Abstract Number ‐ 196: The Impact of Pre‐existing Depression on Functional Outcomes After Endovascular Treatment of Ischemic Stroke
Introduction Stroke is a leading cause of morbidity and mortality, and many factors predict a poor outcome, including age, NIH Stroke Scale (NIHSS), ambulatory status, and ability to swallow1. Mood disorders have previously been associated with an increased risk of cardiovascular disease2. The assoc...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-03-01
|
| Series: | Stroke: Vascular and Interventional Neurology |
| Online Access: | https://www.ahajournals.org/doi/10.1161/SVIN.03.suppl_1.196 |
| _version_ | 1797803514708099072 |
|---|---|
| author | Kara M Christopher Xiaoyi Gao Benjamin Kiaei Yongzhen Chen Brenton Hwee Wilson Rodriguez Jordan Scott Brian Miremadi Guillermo Linares |
| author_facet | Kara M Christopher Xiaoyi Gao Benjamin Kiaei Yongzhen Chen Brenton Hwee Wilson Rodriguez Jordan Scott Brian Miremadi Guillermo Linares |
| author_sort | Kara M Christopher |
| collection | DOAJ |
| description | Introduction Stroke is a leading cause of morbidity and mortality, and many factors predict a poor outcome, including age, NIH Stroke Scale (NIHSS), ambulatory status, and ability to swallow1. Mood disorders have previously been associated with an increased risk of cardiovascular disease2. The association between pre‐existing mood disorders and stroke outcome, however, has not been well studied. The objective of the current study was to explore the impact of pre‐existing depression on functional outcomes post‐endovascular treatment. Methods We reviewed the records of 178 patients who received mechanical thrombectomy (MT) at our institution[BH1][BM2] from 2019–2022. We collected data on baseline characteristics and demographics, including functional outcome at 90 days as measured by modified Rankin Scale (mRS), which was categorized as favorable (mRS 0–2) or unfavorable (mRS 3–6). Results Of patients who received MT, 54 (30.3%) had a prior medical history of depression. On univariate analysis, patients with a history of depression had 2.5 times higher odds of an mRS score of 3–6 (cOR = 2.47, 95% CI = 1.11‐5.48). Multivariate analysis included history of smoking, hypertension, obesity, Alberta Stroke Program Early CT Score (ASPECTS)[YC1][KC2], time to recanalization, and discharge NIHSS score, along with history of depression. We found that the odds of having an unfavorable mRS were 5 times higher in those with a history of depression than those with no history (aOR = 5.15, 95% CI = 1.09‐23.31). Additionally, discharge NIHSS was associated with 1.5 times higher odds of unfavorable mRS for each point increase in NIHSS score (aOR = 1.47, 95%CI = 1.25‐1.74). While pre‐existing depression was associated with poorer functional outcomes, it was not associated with mortality, cOR = 1.12, 95%CI = 0.55‐2.27. Conclusions In this study, we found that a prior medical history of depression is associated with unfavorable functional outcomes at 90 days in patients who received MT. Future studies should investigate the association between the severity of depression and stroke outcomes and explore methods to mitigate the impact of depression on stroke outcomes. |
| first_indexed | 2024-03-13T05:22:02Z |
| format | Article |
| id | doaj.art-30b080de4b5d45f3aec593b3681af7f8 |
| institution | Directory Open Access Journal |
| issn | 2694-5746 |
| language | English |
| last_indexed | 2024-03-13T05:22:02Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke: Vascular and Interventional Neurology |
| spelling | doaj.art-30b080de4b5d45f3aec593b3681af7f82023-06-15T10:40:50ZengWileyStroke: Vascular and Interventional Neurology2694-57462023-03-013S110.1161/SVIN.03.suppl_1.196Abstract Number ‐ 196: The Impact of Pre‐existing Depression on Functional Outcomes After Endovascular Treatment of Ischemic StrokeKara M Christopher0Xiaoyi Gao1Benjamin Kiaei2Yongzhen Chen3Brenton Hwee4Wilson Rodriguez5Jordan Scott6Brian Miremadi7Guillermo Linares8Saint Louis University School of Medicine St. Louis Missouri United States of AmericaSaint Louis University School of Medicine St. Louis Missouri United States of AmericaSaint Louis University School of Medicine St. Louis Missouri United States of AmericaSaint Louis University School of Medicine St. Louis Missouri United States of AmericaSaint Louis University School of Medicine St. Louis Missouri United States of AmericaSaint Louis University School of Medicine St. Louis Missouri United States of AmericaSaint Louis University School of Medicine St. Louis Missouri United States of AmericaSaint Louis University School of Medicine St. Louis Missouri United States of AmericaSSM Saint Louis University Hospital Saint Louis Missouri United States of AmericaIntroduction Stroke is a leading cause of morbidity and mortality, and many factors predict a poor outcome, including age, NIH Stroke Scale (NIHSS), ambulatory status, and ability to swallow1. Mood disorders have previously been associated with an increased risk of cardiovascular disease2. The association between pre‐existing mood disorders and stroke outcome, however, has not been well studied. The objective of the current study was to explore the impact of pre‐existing depression on functional outcomes post‐endovascular treatment. Methods We reviewed the records of 178 patients who received mechanical thrombectomy (MT) at our institution[BH1][BM2] from 2019–2022. We collected data on baseline characteristics and demographics, including functional outcome at 90 days as measured by modified Rankin Scale (mRS), which was categorized as favorable (mRS 0–2) or unfavorable (mRS 3–6). Results Of patients who received MT, 54 (30.3%) had a prior medical history of depression. On univariate analysis, patients with a history of depression had 2.5 times higher odds of an mRS score of 3–6 (cOR = 2.47, 95% CI = 1.11‐5.48). Multivariate analysis included history of smoking, hypertension, obesity, Alberta Stroke Program Early CT Score (ASPECTS)[YC1][KC2], time to recanalization, and discharge NIHSS score, along with history of depression. We found that the odds of having an unfavorable mRS were 5 times higher in those with a history of depression than those with no history (aOR = 5.15, 95% CI = 1.09‐23.31). Additionally, discharge NIHSS was associated with 1.5 times higher odds of unfavorable mRS for each point increase in NIHSS score (aOR = 1.47, 95%CI = 1.25‐1.74). While pre‐existing depression was associated with poorer functional outcomes, it was not associated with mortality, cOR = 1.12, 95%CI = 0.55‐2.27. Conclusions In this study, we found that a prior medical history of depression is associated with unfavorable functional outcomes at 90 days in patients who received MT. Future studies should investigate the association between the severity of depression and stroke outcomes and explore methods to mitigate the impact of depression on stroke outcomes.https://www.ahajournals.org/doi/10.1161/SVIN.03.suppl_1.196 |
| spellingShingle | Kara M Christopher Xiaoyi Gao Benjamin Kiaei Yongzhen Chen Brenton Hwee Wilson Rodriguez Jordan Scott Brian Miremadi Guillermo Linares Abstract Number ‐ 196: The Impact of Pre‐existing Depression on Functional Outcomes After Endovascular Treatment of Ischemic Stroke Stroke: Vascular and Interventional Neurology |
| title | Abstract Number ‐ 196: The Impact of Pre‐existing Depression on Functional Outcomes After Endovascular Treatment of Ischemic Stroke |
| title_full | Abstract Number ‐ 196: The Impact of Pre‐existing Depression on Functional Outcomes After Endovascular Treatment of Ischemic Stroke |
| title_fullStr | Abstract Number ‐ 196: The Impact of Pre‐existing Depression on Functional Outcomes After Endovascular Treatment of Ischemic Stroke |
| title_full_unstemmed | Abstract Number ‐ 196: The Impact of Pre‐existing Depression on Functional Outcomes After Endovascular Treatment of Ischemic Stroke |
| title_short | Abstract Number ‐ 196: The Impact of Pre‐existing Depression on Functional Outcomes After Endovascular Treatment of Ischemic Stroke |
| title_sort | abstract number 196 the impact of pre existing depression on functional outcomes after endovascular treatment of ischemic stroke |
| url | https://www.ahajournals.org/doi/10.1161/SVIN.03.suppl_1.196 |
| work_keys_str_mv | AT karamchristopher abstractnumber196theimpactofpreexistingdepressiononfunctionaloutcomesafterendovasculartreatmentofischemicstroke AT xiaoyigao abstractnumber196theimpactofpreexistingdepressiononfunctionaloutcomesafterendovasculartreatmentofischemicstroke AT benjaminkiaei abstractnumber196theimpactofpreexistingdepressiononfunctionaloutcomesafterendovasculartreatmentofischemicstroke AT yongzhenchen abstractnumber196theimpactofpreexistingdepressiononfunctionaloutcomesafterendovasculartreatmentofischemicstroke AT brentonhwee abstractnumber196theimpactofpreexistingdepressiononfunctionaloutcomesafterendovasculartreatmentofischemicstroke AT wilsonrodriguez abstractnumber196theimpactofpreexistingdepressiononfunctionaloutcomesafterendovasculartreatmentofischemicstroke AT jordanscott abstractnumber196theimpactofpreexistingdepressiononfunctionaloutcomesafterendovasculartreatmentofischemicstroke AT brianmiremadi abstractnumber196theimpactofpreexistingdepressiononfunctionaloutcomesafterendovasculartreatmentofischemicstroke AT guillermolinares abstractnumber196theimpactofpreexistingdepressiononfunctionaloutcomesafterendovasculartreatmentofischemicstroke |