Risk factors for the long-term prognosis and recurrence of HIV-negative cytomegalovirus retinitis in North China
AIM: To demonstrate the clinical features, the risk factors, the visual prognosis and the recurrence of cytomegalovirus (CMV) retinitis (CMVR) in HIV-negative patients. METHODS: HIV-negative patients with CMVR were involved in this study. Best corrected visual acuity (BCVA), intraocular pressure (IO...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2022-10-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://ies.ijo.cn/en_publish/2022/10/20221011.pdf |
| _version_ | 1828242832636248064 |
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| author | Yan-Hong Shi Hui Wang Hao Kang Jing Feng Xiao-Feng Hu Yun Li Zhu-Yun Qian Yong Tao |
| author_facet | Yan-Hong Shi Hui Wang Hao Kang Jing Feng Xiao-Feng Hu Yun Li Zhu-Yun Qian Yong Tao |
| author_sort | Yan-Hong Shi |
| collection | DOAJ |
| description | AIM: To demonstrate the clinical features, the risk factors, the visual prognosis and the recurrence of cytomegalovirus (CMV) retinitis (CMVR) in HIV-negative patients. METHODS: HIV-negative patients with CMVR were involved in this study. Best corrected visual acuity (BCVA), intraocular pressure (IOP), CMV-DNA load in aqueous and/or serum samples, treatment, follow-up time, recurrence and complications were recorded. Ocular characteristics were evaluated by fundus photographs. Association between ocular factors and visual prognosis were analyzed by regression analysis. RESULTS: Twenty-five eyes of 16 patients were included. All 25 eyes underwent intravitreal injections of anti-viral agents. The mean logMAR BCVA improved from 0.94±0.98 (0.98-0.78) initially to 0.77±0.73 (0.82-0.68) at last visit, but not significantly. After antiviral treatment, the aqueous CMV DNA load significantly reduced to (3.42±1.47)×102 copies/mL (P=0.001), compared with (2.51±3.11)×105 copies/mL at baseline. Macular involvement (R2=0.475, P=0.049) and initial visual acuity (R2=0.475, P=0.017) were significantly associated with the poor visual prognosis (BCVA<20/400). The extent of retinal lesions (R2=0.064, P=0.04) was significant associated with the risk of recurrence of CMVR. CONCLUSION: Intravitreal injection of anti-viral agents offers a safe and effective treatment for CMVR. Macular involvement and initial visual acuity significantly associate with visual prognosis. The extent of retinal lesions is significantly associated with the recurrence of CMVR. These ocular factors can be used as predictive risk factors for long term visual prognosis in HIV-negative CMVR patients. |
| first_indexed | 2024-04-12T22:21:32Z |
| format | Article |
| id | doaj.art-3096ce759f2a4baf81adfa3576d55d0a |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-04-12T22:21:32Z |
| publishDate | 2022-10-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-3096ce759f2a4baf81adfa3576d55d0a2022-12-22T03:14:19ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982022-10-0115101634164010.18240/ijo.2022.10.1120221011Risk factors for the long-term prognosis and recurrence of HIV-negative cytomegalovirus retinitis in North ChinaYan-Hong Shi0Hui Wang1Hao Kang2Jing Feng3Xiao-Feng Hu4Yun Li5Zhu-Yun Qian6Yong Tao7Zhu-Yun Qian. Beijing GIANTMED Medical Diagnostics Lab, No.37, Lanxi Park, Renhe Town, Shunyi District, Beijing 101300, China. qianzhuyun552@126.com; Yong Tao. Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, No.8, South Road of Worker's Stadium, Chaoyang District, Beijing 100020, China. taoyong@bjcyh.comDepartment of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaDepartment of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaDepartment of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaDepartment of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaZhantansi Outpatient Department, Jing Zhong Medical Area, Chinese PLA General Hospital, Beijing 100853, ChinaBeijing GIANTMED Medical Diagnostics Lab, Beijing 101300, ChinaDepartment of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaAIM: To demonstrate the clinical features, the risk factors, the visual prognosis and the recurrence of cytomegalovirus (CMV) retinitis (CMVR) in HIV-negative patients. METHODS: HIV-negative patients with CMVR were involved in this study. Best corrected visual acuity (BCVA), intraocular pressure (IOP), CMV-DNA load in aqueous and/or serum samples, treatment, follow-up time, recurrence and complications were recorded. Ocular characteristics were evaluated by fundus photographs. Association between ocular factors and visual prognosis were analyzed by regression analysis. RESULTS: Twenty-five eyes of 16 patients were included. All 25 eyes underwent intravitreal injections of anti-viral agents. The mean logMAR BCVA improved from 0.94±0.98 (0.98-0.78) initially to 0.77±0.73 (0.82-0.68) at last visit, but not significantly. After antiviral treatment, the aqueous CMV DNA load significantly reduced to (3.42±1.47)×102 copies/mL (P=0.001), compared with (2.51±3.11)×105 copies/mL at baseline. Macular involvement (R2=0.475, P=0.049) and initial visual acuity (R2=0.475, P=0.017) were significantly associated with the poor visual prognosis (BCVA<20/400). The extent of retinal lesions (R2=0.064, P=0.04) was significant associated with the risk of recurrence of CMVR. CONCLUSION: Intravitreal injection of anti-viral agents offers a safe and effective treatment for CMVR. Macular involvement and initial visual acuity significantly associate with visual prognosis. The extent of retinal lesions is significantly associated with the recurrence of CMVR. These ocular factors can be used as predictive risk factors for long term visual prognosis in HIV-negative CMVR patients.http://ies.ijo.cn/en_publish/2022/10/20221011.pdfcytomegalovirus retinitisaqueous humorvisual acuityrisk factorsrecurrence |
| spellingShingle | Yan-Hong Shi Hui Wang Hao Kang Jing Feng Xiao-Feng Hu Yun Li Zhu-Yun Qian Yong Tao Risk factors for the long-term prognosis and recurrence of HIV-negative cytomegalovirus retinitis in North China International Journal of Ophthalmology cytomegalovirus retinitis aqueous humor visual acuity risk factors recurrence |
| title | Risk factors for the long-term prognosis and recurrence of HIV-negative cytomegalovirus retinitis in North China |
| title_full | Risk factors for the long-term prognosis and recurrence of HIV-negative cytomegalovirus retinitis in North China |
| title_fullStr | Risk factors for the long-term prognosis and recurrence of HIV-negative cytomegalovirus retinitis in North China |
| title_full_unstemmed | Risk factors for the long-term prognosis and recurrence of HIV-negative cytomegalovirus retinitis in North China |
| title_short | Risk factors for the long-term prognosis and recurrence of HIV-negative cytomegalovirus retinitis in North China |
| title_sort | risk factors for the long term prognosis and recurrence of hiv negative cytomegalovirus retinitis in north china |
| topic | cytomegalovirus retinitis aqueous humor visual acuity risk factors recurrence |
| url | http://ies.ijo.cn/en_publish/2022/10/20221011.pdf |
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