ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania major.

ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania major.

Macroautophagy has been shown to be important for the cellular remodelling required for Leishmania differentiation. We now demonstrate that L. major contains a functional ATG12-ATG5 conjugation system, which is required for ATG8-dependent autophagosome formation. Nascent autophagosomes were found co...

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Bibliographic Details
Main Authors: Roderick A M Williams, Terry K Smith, Benjamin Cull, Jeremy C Mottram, Graham H Coombs
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3355087?pdf=render

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