The Role of Nitric Oxide in Stem Cell Biology
Nitric oxide (NO) is a gaseous biomolecule endogenously synthesized with an essential role in embryonic development and several physiological functions, such as regulating mitochondrial respiration and modulation of the immune response. The dual role of NO in embryonic stem cells (ESCs) has been pre...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/3/497 |
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| author | Estefanía Caballano-Infantes Gladys Margot Cahuana Francisco Javier Bedoya Carmen Salguero-Aranda Juan R. Tejedo |
| author_facet | Estefanía Caballano-Infantes Gladys Margot Cahuana Francisco Javier Bedoya Carmen Salguero-Aranda Juan R. Tejedo |
| author_sort | Estefanía Caballano-Infantes |
| collection | DOAJ |
| description | Nitric oxide (NO) is a gaseous biomolecule endogenously synthesized with an essential role in embryonic development and several physiological functions, such as regulating mitochondrial respiration and modulation of the immune response. The dual role of NO in embryonic stem cells (ESCs) has been previously reported, preserving pluripotency and cell survival or inducing differentiation with a dose-dependent pattern. In this line, high doses of NO have been used in vitro cultures to induce focused differentiation toward different cell lineages being a key molecule in the regenerative medicine field. Moreover, optimal conditions to promote pluripotency in vitro are essential for their use in advanced therapies. In this sense, the molecular mechanisms underlying stemness regulation by NO have been studied intensively over the current years. Recently, we have reported the role of low NO as a hypoxia-like inducer in pluripotent stem cells (PSCs), which supports using this molecule to maintain pluripotency under normoxic conditions. In this review, we stress the role of NO levels on stem cells (SCs) fate as a new approach for potential cell therapy strategies. Furthermore, we highlight the recent uses of NO in regenerative medicine due to their properties regulating SCs biology. |
| first_indexed | 2024-03-09T20:11:26Z |
| format | Article |
| id | doaj.art-30acd65e860643d683e9c48c5ebdfdb4 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T20:11:26Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-30acd65e860643d683e9c48c5ebdfdb42023-11-24T00:13:11ZengMDPI AGAntioxidants2076-39212022-03-0111349710.3390/antiox11030497The Role of Nitric Oxide in Stem Cell BiologyEstefanía Caballano-Infantes0Gladys Margot Cahuana1Francisco Javier Bedoya2Carmen Salguero-Aranda3Juan R. Tejedo4Department of Molecular Biology and Biochemical Engineering, Universidad Pablo de Olavide, 41013 Seville, SpainDepartment of Molecular Biology and Biochemical Engineering, Universidad Pablo de Olavide, 41013 Seville, SpainDepartment of Molecular Biology and Biochemical Engineering, Universidad Pablo de Olavide, 41013 Seville, SpainDepartment of Pathology, Institute of Biomedicine of Seville (IBiS), Virgen del Rocio University Hospital, CSIC-University of Seville, 41013 Seville, SpainDepartment of Molecular Biology and Biochemical Engineering, Universidad Pablo de Olavide, 41013 Seville, SpainNitric oxide (NO) is a gaseous biomolecule endogenously synthesized with an essential role in embryonic development and several physiological functions, such as regulating mitochondrial respiration and modulation of the immune response. The dual role of NO in embryonic stem cells (ESCs) has been previously reported, preserving pluripotency and cell survival or inducing differentiation with a dose-dependent pattern. In this line, high doses of NO have been used in vitro cultures to induce focused differentiation toward different cell lineages being a key molecule in the regenerative medicine field. Moreover, optimal conditions to promote pluripotency in vitro are essential for their use in advanced therapies. In this sense, the molecular mechanisms underlying stemness regulation by NO have been studied intensively over the current years. Recently, we have reported the role of low NO as a hypoxia-like inducer in pluripotent stem cells (PSCs), which supports using this molecule to maintain pluripotency under normoxic conditions. In this review, we stress the role of NO levels on stem cells (SCs) fate as a new approach for potential cell therapy strategies. Furthermore, we highlight the recent uses of NO in regenerative medicine due to their properties regulating SCs biology.https://www.mdpi.com/2076-3921/11/3/497nitric oxidestem cellevolutioncell signalingcell differentiationpluripotency |
| spellingShingle | Estefanía Caballano-Infantes Gladys Margot Cahuana Francisco Javier Bedoya Carmen Salguero-Aranda Juan R. Tejedo The Role of Nitric Oxide in Stem Cell Biology Antioxidants nitric oxide stem cell evolution cell signaling cell differentiation pluripotency |
| title | The Role of Nitric Oxide in Stem Cell Biology |
| title_full | The Role of Nitric Oxide in Stem Cell Biology |
| title_fullStr | The Role of Nitric Oxide in Stem Cell Biology |
| title_full_unstemmed | The Role of Nitric Oxide in Stem Cell Biology |
| title_short | The Role of Nitric Oxide in Stem Cell Biology |
| title_sort | role of nitric oxide in stem cell biology |
| topic | nitric oxide stem cell evolution cell signaling cell differentiation pluripotency |
| url | https://www.mdpi.com/2076-3921/11/3/497 |
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