Cardiorespiratory Fitness and Highly Sensitive Cardiac Troponin Levels in a Preventive Medicine Cohort
BackgroundCardiorespiratory fitness (CRF) and highly sensitive cardiac troponin T (hs‐cTnT) are associated with risk of all‐cause and cardiovascular mortality as well as incident heart failure. A link of low CRF to subclinical cardiac injury may explain this association. We hypothesized that CRF wou...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-12-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.116.003781 |
| _version_ | 1828876298772021248 |
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| author | Laura F. DeFina Benjamin L. Willis Nina B. Radford Robert H. Christenson Christopher R. deFilippi James A. de Lemos |
| author_facet | Laura F. DeFina Benjamin L. Willis Nina B. Radford Robert H. Christenson Christopher R. deFilippi James A. de Lemos |
| author_sort | Laura F. DeFina |
| collection | DOAJ |
| description | BackgroundCardiorespiratory fitness (CRF) and highly sensitive cardiac troponin T (hs‐cTnT) are associated with risk of all‐cause and cardiovascular mortality as well as incident heart failure. A link of low CRF to subclinical cardiac injury may explain this association. We hypothesized that CRF would be inversely associated with hs‐cTnT measured in healthy adults over age 50. Methods and ResultsWe evaluated 2498 participants (24.7% female, mean age 58.7 years) from the Cooper Center Longitudinal Study between August 2008 and January 2012. Plasma specimens obtained shortly before CRF estimates by Balke treadmill testing were used for hs‐cTnT assays. CRF was grouped into low CRF (category 1), moderate CRF (categories 2–3), and high CRF (categories 4–5). Multivariable logistic regression was used to estimate the association of CRF with hs‐cTnT. The prevalence of measurable hs‐cTnT (≥3 ng/L) was 78.5%. In multivariable analyses, low‐fit individuals were significantly more likely than high‐fit individuals to have elevated hs‐cTnT (≥14 ng/L) (odds ratio 2.47, 95% CI 1.10–5.36). ConclusionsIn healthy older adults, CRF is inversely associated with hs‐cTnT level adjusted for other risk factors. Prospective studies are needed to evaluate whether improving CRF is effective in preventing subclinical cardiac injury. |
| first_indexed | 2024-12-13T08:17:23Z |
| format | Article |
| id | doaj.art-309f75ef53dc428fa57df9cf60d1641f |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-13T08:17:23Z |
| publishDate | 2016-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-309f75ef53dc428fa57df9cf60d1641f2022-12-21T23:54:04ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802016-12-0151210.1161/JAHA.116.003781Cardiorespiratory Fitness and Highly Sensitive Cardiac Troponin Levels in a Preventive Medicine CohortLaura F. DeFina0Benjamin L. Willis1Nina B. Radford2Robert H. Christenson3Christopher R. deFilippi4James A. de Lemos5Cooper Institute, Dallas, TXCooper Institute, Dallas, TXCooper Clinic, Dallas, TXDepartment of Pathology, University of Maryland School of Medicine, Baltimore, MDDivision of Cardiovascular Medicine, University of Maryland School of Medicine, Baltimore, MDDivision of Cardiology, University of Texas Southwestern Medical Center, Dallas, TXBackgroundCardiorespiratory fitness (CRF) and highly sensitive cardiac troponin T (hs‐cTnT) are associated with risk of all‐cause and cardiovascular mortality as well as incident heart failure. A link of low CRF to subclinical cardiac injury may explain this association. We hypothesized that CRF would be inversely associated with hs‐cTnT measured in healthy adults over age 50. Methods and ResultsWe evaluated 2498 participants (24.7% female, mean age 58.7 years) from the Cooper Center Longitudinal Study between August 2008 and January 2012. Plasma specimens obtained shortly before CRF estimates by Balke treadmill testing were used for hs‐cTnT assays. CRF was grouped into low CRF (category 1), moderate CRF (categories 2–3), and high CRF (categories 4–5). Multivariable logistic regression was used to estimate the association of CRF with hs‐cTnT. The prevalence of measurable hs‐cTnT (≥3 ng/L) was 78.5%. In multivariable analyses, low‐fit individuals were significantly more likely than high‐fit individuals to have elevated hs‐cTnT (≥14 ng/L) (odds ratio 2.47, 95% CI 1.10–5.36). ConclusionsIn healthy older adults, CRF is inversely associated with hs‐cTnT level adjusted for other risk factors. Prospective studies are needed to evaluate whether improving CRF is effective in preventing subclinical cardiac injury.https://www.ahajournals.org/doi/10.1161/JAHA.116.003781cardiorespiratory fitnessexercise capacityhs‐cTnTtroponin |
| spellingShingle | Laura F. DeFina Benjamin L. Willis Nina B. Radford Robert H. Christenson Christopher R. deFilippi James A. de Lemos Cardiorespiratory Fitness and Highly Sensitive Cardiac Troponin Levels in a Preventive Medicine Cohort Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease cardiorespiratory fitness exercise capacity hs‐cTnT troponin |
| title | Cardiorespiratory Fitness and Highly Sensitive Cardiac Troponin Levels in a Preventive Medicine Cohort |
| title_full | Cardiorespiratory Fitness and Highly Sensitive Cardiac Troponin Levels in a Preventive Medicine Cohort |
| title_fullStr | Cardiorespiratory Fitness and Highly Sensitive Cardiac Troponin Levels in a Preventive Medicine Cohort |
| title_full_unstemmed | Cardiorespiratory Fitness and Highly Sensitive Cardiac Troponin Levels in a Preventive Medicine Cohort |
| title_short | Cardiorespiratory Fitness and Highly Sensitive Cardiac Troponin Levels in a Preventive Medicine Cohort |
| title_sort | cardiorespiratory fitness and highly sensitive cardiac troponin levels in a preventive medicine cohort |
| topic | cardiorespiratory fitness exercise capacity hs‐cTnT troponin |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.116.003781 |
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