The Effect of Dalbavancin in Moderate to Severe Hidradenitis Suppurativa
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by painful nodules, abscesses, and fistulas, localized to the areas of the folds where apocrine glands are present: the armpits, groin, inframammary region, and genital or perineal region. The management is still chal...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/11/1573 |
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| author | Elisa Molinelli Claudia Sapigni Giovanni Marco D’Agostino Valerio Brisigotti Giulio Rizzetto Ivan Bobyr Oscar Cirioni Andrea Giacometti Lucia Brescini Sara Mazzanti Annamaria Offidani Oriana Simonetti |
| author_facet | Elisa Molinelli Claudia Sapigni Giovanni Marco D’Agostino Valerio Brisigotti Giulio Rizzetto Ivan Bobyr Oscar Cirioni Andrea Giacometti Lucia Brescini Sara Mazzanti Annamaria Offidani Oriana Simonetti |
| author_sort | Elisa Molinelli |
| collection | DOAJ |
| description | Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by painful nodules, abscesses, and fistulas, localized to the areas of the folds where apocrine glands are present: the armpits, groin, inframammary region, and genital or perineal region. The management is still challenging, and it includes mainly systemic antibiotics, immunosuppressors, and biologic agents. Antibiotics are frequently used in the management of HS for their anti-inflammatory, immunomodulatory, and antimicrobial properties, but no data have been reported regarding the use of dalbavancin in HS. The aim of our practice was to evaluate efficacy, flare, and disease-free survival after dalbavancin therapy in a selected population with HS. We report the experience of the Ancona Dermatology Clinic in treating HS flare-ups with dalbavancin and its rationale for use. Our observation shows that the use of dalbavancin is an effective and well-tolerated treatment for the management of Hurley stage II-III HS; currently, dalbavancin should be considered as a supportive therapy for selected patients. |
| first_indexed | 2024-03-09T19:18:53Z |
| format | Article |
| id | doaj.art-30aa6490c0224761ac808a7b549dce70 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T19:18:53Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-30aa6490c0224761ac808a7b549dce702023-11-24T03:28:35ZengMDPI AGAntibiotics2079-63822022-11-011111157310.3390/antibiotics11111573The Effect of Dalbavancin in Moderate to Severe Hidradenitis SuppurativaElisa Molinelli0Claudia Sapigni1Giovanni Marco D’Agostino2Valerio Brisigotti3Giulio Rizzetto4Ivan Bobyr5Oscar Cirioni6Andrea Giacometti7Lucia Brescini8Sara Mazzanti9Annamaria Offidani10Oriana Simonetti11Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60121 Ancona, ItalyDermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60121 Ancona, ItalyDermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60121 Ancona, ItalyDermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60121 Ancona, ItalyDermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60121 Ancona, ItalyDermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60121 Ancona, ItalyDermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60121 Ancona, ItalyClinic of Infectious Diseases, Department of Biochemical Sciences and Public Health, Polytechnic University of the Marche Region, 60121 Ancona, ItalyClinic of Infectious Diseases, Department of Biochemical Sciences and Public Health, Polytechnic University of the Marche Region, 60121 Ancona, ItalyClinic of Infectious Diseases, Department of Biochemical Sciences and Public Health, Polytechnic University of the Marche Region, 60121 Ancona, ItalyDermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60121 Ancona, ItalyDermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60121 Ancona, ItalyHidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by painful nodules, abscesses, and fistulas, localized to the areas of the folds where apocrine glands are present: the armpits, groin, inframammary region, and genital or perineal region. The management is still challenging, and it includes mainly systemic antibiotics, immunosuppressors, and biologic agents. Antibiotics are frequently used in the management of HS for their anti-inflammatory, immunomodulatory, and antimicrobial properties, but no data have been reported regarding the use of dalbavancin in HS. The aim of our practice was to evaluate efficacy, flare, and disease-free survival after dalbavancin therapy in a selected population with HS. We report the experience of the Ancona Dermatology Clinic in treating HS flare-ups with dalbavancin and its rationale for use. Our observation shows that the use of dalbavancin is an effective and well-tolerated treatment for the management of Hurley stage II-III HS; currently, dalbavancin should be considered as a supportive therapy for selected patients.https://www.mdpi.com/2079-6382/11/11/1573hidradenitis suppurativadalbavancinantibioticstreatmentbiologic agents |
| spellingShingle | Elisa Molinelli Claudia Sapigni Giovanni Marco D’Agostino Valerio Brisigotti Giulio Rizzetto Ivan Bobyr Oscar Cirioni Andrea Giacometti Lucia Brescini Sara Mazzanti Annamaria Offidani Oriana Simonetti The Effect of Dalbavancin in Moderate to Severe Hidradenitis Suppurativa Antibiotics hidradenitis suppurativa dalbavancin antibiotics treatment biologic agents |
| title | The Effect of Dalbavancin in Moderate to Severe Hidradenitis Suppurativa |
| title_full | The Effect of Dalbavancin in Moderate to Severe Hidradenitis Suppurativa |
| title_fullStr | The Effect of Dalbavancin in Moderate to Severe Hidradenitis Suppurativa |
| title_full_unstemmed | The Effect of Dalbavancin in Moderate to Severe Hidradenitis Suppurativa |
| title_short | The Effect of Dalbavancin in Moderate to Severe Hidradenitis Suppurativa |
| title_sort | effect of dalbavancin in moderate to severe hidradenitis suppurativa |
| topic | hidradenitis suppurativa dalbavancin antibiotics treatment biologic agents |
| url | https://www.mdpi.com/2079-6382/11/11/1573 |
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