Methicillin-resistant Staphylococcus aureus in HIV patients: Risk factors associated with colonization and/or infection and methods for characterization of isolates - a systematic review
Staphylococcus aureus is an important cause of infections and HIV-infected individuals are frequently susceptible to this pathogen. The aim of this study was to perform a systematic review to identify both the risk factors associated with colonization/infection by methicillin-resistant S. aureus in...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier España
2014-11-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322014001100770&lng=en&tlng=en |
| _version_ | 1828298934754213888 |
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| author | Dennis de Carvalho Ferreira Glaucilene Rodrigues da Silva Fernanda Sampaio Cavalcante Flavia Lima do Carmo Leonardo Alexandre Fernandes Suelen Moreira Mauro Romero Leal Passos Ana Paula Vieira Colombo Katia Regina Netto dos Santos |
| author_facet | Dennis de Carvalho Ferreira Glaucilene Rodrigues da Silva Fernanda Sampaio Cavalcante Flavia Lima do Carmo Leonardo Alexandre Fernandes Suelen Moreira Mauro Romero Leal Passos Ana Paula Vieira Colombo Katia Regina Netto dos Santos |
| author_sort | Dennis de Carvalho Ferreira |
| collection | DOAJ |
| description | Staphylococcus aureus is an important cause of infections and HIV-infected individuals are frequently susceptible to this pathogen. The aim of this study was to perform a systematic review to identify both the risk factors associated with colonization/infection by methicillin-resistant S. aureus in HIV patients and the methods used for characterization of isolates. An electronic search of articles published between January 2001 and December 2013 was first conducted. Among 116 studies categorized as being at a quality level of A, B or C, only 9 studies were considered to have high methodological quality (level A). The majority of these studies were retrospective (4/9 studies). The risk factors associated with colonization/infection by S. aureus were use of antimicrobials (4/9 studies), previous hospitalization (4/9 studies) and low CD4+ T lymphocyte counts (<200 cells/μl) (3/9 studies). Culture in mannitol salt agar (3/9 studies) and the latex agglutination test (5/9 studies) were the main methods used for bacterial phenotypic identification. Genotypic profiles were accessed by pulsed-field gel electrophoresis (6/9 studies) and USA300 was the most prevalent lineage (5/9 studies). Most isolates were resistant to erythromycin (3/9 studies) and susceptible to vancomycin (4/9 studies). Ultimately, use of antimicrobials and previous hospitalization were the main risk factors for colonization/infection by methicillin-resistant S. aureus in HIV-infected individuals. However, the numbers of evaluated patients, the exclusion and inclusion criteria and the characterization of the S. aureus isolates were not uniform, which made it difficult to establish the characteristics associated with HIV patients who are colonized/infected by S. aureus. |
| first_indexed | 2024-04-13T12:48:16Z |
| format | Article |
| id | doaj.art-30a52537fc1b41a99a06e3186195e81a |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-04-13T12:48:16Z |
| publishDate | 2014-11-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-30a52537fc1b41a99a06e3186195e81a2022-12-22T02:46:19ZengElsevier EspañaClinics1980-53222014-11-01691177077610.6061/clinics/2014(11)11S1807-59322014001100770Methicillin-resistant Staphylococcus aureus in HIV patients: Risk factors associated with colonization and/or infection and methods for characterization of isolates - a systematic reviewDennis de Carvalho FerreiraGlaucilene Rodrigues da SilvaFernanda Sampaio CavalcanteFlavia Lima do CarmoLeonardo Alexandre FernandesSuelen MoreiraMauro Romero Leal PassosAna Paula Vieira ColomboKatia Regina Netto dos SantosStaphylococcus aureus is an important cause of infections and HIV-infected individuals are frequently susceptible to this pathogen. The aim of this study was to perform a systematic review to identify both the risk factors associated with colonization/infection by methicillin-resistant S. aureus in HIV patients and the methods used for characterization of isolates. An electronic search of articles published between January 2001 and December 2013 was first conducted. Among 116 studies categorized as being at a quality level of A, B or C, only 9 studies were considered to have high methodological quality (level A). The majority of these studies were retrospective (4/9 studies). The risk factors associated with colonization/infection by S. aureus were use of antimicrobials (4/9 studies), previous hospitalization (4/9 studies) and low CD4+ T lymphocyte counts (<200 cells/μl) (3/9 studies). Culture in mannitol salt agar (3/9 studies) and the latex agglutination test (5/9 studies) were the main methods used for bacterial phenotypic identification. Genotypic profiles were accessed by pulsed-field gel electrophoresis (6/9 studies) and USA300 was the most prevalent lineage (5/9 studies). Most isolates were resistant to erythromycin (3/9 studies) and susceptible to vancomycin (4/9 studies). Ultimately, use of antimicrobials and previous hospitalization were the main risk factors for colonization/infection by methicillin-resistant S. aureus in HIV-infected individuals. However, the numbers of evaluated patients, the exclusion and inclusion criteria and the characterization of the S. aureus isolates were not uniform, which made it difficult to establish the characteristics associated with HIV patients who are colonized/infected by S. aureus.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322014001100770&lng=en&tlng=enS. aureusHIVInfection and Colonization |
| spellingShingle | Dennis de Carvalho Ferreira Glaucilene Rodrigues da Silva Fernanda Sampaio Cavalcante Flavia Lima do Carmo Leonardo Alexandre Fernandes Suelen Moreira Mauro Romero Leal Passos Ana Paula Vieira Colombo Katia Regina Netto dos Santos Methicillin-resistant Staphylococcus aureus in HIV patients: Risk factors associated with colonization and/or infection and methods for characterization of isolates - a systematic review Clinics S. aureus HIV Infection and Colonization |
| title | Methicillin-resistant Staphylococcus aureus in HIV patients: Risk factors associated with colonization and/or infection and methods for characterization of isolates - a systematic review |
| title_full | Methicillin-resistant Staphylococcus aureus in HIV patients: Risk factors associated with colonization and/or infection and methods for characterization of isolates - a systematic review |
| title_fullStr | Methicillin-resistant Staphylococcus aureus in HIV patients: Risk factors associated with colonization and/or infection and methods for characterization of isolates - a systematic review |
| title_full_unstemmed | Methicillin-resistant Staphylococcus aureus in HIV patients: Risk factors associated with colonization and/or infection and methods for characterization of isolates - a systematic review |
| title_short | Methicillin-resistant Staphylococcus aureus in HIV patients: Risk factors associated with colonization and/or infection and methods for characterization of isolates - a systematic review |
| title_sort | methicillin resistant staphylococcus aureus in hiv patients risk factors associated with colonization and or infection and methods for characterization of isolates a systematic review |
| topic | S. aureus HIV Infection and Colonization |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322014001100770&lng=en&tlng=en |
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