Association of Myocardial Energetic Efficiency with Circumferential and Longitudinal Left Ventricular Myocardial Function in Subjects with Increased Body Mass Index (the FATCOR Study)
Lower myocardial mechanic-energetic efficiency (MEEi), expressed as stroke volume/heart rate ratio (SV/HR) in mL/s/g of the left ventricular (LV) mass, is associated with the incidence of heart failure in subjects with cardiometabolic disorders. We explored the association of MEEi with LV systolic c...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/10/8/1581 |
| _version_ | 1797538314573578240 |
|---|---|
| author | Costantino Mancusi Helga Midtbø Nicola De Luca Hilde Halland Giovanni de Simone Eva Gerdts |
| author_facet | Costantino Mancusi Helga Midtbø Nicola De Luca Hilde Halland Giovanni de Simone Eva Gerdts |
| author_sort | Costantino Mancusi |
| collection | DOAJ |
| description | Lower myocardial mechanic-energetic efficiency (MEEi), expressed as stroke volume/heart rate ratio (SV/HR) in mL/s/g of the left ventricular (LV) mass, is associated with the incidence of heart failure in subjects with cardiometabolic disorders. We explored the association of MEEi with LV systolic circumferential and longitudinal myocardial function in 480 subjects with increased body mass index (BMI) without known cardiovascular disease (mean age 47 ± 9 years, 61% women, 63% obese, 74% with hypertension) participating in the fat-associated cardiovascular dysfunction (FATCOR) study. Insulin resistance was assessed by the homeostasis model assessment insulin-resistance index (HOMA-IR). SV was calculated by Doppler echocardiography. The LV systolic circumferential myocardial function was evaluated by midwall fractional shortening (MFS) and longitudinal function by global longitudinal strain (GLS). Patients were grouped into MEEi quartiles. The lowest MEEi quartile (<0.41 mL/s per g) was considered low MEEi. The association of MEEi with MFS and GLS were tested in multivariable linear regression analyses. Patients with low MEEi were more frequently men, with obesity and hypertension, dyslipidemia and higher HOMA-IR index (all <i>p</i> for trend <0.05). In multivariable analyses, lower MEEi was associated with lower LV myocardial function by MFS and GLS independent of higher LV mass and clinical variables, including older age, male sex, presence of hypertension and a higher triglycerides level (all <i>p</i> < 0.05). In conclusion, in subjects with increased BMI without known cardiovascular disease participating in the FATCOR study, reduced MEEi was associated with lower LV myocardial function both in the circumferential and longitudinal direction, independent of cardiometabolic factors. |
| first_indexed | 2024-03-10T12:28:47Z |
| format | Article |
| id | doaj.art-309dd89f93e74195ac2bf04cd8624c59 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T12:28:47Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-309dd89f93e74195ac2bf04cd8624c592023-11-21T14:46:31ZengMDPI AGJournal of Clinical Medicine2077-03832021-04-01108158110.3390/jcm10081581Association of Myocardial Energetic Efficiency with Circumferential and Longitudinal Left Ventricular Myocardial Function in Subjects with Increased Body Mass Index (the FATCOR Study)Costantino Mancusi0Helga Midtbø1Nicola De Luca2Hilde Halland3Giovanni de Simone4Eva Gerdts5Hypertension Research Center, Department of Advanced Biomedical Sciences, University Federico II of Naples, 80131 Naples, ItalyDepartment of Heart Disease, Haukeland University Hospital, 5021 Bergen, NorwayHypertension Research Center, Department of Advanced Biomedical Sciences, University Federico II of Naples, 80131 Naples, ItalyDepartment of Heart Disease, Haukeland University Hospital, 5021 Bergen, NorwayHypertension Research Center, Department of Advanced Biomedical Sciences, University Federico II of Naples, 80131 Naples, ItalyDepartment of Heart Disease, Haukeland University Hospital, 5021 Bergen, NorwayLower myocardial mechanic-energetic efficiency (MEEi), expressed as stroke volume/heart rate ratio (SV/HR) in mL/s/g of the left ventricular (LV) mass, is associated with the incidence of heart failure in subjects with cardiometabolic disorders. We explored the association of MEEi with LV systolic circumferential and longitudinal myocardial function in 480 subjects with increased body mass index (BMI) without known cardiovascular disease (mean age 47 ± 9 years, 61% women, 63% obese, 74% with hypertension) participating in the fat-associated cardiovascular dysfunction (FATCOR) study. Insulin resistance was assessed by the homeostasis model assessment insulin-resistance index (HOMA-IR). SV was calculated by Doppler echocardiography. The LV systolic circumferential myocardial function was evaluated by midwall fractional shortening (MFS) and longitudinal function by global longitudinal strain (GLS). Patients were grouped into MEEi quartiles. The lowest MEEi quartile (<0.41 mL/s per g) was considered low MEEi. The association of MEEi with MFS and GLS were tested in multivariable linear regression analyses. Patients with low MEEi were more frequently men, with obesity and hypertension, dyslipidemia and higher HOMA-IR index (all <i>p</i> for trend <0.05). In multivariable analyses, lower MEEi was associated with lower LV myocardial function by MFS and GLS independent of higher LV mass and clinical variables, including older age, male sex, presence of hypertension and a higher triglycerides level (all <i>p</i> < 0.05). In conclusion, in subjects with increased BMI without known cardiovascular disease participating in the FATCOR study, reduced MEEi was associated with lower LV myocardial function both in the circumferential and longitudinal direction, independent of cardiometabolic factors.https://www.mdpi.com/2077-0383/10/8/1581myocardial performancetriglyceridesglobal longitudinal strainleft ventricular mass |
| spellingShingle | Costantino Mancusi Helga Midtbø Nicola De Luca Hilde Halland Giovanni de Simone Eva Gerdts Association of Myocardial Energetic Efficiency with Circumferential and Longitudinal Left Ventricular Myocardial Function in Subjects with Increased Body Mass Index (the FATCOR Study) Journal of Clinical Medicine myocardial performance triglycerides global longitudinal strain left ventricular mass |
| title | Association of Myocardial Energetic Efficiency with Circumferential and Longitudinal Left Ventricular Myocardial Function in Subjects with Increased Body Mass Index (the FATCOR Study) |
| title_full | Association of Myocardial Energetic Efficiency with Circumferential and Longitudinal Left Ventricular Myocardial Function in Subjects with Increased Body Mass Index (the FATCOR Study) |
| title_fullStr | Association of Myocardial Energetic Efficiency with Circumferential and Longitudinal Left Ventricular Myocardial Function in Subjects with Increased Body Mass Index (the FATCOR Study) |
| title_full_unstemmed | Association of Myocardial Energetic Efficiency with Circumferential and Longitudinal Left Ventricular Myocardial Function in Subjects with Increased Body Mass Index (the FATCOR Study) |
| title_short | Association of Myocardial Energetic Efficiency with Circumferential and Longitudinal Left Ventricular Myocardial Function in Subjects with Increased Body Mass Index (the FATCOR Study) |
| title_sort | association of myocardial energetic efficiency with circumferential and longitudinal left ventricular myocardial function in subjects with increased body mass index the fatcor study |
| topic | myocardial performance triglycerides global longitudinal strain left ventricular mass |
| url | https://www.mdpi.com/2077-0383/10/8/1581 |
| work_keys_str_mv | AT costantinomancusi associationofmyocardialenergeticefficiencywithcircumferentialandlongitudinalleftventricularmyocardialfunctioninsubjectswithincreasedbodymassindexthefatcorstudy AT helgamidtbø associationofmyocardialenergeticefficiencywithcircumferentialandlongitudinalleftventricularmyocardialfunctioninsubjectswithincreasedbodymassindexthefatcorstudy AT nicoladeluca associationofmyocardialenergeticefficiencywithcircumferentialandlongitudinalleftventricularmyocardialfunctioninsubjectswithincreasedbodymassindexthefatcorstudy AT hildehalland associationofmyocardialenergeticefficiencywithcircumferentialandlongitudinalleftventricularmyocardialfunctioninsubjectswithincreasedbodymassindexthefatcorstudy AT giovannidesimone associationofmyocardialenergeticefficiencywithcircumferentialandlongitudinalleftventricularmyocardialfunctioninsubjectswithincreasedbodymassindexthefatcorstudy AT evagerdts associationofmyocardialenergeticefficiencywithcircumferentialandlongitudinalleftventricularmyocardialfunctioninsubjectswithincreasedbodymassindexthefatcorstudy |