Hepatic sialic acid synthesis modulates glucose homeostasis in both liver and skeletal muscle

Hepatic sialic acid synthesis modulates glucose homeostasis in both liver and skeletal muscle

Objective: Sialic acid is a terminal monosaccharide of glycans in glycoproteins and glycolipids, and its derivation from glucose is regulated by the rate-limiting enzyme UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE). Although the glycans on key endogenous hepatic proteins governing glucose metabolism a...

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Bibliographic Details
Main Authors: Jun Peng, Liming Yu, Linzhang Huang, Vivian A. Paschoal, Haiyan Chu, Camila O. de Souza, Joseph V. Varre, Da Young Oh, Jennifer J. Kohler, Xue Xiao, Lin Xu, William L. Holland, Philip W. Shaul, Chieko Mineo
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Molecular Metabolism
Subjects:
FGF21
Glucagon receptor
Glucose
GNE
Insulin receptor
Sialic acid
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877823001461

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