinology and Metabolism CVD diabetes dyslipidemia LDL |
| title | Prevalence of dyslipidemia in adult Indian diabetic patients: A cross sectional study (SOLID) |
| title_full | Prevalence of dyslipidemia in adult Indian diabetic patients: A cross sectional study (SOLID) |
| title_fullStr | Prevalence of dyslipidemia in adult Indian diabetic patients: A cross sectional study (SOLID) |
| title_full_unstemmed | Prevalence of dyslipidemia in adult Indian diabetic patients: A cross sectional study (SOLID) |
| title_short | Prevalence of dyslipidemia in adult Indian diabetic patients: A cross sectional study (SOLID) |
| title_sort | prevalence of dyslipidemia in adult indian diabetic patients a cross sectional study solid |
| topic | CVD diabetes dyslipidemia LDL |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2014;volume=18;issue=5;spage=642;epage=647;aulast=Mithal |
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