CT-Screening for lung cancer does not increase the use of anxiolytic or antidepressant medication
<p>Abstract</p> <p>Background</p> <p>CT screening for lung cancer has recently been shown to reduce lung cancer mortality, but screening may have adverse mental health effects. We calculated risk ratios for prescription of anti-depressive (AD) or anxiolytic (AX) medicat...
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| Format: | Article |
| Language: | English |
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BMC
2012-05-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | http://www.biomedcentral.com/1471-2407/12/188 |
| _version_ | 1828809911011639296 |
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| author | Kaerlev Linda Iachina Maria Pedersen Jesper Green Anders Nørgård Bente |
| author_facet | Kaerlev Linda Iachina Maria Pedersen Jesper Green Anders Nørgård Bente |
| author_sort | Kaerlev Linda |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>CT screening for lung cancer has recently been shown to reduce lung cancer mortality, but screening may have adverse mental health effects. We calculated risk ratios for prescription of anti-depressive (AD) or anxiolytic (AX) medication redeemed at Danish pharmacies for participants in The Danish Lung Cancer Screening Trial (DLCST).</p> <p>Methods</p> <p>The DLCST was a randomized clinical trial which comprised 4,104 former or present smokers who were randomized from 12 May 2004 to 20 June 2006 to either CT scan of the chest, lung-function test and filling in questionnaires annually for five years in the period 1 April 2006–31 March 2010 (n = 2,052), or to a control group (n = 2,052) receiving similar procedures except CT scan. We used CT scan intervention group versus control group status as exposure. The follow-up period for use of AD or AX was three years. Baseline data on civil status, socioeconomic status, and co-morbidity as well as outcome data on AD and AX were obtained by linkage to national registries.</p> <p>Results</p> <p>The intervention and the control groups did not differ by age, gender, civil status, socio-economic position, co-morbidity index or former use of AD or AX. The adjusted risk ratio for at least one recipe of AD or AX in the CT intervention group during follow-up was not increased when adjusting for previous use of AD or AX, HR 1.00, 95 % CI (0.90-1.12). Similar results were seen when excluding subjects using AD or AX in a four-month or two-year period before baseline, when analyzing AD and AX separately, or requiring at least two recipes.</p> <p>Conclusions</p> <p>We found no indications that participation in a lung cancer CT-screening program increases the risk of specific adverse mental health outcomes.</p> <p>Trial registration</p> <p>Clinical Trials.gov Protocol Registration System (NCT00496977).</p> |
| first_indexed | 2024-12-12T09:03:32Z |
| format | Article |
| id | doaj.art-30a2b9c56e744e0194e598d0ac3905f1 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-12T09:03:32Z |
| publishDate | 2012-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-30a2b9c56e744e0194e598d0ac3905f12022-12-22T00:29:45ZengBMCBMC Cancer1471-24072012-05-0112118810.1186/1471-2407-12-188CT-Screening for lung cancer does not increase the use of anxiolytic or antidepressant medicationKaerlev LindaIachina MariaPedersen JesperGreen AndersNørgård Bente<p>Abstract</p> <p>Background</p> <p>CT screening for lung cancer has recently been shown to reduce lung cancer mortality, but screening may have adverse mental health effects. We calculated risk ratios for prescription of anti-depressive (AD) or anxiolytic (AX) medication redeemed at Danish pharmacies for participants in The Danish Lung Cancer Screening Trial (DLCST).</p> <p>Methods</p> <p>The DLCST was a randomized clinical trial which comprised 4,104 former or present smokers who were randomized from 12 May 2004 to 20 June 2006 to either CT scan of the chest, lung-function test and filling in questionnaires annually for five years in the period 1 April 2006–31 March 2010 (n = 2,052), or to a control group (n = 2,052) receiving similar procedures except CT scan. We used CT scan intervention group versus control group status as exposure. The follow-up period for use of AD or AX was three years. Baseline data on civil status, socioeconomic status, and co-morbidity as well as outcome data on AD and AX were obtained by linkage to national registries.</p> <p>Results</p> <p>The intervention and the control groups did not differ by age, gender, civil status, socio-economic position, co-morbidity index or former use of AD or AX. The adjusted risk ratio for at least one recipe of AD or AX in the CT intervention group during follow-up was not increased when adjusting for previous use of AD or AX, HR 1.00, 95 % CI (0.90-1.12). Similar results were seen when excluding subjects using AD or AX in a four-month or two-year period before baseline, when analyzing AD and AX separately, or requiring at least two recipes.</p> <p>Conclusions</p> <p>We found no indications that participation in a lung cancer CT-screening program increases the risk of specific adverse mental health outcomes.</p> <p>Trial registration</p> <p>Clinical Trials.gov Protocol Registration System (NCT00496977).</p>http://www.biomedcentral.com/1471-2407/12/188Lung cancerScreeningRandomised trialPsychosocial distress |
| spellingShingle | Kaerlev Linda Iachina Maria Pedersen Jesper Green Anders Nørgård Bente CT-Screening for lung cancer does not increase the use of anxiolytic or antidepressant medication BMC Cancer Lung cancer Screening Randomised trial Psychosocial distress |
| title | CT-Screening for lung cancer does not increase the use of anxiolytic or antidepressant medication |
| title_full | CT-Screening for lung cancer does not increase the use of anxiolytic or antidepressant medication |
| title_fullStr | CT-Screening for lung cancer does not increase the use of anxiolytic or antidepressant medication |
| title_full_unstemmed | CT-Screening for lung cancer does not increase the use of anxiolytic or antidepressant medication |
| title_short | CT-Screening for lung cancer does not increase the use of anxiolytic or antidepressant medication |
| title_sort | ct screening for lung cancer does not increase the use of anxiolytic or antidepressant medication |
| topic | Lung cancer Screening Randomised trial Psychosocial distress |
| url | http://www.biomedcentral.com/1471-2407/12/188 |
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