SGTA Recognizes a Noncanonical Ubiquitin-like Domain in the Bag6-Ubl4A-Trc35 Complex to Promote Endoplasmic Reticulum-Associated Degradation

SGTA Recognizes a Noncanonical Ubiquitin-like Domain in the Bag6-Ubl4A-Trc35 Complex to Promote Endoplasmic Reticulum-Associated Degradation

Elimination of aberrantly folded polypeptides from the endoplasmic reticulum (ER) by the ER-associated degradation (ERAD) system promotes cell survival under stress conditions. This quality control mechanism requires movement of misfolded proteins across the ER membrane for targeting to the cytosoli...

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Bibliographic Details
Main Authors: Yue Xu, Mengli Cai, Yingying Yang, Lan Huang, Yihong Ye
Format: Article
Language:English
Published: Elsevier 2012-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124712003919

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