Transporter-Targeted Nano-Sized Vehicles for Enhanced and Site-Specific Drug Delivery
Nano-devices are recognized as increasingly attractive to deliver therapeutics to target cells. The specificity of this approach can be improved by modifying the surface of the delivery vehicles such that they are recognized by the target cells. In the past, cell-surface receptors were exploited for...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-10-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/10/2837 |
| _version_ | 1797551988733378560 |
|---|---|
| author | Longfa Kou Qing Yao Hailin Zhang Maoping Chu Yangzom D. Bhutia Ruijie Chen Vadivel Ganapathy |
| author_facet | Longfa Kou Qing Yao Hailin Zhang Maoping Chu Yangzom D. Bhutia Ruijie Chen Vadivel Ganapathy |
| author_sort | Longfa Kou |
| collection | DOAJ |
| description | Nano-devices are recognized as increasingly attractive to deliver therapeutics to target cells. The specificity of this approach can be improved by modifying the surface of the delivery vehicles such that they are recognized by the target cells. In the past, cell-surface receptors were exploited for this purpose, but plasma membrane transporters also hold similar potential. Selective transporters are often highly expressed in biological barriers (e.g., intestinal barrier, blood–brain barrier, and blood–retinal barrier) in a site-specific manner, and play a key role in the vectorial transfer of nutrients. Similarly, selective transporters are also overexpressed in the plasma membrane of specific cell types under pathological states to meet the biological needs demanded by such conditions. Nano-drug delivery systems could be strategically modified to make them recognizable by these transporters to enhance the transfer of drugs across the biological barriers or to selectively expose specific cell types to therapeutic drugs. Here, we provide a comprehensive review and detailed evaluation of the recent advances in the field of transporter-targeted nano-drug delivery systems. We specifically focus on areas related to intestinal absorption, transfer across blood–brain barrier, tumor-cell selective targeting, ocular drug delivery, identification of the transporters appropriate for this purpose, and details of the rationale for the approach. |
| first_indexed | 2024-03-10T15:53:40Z |
| format | Article |
| id | doaj.art-30a57d78c9de410cbae92118c7c69db2 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T15:53:40Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-30a57d78c9de410cbae92118c7c69db22023-11-20T15:47:43ZengMDPI AGCancers2072-66942020-10-011210283710.3390/cancers12102837Transporter-Targeted Nano-Sized Vehicles for Enhanced and Site-Specific Drug DeliveryLongfa Kou0Qing Yao1Hailin Zhang2Maoping Chu3Yangzom D. Bhutia4Ruijie Chen5Vadivel Ganapathy6Department of Pharmacy, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Zhejiang 325027, ChinaWenzhou Municipal Key Laboratory of Pediatric Pharmacy, Zhejiang 325027, ChinaWenzhou Municipal Key Laboratory of Pediatric Pharmacy, Zhejiang 325027, ChinaWenzhou Municipal Key Laboratory of Pediatric Pharmacy, Zhejiang 325027, ChinaDepartment of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USADepartment of Pharmacy, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Zhejiang 325027, ChinaDepartment of Pharmacy, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Zhejiang 325027, ChinaNano-devices are recognized as increasingly attractive to deliver therapeutics to target cells. The specificity of this approach can be improved by modifying the surface of the delivery vehicles such that they are recognized by the target cells. In the past, cell-surface receptors were exploited for this purpose, but plasma membrane transporters also hold similar potential. Selective transporters are often highly expressed in biological barriers (e.g., intestinal barrier, blood–brain barrier, and blood–retinal barrier) in a site-specific manner, and play a key role in the vectorial transfer of nutrients. Similarly, selective transporters are also overexpressed in the plasma membrane of specific cell types under pathological states to meet the biological needs demanded by such conditions. Nano-drug delivery systems could be strategically modified to make them recognizable by these transporters to enhance the transfer of drugs across the biological barriers or to selectively expose specific cell types to therapeutic drugs. Here, we provide a comprehensive review and detailed evaluation of the recent advances in the field of transporter-targeted nano-drug delivery systems. We specifically focus on areas related to intestinal absorption, transfer across blood–brain barrier, tumor-cell selective targeting, ocular drug delivery, identification of the transporters appropriate for this purpose, and details of the rationale for the approach.https://www.mdpi.com/2072-6694/12/10/2837plasma membrane transportersnano-drug delivery systemstargeted drug deliveryoral absorptionsite-specific drug delivery |
| spellingShingle | Longfa Kou Qing Yao Hailin Zhang Maoping Chu Yangzom D. Bhutia Ruijie Chen Vadivel Ganapathy Transporter-Targeted Nano-Sized Vehicles for Enhanced and Site-Specific Drug Delivery Cancers plasma membrane transporters nano-drug delivery systems targeted drug delivery oral absorption site-specific drug delivery |
| title | Transporter-Targeted Nano-Sized Vehicles for Enhanced and Site-Specific Drug Delivery |
| title_full | Transporter-Targeted Nano-Sized Vehicles for Enhanced and Site-Specific Drug Delivery |
| title_fullStr | Transporter-Targeted Nano-Sized Vehicles for Enhanced and Site-Specific Drug Delivery |
| title_full_unstemmed | Transporter-Targeted Nano-Sized Vehicles for Enhanced and Site-Specific Drug Delivery |
| title_short | Transporter-Targeted Nano-Sized Vehicles for Enhanced and Site-Specific Drug Delivery |
| title_sort | transporter targeted nano sized vehicles for enhanced and site specific drug delivery |
| topic | plasma membrane transporters nano-drug delivery systems targeted drug delivery oral absorption site-specific drug delivery |
| url | https://www.mdpi.com/2072-6694/12/10/2837 |
| work_keys_str_mv | AT longfakou transportertargetednanosizedvehiclesforenhancedandsitespecificdrugdelivery AT qingyao transportertargetednanosizedvehiclesforenhancedandsitespecificdrugdelivery AT hailinzhang transportertargetednanosizedvehiclesforenhancedandsitespecificdrugdelivery AT maopingchu transportertargetednanosizedvehiclesforenhancedandsitespecificdrugdelivery AT yangzomdbhutia transportertargetednanosizedvehiclesforenhancedandsitespecificdrugdelivery AT ruijiechen transportertargetednanosizedvehiclesforenhancedandsitespecificdrugdelivery AT vadivelganapathy transportertargetednanosizedvehiclesforenhancedandsitespecificdrugdelivery |