Development of a MIP-Based QCM Sensor for Selective Detection of Penicillins in Aqueous Media
Pharmaceuticals wastes have been recognized as emerging pollutants to the environment. Among those, antibiotics in the aquatic environment are one of the major sources of concern, as chronic, low-dose exposure can lead to antibiotic resistance. Herein, we report on molecularly imprinted polymers (MI...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Chemosensors |
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| Online Access: | https://www.mdpi.com/2227-9040/9/12/362 |
| _version_ | 1827673424098492416 |
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| author | Shahin Haghdoust Usman Arshad Adnan Mujahid Leo Schranzhofer Peter Alexander Lieberzeit |
| author_facet | Shahin Haghdoust Usman Arshad Adnan Mujahid Leo Schranzhofer Peter Alexander Lieberzeit |
| author_sort | Shahin Haghdoust |
| collection | DOAJ |
| description | Pharmaceuticals wastes have been recognized as emerging pollutants to the environment. Among those, antibiotics in the aquatic environment are one of the major sources of concern, as chronic, low-dose exposure can lead to antibiotic resistance. Herein, we report on molecularly imprinted polymers (MIP) to recognize penicillin V potassium salt (PenV-K), penicillin G potassium salt (PenG-K), and amoxicillin sodium salt (Amo-Na), which belong to the most widespread group of antibiotics worldwide. Characterization and optimization led to two MIPs comprising methacrylic acid as the monomer and roughly 55% ethylene glycol dimethacrylate as the crosslinker. The obtained layers led to sensitive, selective, repeatable, and reusable sensor responses on quartz crystal microbalances (QCM). The LoD for PenV-K, PenG-K, and Amo-Na sensors are 0.25 mM, 0.30 mM, and 0.28 mM, respectively; imprinting factors reach at least around three. Furthermore, the sensors displayed relative selectivity factors of up to 50% among the three penicillins, which is appreciable given their structural similarity. |
| first_indexed | 2024-03-10T04:24:36Z |
| format | Article |
| id | doaj.art-309b19e93b3144be8e33bd44c9787285 |
| institution | Directory Open Access Journal |
| issn | 2227-9040 |
| language | English |
| last_indexed | 2024-03-10T04:24:36Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj.art-309b19e93b3144be8e33bd44c97872852023-11-23T07:41:38ZengMDPI AGChemosensors2227-90402021-12-0191236210.3390/chemosensors9120362Development of a MIP-Based QCM Sensor for Selective Detection of Penicillins in Aqueous MediaShahin Haghdoust0Usman Arshad1Adnan Mujahid2Leo Schranzhofer3Peter Alexander Lieberzeit4Department of Physical Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Strasse 42, 1090 Vienna, AustriaInstitute of Chemistry, University of the Punjab, Lahore 54590, PakistanInstitute of Chemistry, University of the Punjab, Lahore 54590, PakistanFunctional Surfaces and Nanostructures, Profactor GmbH, 4407 Steyr-Gleink, AustriaDepartment of Physical Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Strasse 42, 1090 Vienna, AustriaPharmaceuticals wastes have been recognized as emerging pollutants to the environment. Among those, antibiotics in the aquatic environment are one of the major sources of concern, as chronic, low-dose exposure can lead to antibiotic resistance. Herein, we report on molecularly imprinted polymers (MIP) to recognize penicillin V potassium salt (PenV-K), penicillin G potassium salt (PenG-K), and amoxicillin sodium salt (Amo-Na), which belong to the most widespread group of antibiotics worldwide. Characterization and optimization led to two MIPs comprising methacrylic acid as the monomer and roughly 55% ethylene glycol dimethacrylate as the crosslinker. The obtained layers led to sensitive, selective, repeatable, and reusable sensor responses on quartz crystal microbalances (QCM). The LoD for PenV-K, PenG-K, and Amo-Na sensors are 0.25 mM, 0.30 mM, and 0.28 mM, respectively; imprinting factors reach at least around three. Furthermore, the sensors displayed relative selectivity factors of up to 50% among the three penicillins, which is appreciable given their structural similarity.https://www.mdpi.com/2227-9040/9/12/362amoxicillin sodiumantibioticmolecularly imprinted polymerspenicillin V potassiumpenicillin G potassiumquartz crystal microbalance |
| spellingShingle | Shahin Haghdoust Usman Arshad Adnan Mujahid Leo Schranzhofer Peter Alexander Lieberzeit Development of a MIP-Based QCM Sensor for Selective Detection of Penicillins in Aqueous Media Chemosensors amoxicillin sodium antibiotic molecularly imprinted polymers penicillin V potassium penicillin G potassium quartz crystal microbalance |
| title | Development of a MIP-Based QCM Sensor for Selective Detection of Penicillins in Aqueous Media |
| title_full | Development of a MIP-Based QCM Sensor for Selective Detection of Penicillins in Aqueous Media |
| title_fullStr | Development of a MIP-Based QCM Sensor for Selective Detection of Penicillins in Aqueous Media |
| title_full_unstemmed | Development of a MIP-Based QCM Sensor for Selective Detection of Penicillins in Aqueous Media |
| title_short | Development of a MIP-Based QCM Sensor for Selective Detection of Penicillins in Aqueous Media |
| title_sort | development of a mip based qcm sensor for selective detection of penicillins in aqueous media |
| topic | amoxicillin sodium antibiotic molecularly imprinted polymers penicillin V potassium penicillin G potassium quartz crystal microbalance |
| url | https://www.mdpi.com/2227-9040/9/12/362 |
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