Lipid Metabolism in Macrophages: Focus on Atherosclerosis
Mechanisms of lipid homeostasis and its impairment are of crucial importance for atherogenesis, and their understanding is necessary for successful development of new therapeutic approaches. In the arterial wall, macrophages play a prominent role in intracellular lipid accumulation, giving rise to f...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-08-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/8/8/262 |
| _version_ | 1797560523935449088 |
|---|---|
| author | Vasily N. Sukhorukov Victoria A. Khotina Yegor S. Chegodaev Ekaterina Ivanova Igor A. Sobenin Alexander N. Orekhov |
| author_facet | Vasily N. Sukhorukov Victoria A. Khotina Yegor S. Chegodaev Ekaterina Ivanova Igor A. Sobenin Alexander N. Orekhov |
| author_sort | Vasily N. Sukhorukov |
| collection | DOAJ |
| description | Mechanisms of lipid homeostasis and its impairment are of crucial importance for atherogenesis, and their understanding is necessary for successful development of new therapeutic approaches. In the arterial wall, macrophages play a prominent role in intracellular lipid accumulation, giving rise to foam cells that populate growing atherosclerotic plaques. Under normal conditions, macrophages are able to process substantial amounts of lipids and cholesterol without critical overload of the catabolic processes. However, in atherosclerosis, these pathways become inefficient, leading to imbalance in cholesterol and lipid metabolism and disruption of cellular functions. In this review, we summarize the existing knowledge on the involvement of macrophage lipid metabolism in atherosclerosis development, including both the results of recent studies and classical concepts, and provide a detailed description of these processes from the moment of lipid uptake with lipoproteins to cholesterol efflux. |
| first_indexed | 2024-03-10T18:01:54Z |
| format | Article |
| id | doaj.art-30b4d66643ef43b1a286c2d1762da33f |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T18:01:54Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-30b4d66643ef43b1a286c2d1762da33f2023-11-20T08:48:02ZengMDPI AGBiomedicines2227-90592020-08-018826210.3390/biomedicines8080262Lipid Metabolism in Macrophages: Focus on AtherosclerosisVasily N. Sukhorukov0Victoria A. Khotina1Yegor S. Chegodaev2Ekaterina Ivanova3Igor A. Sobenin4Alexander N. Orekhov5Research Institute of Human Morphology, Laboratory of Cellular and Molecular Pathology of Cardiovascular System, 3 Tsyurupy Str., 117418 Moscow, RussiaResearch Institute of Human Morphology, Laboratory of Cellular and Molecular Pathology of Cardiovascular System, 3 Tsyurupy Str., 117418 Moscow, RussiaSechenov First Moscow State Medical University, 119146 Moscow, RussiaInstitute for Atherosclerosis Research, Skolkovo Innovative Center, 121609 Moscow, RussiaResearch Institute of Human Morphology, Laboratory of Cellular and Molecular Pathology of Cardiovascular System, 3 Tsyurupy Str., 117418 Moscow, RussiaResearch Institute of Human Morphology, Laboratory of Cellular and Molecular Pathology of Cardiovascular System, 3 Tsyurupy Str., 117418 Moscow, RussiaMechanisms of lipid homeostasis and its impairment are of crucial importance for atherogenesis, and their understanding is necessary for successful development of new therapeutic approaches. In the arterial wall, macrophages play a prominent role in intracellular lipid accumulation, giving rise to foam cells that populate growing atherosclerotic plaques. Under normal conditions, macrophages are able to process substantial amounts of lipids and cholesterol without critical overload of the catabolic processes. However, in atherosclerosis, these pathways become inefficient, leading to imbalance in cholesterol and lipid metabolism and disruption of cellular functions. In this review, we summarize the existing knowledge on the involvement of macrophage lipid metabolism in atherosclerosis development, including both the results of recent studies and classical concepts, and provide a detailed description of these processes from the moment of lipid uptake with lipoproteins to cholesterol efflux.https://www.mdpi.com/2227-9059/8/8/262lipid metabolismfoam cellmacrophageatherosclerosislipid droplet |
| spellingShingle | Vasily N. Sukhorukov Victoria A. Khotina Yegor S. Chegodaev Ekaterina Ivanova Igor A. Sobenin Alexander N. Orekhov Lipid Metabolism in Macrophages: Focus on Atherosclerosis Biomedicines lipid metabolism foam cell macrophage atherosclerosis lipid droplet |
| title | Lipid Metabolism in Macrophages: Focus on Atherosclerosis |
| title_full | Lipid Metabolism in Macrophages: Focus on Atherosclerosis |
| title_fullStr | Lipid Metabolism in Macrophages: Focus on Atherosclerosis |
| title_full_unstemmed | Lipid Metabolism in Macrophages: Focus on Atherosclerosis |
| title_short | Lipid Metabolism in Macrophages: Focus on Atherosclerosis |
| title_sort | lipid metabolism in macrophages focus on atherosclerosis |
| topic | lipid metabolism foam cell macrophage atherosclerosis lipid droplet |
| url | https://www.mdpi.com/2227-9059/8/8/262 |
| work_keys_str_mv | AT vasilynsukhorukov lipidmetabolisminmacrophagesfocusonatherosclerosis AT victoriaakhotina lipidmetabolisminmacrophagesfocusonatherosclerosis AT yegorschegodaev lipidmetabolisminmacrophagesfocusonatherosclerosis AT ekaterinaivanova lipidmetabolisminmacrophagesfocusonatherosclerosis AT igorasobenin lipidmetabolisminmacrophagesfocusonatherosclerosis AT alexandernorekhov lipidmetabolisminmacrophagesfocusonatherosclerosis |