Myeloma-derived IL-32γ induced PD-L1 expression in macrophages facilitates immune escape via the PFKFB3-JAK1 axis

Myeloma-derived IL-32γ induced PD-L1 expression in macrophages facilitates immune escape via the PFKFB3-JAK1 axis

Multiple myeloma (MM) is characterized by an accumulation of monoclonal plasma cells within the bone marrow (BM). Macrophages are an abundant component of myeloma BM microenvironment and support survival of the malignant cells and foster myeloma development and progression by suppression of the immu...

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Bibliographic Details
Main Authors: Yang Liu, Haimeng Yan, Huiyao Gu, Enfan Zhang, Jingsong He, Wen Cao, Jianwei Qu, Ruyi Xu, Liqin Cao, Donghua He, Jinna Zhang, Yifan Hou, Zhen Cai
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:OncoImmunology
Subjects:
Multiple myeloma
IL-32
macrophage
glycolysis
immune checkpoint
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2022.2057837

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