Chitosan Lactate Particles for Non-Compression Hemostasis on Hepatic Resection
The liver is the most complex vascular anatomy of all human organs, with extremely rich blood flow and fragile texture. Massive liver bleeding usually occurs after traumatic liver injury, causing severe systematic issues. Thus, bleeding control is critical in hindering mortality rates and complicati...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/15/3/656 |
| _version_ | 1797623382919872512 |
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| author | Yuhui Jiang Xiaoxuan Tang Tao Li Jue Ling Yifan Ge Yumin Yang |
| author_facet | Yuhui Jiang Xiaoxuan Tang Tao Li Jue Ling Yifan Ge Yumin Yang |
| author_sort | Yuhui Jiang |
| collection | DOAJ |
| description | The liver is the most complex vascular anatomy of all human organs, with extremely rich blood flow and fragile texture. Massive liver bleeding usually occurs after traumatic liver injury, causing severe systematic issues. Thus, bleeding control is critical in hindering mortality rates and complications in patients. In this study, non-compression hemostasis materials based on chitosan lactate particles (CLP) were developed for handling liver bleeding after injuries. CLP showed good blood biocompatibility and antibacterial performance against <i>S. aureus</i>. Taking advantage of the vital capacity of CLP to promote red blood cell and platelet adhesion, CLP exhibited in vivo homeostasis properties as non-compression hemostasis materials for traumatic liver injury, both in SD rats, New Zealand rabbits, or in beagles. Whereas CLP has better hemostasis than the commercial hemostatic agent Celox™. |
| first_indexed | 2024-03-11T09:28:08Z |
| format | Article |
| id | doaj.art-30aeb9062ce44c21945969de6a074e45 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-11T09:28:08Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-30aeb9062ce44c21945969de6a074e452023-11-16T17:48:41ZengMDPI AGPolymers2073-43602023-01-0115365610.3390/polym15030656Chitosan Lactate Particles for Non-Compression Hemostasis on Hepatic ResectionYuhui Jiang0Xiaoxuan Tang1Tao Li2Jue Ling3Yifan Ge4Yumin Yang5Medical School of Nantong University, Nantong 226001, ChinaMedical School of Nantong University, Nantong 226001, ChinaKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, ChinaKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, ChinaKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, ChinaMedical School of Nantong University, Nantong 226001, ChinaThe liver is the most complex vascular anatomy of all human organs, with extremely rich blood flow and fragile texture. Massive liver bleeding usually occurs after traumatic liver injury, causing severe systematic issues. Thus, bleeding control is critical in hindering mortality rates and complications in patients. In this study, non-compression hemostasis materials based on chitosan lactate particles (CLP) were developed for handling liver bleeding after injuries. CLP showed good blood biocompatibility and antibacterial performance against <i>S. aureus</i>. Taking advantage of the vital capacity of CLP to promote red blood cell and platelet adhesion, CLP exhibited in vivo homeostasis properties as non-compression hemostasis materials for traumatic liver injury, both in SD rats, New Zealand rabbits, or in beagles. Whereas CLP has better hemostasis than the commercial hemostatic agent Celox™.https://www.mdpi.com/2073-4360/15/3/656chitosannon-compression hemostasisbiocompatibilityantibacterialpolysaccharides |
| spellingShingle | Yuhui Jiang Xiaoxuan Tang Tao Li Jue Ling Yifan Ge Yumin Yang Chitosan Lactate Particles for Non-Compression Hemostasis on Hepatic Resection Polymers chitosan non-compression hemostasis biocompatibility antibacterial polysaccharides |
| title | Chitosan Lactate Particles for Non-Compression Hemostasis on Hepatic Resection |
| title_full | Chitosan Lactate Particles for Non-Compression Hemostasis on Hepatic Resection |
| title_fullStr | Chitosan Lactate Particles for Non-Compression Hemostasis on Hepatic Resection |
| title_full_unstemmed | Chitosan Lactate Particles for Non-Compression Hemostasis on Hepatic Resection |
| title_short | Chitosan Lactate Particles for Non-Compression Hemostasis on Hepatic Resection |
| title_sort | chitosan lactate particles for non compression hemostasis on hepatic resection |
| topic | chitosan non-compression hemostasis biocompatibility antibacterial polysaccharides |
| url | https://www.mdpi.com/2073-4360/15/3/656 |
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