Evaluation of the Relationship between T2*CMR and Cardiac Depolarization and Repolarization Parameters in Beta-Thalassemia Patients
Background: Cardiac iron overload causes severe cardiac complications and is a leading cause of death in beta-thalassemia major patient. T2*CMR can detect preclinical cardiac iron overload. We evaluated the ability of 12-lead electrocardiographic atrial and ventricular depolarization and repolarizat...
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| Format: | Article |
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Kerman University of Medical Sciences
2024-03-01
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| Series: | Journal of Kerman University of Medical Sciences |
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| Online Access: | https://jkmu.kmu.ac.ir/article_92261_e3fa1efb3bc7c7e9792d57e2a04e8180.pdf |
| _version_ | 1797247929479593984 |
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| author | yazdan ghandi Bita Ghahremani Aziz Eghbali Parsa Yousefichaijan Masoud Bahrami |
| author_facet | yazdan ghandi Bita Ghahremani Aziz Eghbali Parsa Yousefichaijan Masoud Bahrami |
| author_sort | yazdan ghandi |
| collection | DOAJ |
| description | Background: Cardiac iron overload causes severe cardiac complications and is a leading cause of death in beta-thalassemia major patient. T2*CMR can detect preclinical cardiac iron overload. We evaluated the ability of 12-lead electrocardiographic atrial and ventricular depolarization and repolarization parameters to predict cardiac iron loading in TM.Materials and methods: This cross-sectional study was conducted on Patients with Beta thalassemia major; all participants underwent standard 12 lead electrocardiogram during a single study visit and the depolarization and repolarization parameters of ECG were measured and compared to the cardiac iron level detected by T2*CMR, with a detectable cardiac iron cutoff of T2*less than 20 ms.Results: A total of 26 patients (mean 26.19 years old, 34.62% male) were included. Mean T2*CMR values were 21.53 ms (46.15% <20 ms, 53.85% ≥20 ms). Among ECG parameters, only Pwd, QTc and QTcd (p: 0.026, 0.030, and 0.006 respectively) were significantly prolonged in patients with T2* < 20 ms compared to patients with T2*≥ 20 ms. There was a statistically negative Correlation between T2 * CMR and Pwd and QTcd (p: 0.028, and 0.021 respectively). Moreover, no correlation was found between Tp-e, Tp-e d, JTc, JTcd, Tp-e/QT, Tp-e/JT, Tp-e/JTc and T2* values.Conclusions: PWD and QTcd can be used as an alternative to T2*CMR to predict cardiac iron load levels in patients with beta thalassemia major. |
| first_indexed | 2024-04-24T20:06:30Z |
| format | Article |
| id | doaj.art-30a9221ce6a24709b7f9c1318ab13996 |
| institution | Directory Open Access Journal |
| issn | 1023-9510 2008-2843 |
| language | English |
| last_indexed | 2024-04-24T20:06:30Z |
| publishDate | 2024-03-01 |
| publisher | Kerman University of Medical Sciences |
| record_format | Article |
| series | Journal of Kerman University of Medical Sciences |
| spelling | doaj.art-30a9221ce6a24709b7f9c1318ab139962024-03-24T05:09:53ZengKerman University of Medical SciencesJournal of Kerman University of Medical Sciences1023-95102008-28432024-03-01311465010.34172/jkmu.2024.0892261Evaluation of the Relationship between T2*CMR and Cardiac Depolarization and Repolarization Parameters in Beta-Thalassemia Patientsyazdan ghandi0Bita Ghahremani1Aziz Eghbali2Parsa Yousefichaijan3Masoud Bahrami4Amirkabir Hospital, School of Medicine, Department of Pediatrics, Pediatric Cardiology, Arak University of Medical Sciences, Arak, IranStudent Research Committee, Arak University of Medical Sciences, Arak, Iran.Pediatric Oncology, Iran University of Medical Sciences, Tehran, IranAmir Kabir Hospital, Department of Pediatric Nephrology, Associate Professor of Pediatric Nephrology, Arak University of Medical Sciences, Arak, Iran.Arak University of Medical SciencesBackground: Cardiac iron overload causes severe cardiac complications and is a leading cause of death in beta-thalassemia major patient. T2*CMR can detect preclinical cardiac iron overload. We evaluated the ability of 12-lead electrocardiographic atrial and ventricular depolarization and repolarization parameters to predict cardiac iron loading in TM.Materials and methods: This cross-sectional study was conducted on Patients with Beta thalassemia major; all participants underwent standard 12 lead electrocardiogram during a single study visit and the depolarization and repolarization parameters of ECG were measured and compared to the cardiac iron level detected by T2*CMR, with a detectable cardiac iron cutoff of T2*less than 20 ms.Results: A total of 26 patients (mean 26.19 years old, 34.62% male) were included. Mean T2*CMR values were 21.53 ms (46.15% <20 ms, 53.85% ≥20 ms). Among ECG parameters, only Pwd, QTc and QTcd (p: 0.026, 0.030, and 0.006 respectively) were significantly prolonged in patients with T2* < 20 ms compared to patients with T2*≥ 20 ms. There was a statistically negative Correlation between T2 * CMR and Pwd and QTcd (p: 0.028, and 0.021 respectively). Moreover, no correlation was found between Tp-e, Tp-e d, JTc, JTcd, Tp-e/QT, Tp-e/JT, Tp-e/JTc and T2* values.Conclusions: PWD and QTcd can be used as an alternative to T2*CMR to predict cardiac iron load levels in patients with beta thalassemia major.https://jkmu.kmu.ac.ir/article_92261_e3fa1efb3bc7c7e9792d57e2a04e8180.pdfbeta-thalassemia majordepolarizationecgrepolarizationt2*cmr |
| spellingShingle | yazdan ghandi Bita Ghahremani Aziz Eghbali Parsa Yousefichaijan Masoud Bahrami Evaluation of the Relationship between T2*CMR and Cardiac Depolarization and Repolarization Parameters in Beta-Thalassemia Patients Journal of Kerman University of Medical Sciences beta-thalassemia major depolarization ecg repolarization t2*cmr |
| title | Evaluation of the Relationship between T2*CMR and Cardiac Depolarization and Repolarization Parameters in Beta-Thalassemia Patients |
| title_full | Evaluation of the Relationship between T2*CMR and Cardiac Depolarization and Repolarization Parameters in Beta-Thalassemia Patients |
| title_fullStr | Evaluation of the Relationship between T2*CMR and Cardiac Depolarization and Repolarization Parameters in Beta-Thalassemia Patients |
| title_full_unstemmed | Evaluation of the Relationship between T2*CMR and Cardiac Depolarization and Repolarization Parameters in Beta-Thalassemia Patients |
| title_short | Evaluation of the Relationship between T2*CMR and Cardiac Depolarization and Repolarization Parameters in Beta-Thalassemia Patients |
| title_sort | evaluation of the relationship between t2 cmr and cardiac depolarization and repolarization parameters in beta thalassemia patients |
| topic | beta-thalassemia major depolarization ecg repolarization t2*cmr |
| url | https://jkmu.kmu.ac.ir/article_92261_e3fa1efb3bc7c7e9792d57e2a04e8180.pdf |
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