Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in Argentina
Background: Quadrivalent cell-based influenza vaccines (QIVc) avoid egg-adaptive mutations and can be more effective than traditional quadrivalent egg-based influenza vaccines (QIVe). This analysis compared the cost-effectiveness of QIVc and QIVe in Argentinian populations < 65 years old from the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/10/1627 |
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| author | Analía Urueña Paula Micone María Cecilia Magneres Ian McGovern Joaquin Mould-Quevedo Túlio Tadeu Rocha Sarmento Norberto Giglio |
| author_facet | Analía Urueña Paula Micone María Cecilia Magneres Ian McGovern Joaquin Mould-Quevedo Túlio Tadeu Rocha Sarmento Norberto Giglio |
| author_sort | Analía Urueña |
| collection | DOAJ |
| description | Background: Quadrivalent cell-based influenza vaccines (QIVc) avoid egg-adaptive mutations and can be more effective than traditional quadrivalent egg-based influenza vaccines (QIVe). This analysis compared the cost-effectiveness of QIVc and QIVe in Argentinian populations < 65 years old from the payer and societal perspectives. Methods: A static decision tree model compared the costs and health benefits of vaccination with QIVc vs. QIVe using a one-year time horizon. The relative vaccine effectiveness of QIVc vs. QIVe was assumed to be 8.1% for children and 11.4% for adults. An alternative high egg-adaptation scenario was also assessed. Model inputs were sourced from Argentina or the international literature. Deterministic and probabilistic sensitivity analyses were performed. Results: Compared to QIVe, QIVc would prevent 17,857 general practitioner visits, 2418 complications, 816 hospitalizations, and 12 deaths per year. From the payers’ perspective, the incremental cost-effectiveness ratio per quality-adjusted life years gained was USD12,214 in the base case and USD2311 in the high egg-adaptation scenario. QIVc was cost-saving from the societal perspective in both scenarios. Conclusions: QIVc in Argentina would be cost-effective relative to QIVe. The potential health benefits and savings would be even higher in high egg-adaptation seasons. |
| first_indexed | 2024-03-09T19:24:41Z |
| format | Article |
| id | doaj.art-30a62102180f4464b0fe1681a4d403ab |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T19:24:41Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-30a62102180f4464b0fe1681a4d403ab2023-11-24T03:03:14ZengMDPI AGVaccines2076-393X2022-09-011010162710.3390/vaccines10101627Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in ArgentinaAnalía Urueña0Paula Micone1María Cecilia Magneres2Ian McGovern3Joaquin Mould-Quevedo4Túlio Tadeu Rocha Sarmento5Norberto Giglio6Centre for the Study of Prevention and Control of Transmissible Diseases(CEPyCET), ISalud University, Buenos Aires C1095AAS, ArgentinaGynecology Department, Hospital Carlos G Durand, Buenos Aires C1095AAS, ArgentinaSeqirus S.A, Medical Affairs, Buenos Aires C1095AAS, ArgentinaSeqirus USA Inc., Medical Affairs, Summit, NJ 07901, USASeqirus USA Inc., Medical Affairs, Summit, NJ 07901, USACerner Enviza, São Paulo 04794, BrazilEpidemiology Department, Hospital de Niños Ricardo Gutiérrez, Buenos Aires C1095AAS, ArgentinaBackground: Quadrivalent cell-based influenza vaccines (QIVc) avoid egg-adaptive mutations and can be more effective than traditional quadrivalent egg-based influenza vaccines (QIVe). This analysis compared the cost-effectiveness of QIVc and QIVe in Argentinian populations < 65 years old from the payer and societal perspectives. Methods: A static decision tree model compared the costs and health benefits of vaccination with QIVc vs. QIVe using a one-year time horizon. The relative vaccine effectiveness of QIVc vs. QIVe was assumed to be 8.1% for children and 11.4% for adults. An alternative high egg-adaptation scenario was also assessed. Model inputs were sourced from Argentina or the international literature. Deterministic and probabilistic sensitivity analyses were performed. Results: Compared to QIVe, QIVc would prevent 17,857 general practitioner visits, 2418 complications, 816 hospitalizations, and 12 deaths per year. From the payers’ perspective, the incremental cost-effectiveness ratio per quality-adjusted life years gained was USD12,214 in the base case and USD2311 in the high egg-adaptation scenario. QIVc was cost-saving from the societal perspective in both scenarios. Conclusions: QIVc in Argentina would be cost-effective relative to QIVe. The potential health benefits and savings would be even higher in high egg-adaptation seasons.https://www.mdpi.com/2076-393X/10/10/1627influenza vaccinationcell-based vaccinecost-effectivenessArgentinaegg adaptation |
| spellingShingle | Analía Urueña Paula Micone María Cecilia Magneres Ian McGovern Joaquin Mould-Quevedo Túlio Tadeu Rocha Sarmento Norberto Giglio Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in Argentina Vaccines influenza vaccination cell-based vaccine cost-effectiveness Argentina egg adaptation |
| title | Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in Argentina |
| title_full | Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in Argentina |
| title_fullStr | Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in Argentina |
| title_full_unstemmed | Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in Argentina |
| title_short | Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in Argentina |
| title_sort | cost effectiveness analysis of cell versus egg based seasonal influenza vaccination in children and adults in argentina |
| topic | influenza vaccination cell-based vaccine cost-effectiveness Argentina egg adaptation |
| url | https://www.mdpi.com/2076-393X/10/10/1627 |
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