MR findings of primary ovarian granulosa cell tumor with focus on the differentiation with other ovarian sex cord-stromal tumors
Abstract Background To describe magnetic resonance imaging (MRI) features of ovarian granulosa cell tumors (OGCTs) and compare with other sex cord-stromal tumors (OSCs) in ovary. Methods MR findings of 18 patients with surgically confirmed ovarian granulosa cell tumor were retrospectively reviewed b...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-06-01
|
| Series: | Journal of Ovarian Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13048-018-0416-x |
| _version_ | 1797967703568285696 |
|---|---|
| author | He Zhang Hongyu Zhang Shouxin Gu Yanyu Zhang Xuefen Liu Guofu Zhang |
| author_facet | He Zhang Hongyu Zhang Shouxin Gu Yanyu Zhang Xuefen Liu Guofu Zhang |
| author_sort | He Zhang |
| collection | DOAJ |
| description | Abstract Background To describe magnetic resonance imaging (MRI) features of ovarian granulosa cell tumors (OGCTs) and compare with other sex cord-stromal tumors (OSCs) in ovary. Methods MR findings of 18 patients with surgically confirmed ovarian granulosa cell tumor were retrospectively reviewed by two radiologists with consensus reading. All MR examinations were prospectively performed within one month. Clinical and imaging characteristics of OGCTs were evaluated and compared with OSCs (control group). Results In 18 patients, 20 ovarian granulosa cell tumors were detected on MRI. Sixteen tumors appeared as solid or mostly solid mass (16/20), while 4 tumors as cystic mass. Pathological pelvic fluid was detected in 1 OGCT (1/18) and 11 OSCs (11/34) (p = 0.031).On T2 weighted imaging (T2WI), most of OGCTs displayed hyperintense signal and mixed signal (19/20); on T1 weighted imaging (T1WI), 11 OGCTs (11/20) displayed similar signal as on T2WI imaging. The lesion signal between OGCT and OSC differed significantly on both T1WI (p = 0.017) and T2WI (p = 0.002). Tumoral bleeding was detected in 6 OGCTs on MRI. On diffusion weighted imaging (DWI) images, OGCTs mostly appeared as high signal (16/20). Average apparent diffusion coefficient (ADC) value derived from DWI images in the OGCT group (0.84 ± 0.26× 10− 3 mm2/s was less than the control group (1.22 ± 0.47 × 10− 3 mm2/s) with statistical difference (p = 0.002). Conclusions MRI could provide important information in OGCT diagnosis. ADC value might be useful in differentiating OGCT from OSC. |
| first_indexed | 2024-04-11T02:34:18Z |
| format | Article |
| id | doaj.art-3097885a7bbc482e8314d8a4114580c1 |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-11T02:34:18Z |
| publishDate | 2018-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-3097885a7bbc482e8314d8a4114580c12023-01-02T20:26:25ZengBMCJournal of Ovarian Research1757-22152018-06-011111910.1186/s13048-018-0416-xMR findings of primary ovarian granulosa cell tumor with focus on the differentiation with other ovarian sex cord-stromal tumorsHe Zhang0Hongyu Zhang1Shouxin Gu2Yanyu Zhang3Xuefen Liu4Guofu Zhang5Department of Radiology, Obstetrics and Gynecology Hospital, Fudan UniversityDepartment of Ultrasound, Daqing Oilfield General HospitalDepartment of Radiology, Obstetrics and Gynecology Hospital, Fudan UniversityDepartment of Radiology, Obstetrics and Gynecology Hospital, Fudan UniversityDepartment of Radiology, Obstetrics and Gynecology Hospital, Fudan UniversityDepartment of Radiology, Obstetrics and Gynecology Hospital, Fudan UniversityAbstract Background To describe magnetic resonance imaging (MRI) features of ovarian granulosa cell tumors (OGCTs) and compare with other sex cord-stromal tumors (OSCs) in ovary. Methods MR findings of 18 patients with surgically confirmed ovarian granulosa cell tumor were retrospectively reviewed by two radiologists with consensus reading. All MR examinations were prospectively performed within one month. Clinical and imaging characteristics of OGCTs were evaluated and compared with OSCs (control group). Results In 18 patients, 20 ovarian granulosa cell tumors were detected on MRI. Sixteen tumors appeared as solid or mostly solid mass (16/20), while 4 tumors as cystic mass. Pathological pelvic fluid was detected in 1 OGCT (1/18) and 11 OSCs (11/34) (p = 0.031).On T2 weighted imaging (T2WI), most of OGCTs displayed hyperintense signal and mixed signal (19/20); on T1 weighted imaging (T1WI), 11 OGCTs (11/20) displayed similar signal as on T2WI imaging. The lesion signal between OGCT and OSC differed significantly on both T1WI (p = 0.017) and T2WI (p = 0.002). Tumoral bleeding was detected in 6 OGCTs on MRI. On diffusion weighted imaging (DWI) images, OGCTs mostly appeared as high signal (16/20). Average apparent diffusion coefficient (ADC) value derived from DWI images in the OGCT group (0.84 ± 0.26× 10− 3 mm2/s was less than the control group (1.22 ± 0.47 × 10− 3 mm2/s) with statistical difference (p = 0.002). Conclusions MRI could provide important information in OGCT diagnosis. ADC value might be useful in differentiating OGCT from OSC.http://link.springer.com/article/10.1186/s13048-018-0416-xOvarian granulosa cell tumorSex-cord tumorMRIDiagnostic imaging |
| spellingShingle | He Zhang Hongyu Zhang Shouxin Gu Yanyu Zhang Xuefen Liu Guofu Zhang MR findings of primary ovarian granulosa cell tumor with focus on the differentiation with other ovarian sex cord-stromal tumors Journal of Ovarian Research Ovarian granulosa cell tumor Sex-cord tumor MRI Diagnostic imaging |
| title | MR findings of primary ovarian granulosa cell tumor with focus on the differentiation with other ovarian sex cord-stromal tumors |
| title_full | MR findings of primary ovarian granulosa cell tumor with focus on the differentiation with other ovarian sex cord-stromal tumors |
| title_fullStr | MR findings of primary ovarian granulosa cell tumor with focus on the differentiation with other ovarian sex cord-stromal tumors |
| title_full_unstemmed | MR findings of primary ovarian granulosa cell tumor with focus on the differentiation with other ovarian sex cord-stromal tumors |
| title_short | MR findings of primary ovarian granulosa cell tumor with focus on the differentiation with other ovarian sex cord-stromal tumors |
| title_sort | mr findings of primary ovarian granulosa cell tumor with focus on the differentiation with other ovarian sex cord stromal tumors |
| topic | Ovarian granulosa cell tumor Sex-cord tumor MRI Diagnostic imaging |
| url | http://link.springer.com/article/10.1186/s13048-018-0416-x |
| work_keys_str_mv | AT hezhang mrfindingsofprimaryovariangranulosacelltumorwithfocusonthedifferentiationwithotherovariansexcordstromaltumors AT hongyuzhang mrfindingsofprimaryovariangranulosacelltumorwithfocusonthedifferentiationwithotherovariansexcordstromaltumors AT shouxingu mrfindingsofprimaryovariangranulosacelltumorwithfocusonthedifferentiationwithotherovariansexcordstromaltumors AT yanyuzhang mrfindingsofprimaryovariangranulosacelltumorwithfocusonthedifferentiationwithotherovariansexcordstromaltumors AT xuefenliu mrfindingsofprimaryovariangranulosacelltumorwithfocusonthedifferentiationwithotherovariansexcordstromaltumors AT guofuzhang mrfindingsofprimaryovariangranulosacelltumorwithfocusonthedifferentiationwithotherovariansexcordstromaltumors |