Therapeutic Management of Metastatic Clear Cell Renal Cell Carcinoma: A Revolution in Every Decade

Therapeutic Management of Metastatic Clear Cell Renal Cell Carcinoma: A Revolution in Every Decade

Clear cell renal cell carcinoma (RCC) oncogenesis is mainly driven by <i>VHL</i> gene inactivation, leading to overexpression of vascular endothelial growth factor (VEGF). The use of tyrosine-kinase inhibitors (TKIs) directed against VEGF and its receptor (VEGFR) revolutionised the manag...

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Bibliographic Details
Main Authors: Mathieu Larroquette, Félix Lefort, Luc Heraudet, Jean-Christophe Bernhard, Alain Ravaud, Charlotte Domblides, Marine Gross-Goupil
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cancers
Subjects:
checkpoint inhibitor
combination
renal cell carcinoma
strategy
VEGF-TKI
Online Access:https://www.mdpi.com/2072-6694/14/24/6230

Internet

https://www.mdpi.com/2072-6694/14/24/6230

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