Is there an association between inflammatory markers and lower physical performance in older adults?
Abstract Background Maintenance of physical performance is essential for achievement of healthy aging. A few studies have explored the association between inflammatory markers and physical performance in older adults with inconclusive results. Our aim was to analyze the association of tumor necrosis...
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12877-022-03091-7 |
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| author | Betty Manrique-Espinoza Rosa Palazuelos-González Victoria Pando-Robles Oscar Rosas-Carrasco Aarón Salinas-Rodríguez |
| author_facet | Betty Manrique-Espinoza Rosa Palazuelos-González Victoria Pando-Robles Oscar Rosas-Carrasco Aarón Salinas-Rodríguez |
| author_sort | Betty Manrique-Espinoza |
| collection | DOAJ |
| description | Abstract Background Maintenance of physical performance is essential for achievement of healthy aging. A few studies have explored the association between inflammatory markers and physical performance in older adults with inconclusive results. Our aim was to analyze the association of tumor necrosis factor-alpha (TNF-α), Interleukin-10 (IL-10), and C-reactive protein (CRP) with physical performance in a sample of older adults in rural settings of Mexico. Methods Our study comprised 307 community-dwelling older men and women who participated in the third wave of the Rural Frailty Study. We assessed the physical performance with the Short Physical Performance Battery (SPPB) and classified older adults as low performance if SPPB scored ≤8. Inflammatory markers were ascertained using serum by immunodetection methods. Logistic regression models were used to estimate the associations between inflammatory markers and physical performance. Results In comparison with the normal physical performance group, low physical performance individuals mainly were female (P < 0.01), older (P < 0.01), more illiterate (P = 0.02), more hypertensive (P < 0.01), fewer smokers (P = 0.02), and had higher CRP levels (P < 0.01). The logistic model results showed a significant association between the 3rd tertile of CRP and low physical performance (OR = 2.23; P = 0.03). IL-10 and TNF-α levels did not show a significant association. Conclusions The results of this study were mixed, with a significant association of physical performance with higher CRP levels but nonsignificant with IL-10 and TNF-α. Further studies with improved designs are needed by incorporating a broader set of inflammatory markers. |
| first_indexed | 2024-04-13T08:34:18Z |
| format | Article |
| id | doaj.art-30b6aefd3a0e4f9683fe859d174e108c |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-04-13T08:34:18Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-30b6aefd3a0e4f9683fe859d174e108c2022-12-22T02:54:10ZengBMCBMC Geriatrics1471-23182022-05-012211710.1186/s12877-022-03091-7Is there an association between inflammatory markers and lower physical performance in older adults?Betty Manrique-Espinoza0Rosa Palazuelos-González1Victoria Pando-Robles2Oscar Rosas-Carrasco3Aarón Salinas-Rodríguez4Center for Evaluation and Surveys Research, National Institute of Public HealthCenter for Evaluation and Surveys Research, National Institute of Public HealthCenter for Infectious Diseases, National Institute of Public HealthHealth Department, Universidad IberoamericanaCenter for Evaluation and Surveys Research, National Institute of Public HealthAbstract Background Maintenance of physical performance is essential for achievement of healthy aging. A few studies have explored the association between inflammatory markers and physical performance in older adults with inconclusive results. Our aim was to analyze the association of tumor necrosis factor-alpha (TNF-α), Interleukin-10 (IL-10), and C-reactive protein (CRP) with physical performance in a sample of older adults in rural settings of Mexico. Methods Our study comprised 307 community-dwelling older men and women who participated in the third wave of the Rural Frailty Study. We assessed the physical performance with the Short Physical Performance Battery (SPPB) and classified older adults as low performance if SPPB scored ≤8. Inflammatory markers were ascertained using serum by immunodetection methods. Logistic regression models were used to estimate the associations between inflammatory markers and physical performance. Results In comparison with the normal physical performance group, low physical performance individuals mainly were female (P < 0.01), older (P < 0.01), more illiterate (P = 0.02), more hypertensive (P < 0.01), fewer smokers (P = 0.02), and had higher CRP levels (P < 0.01). The logistic model results showed a significant association between the 3rd tertile of CRP and low physical performance (OR = 2.23; P = 0.03). IL-10 and TNF-α levels did not show a significant association. Conclusions The results of this study were mixed, with a significant association of physical performance with higher CRP levels but nonsignificant with IL-10 and TNF-α. Further studies with improved designs are needed by incorporating a broader set of inflammatory markers.https://doi.org/10.1186/s12877-022-03091-7Physical performanceInflammationInterleukin-10Tumor necrosis factor-alphaC-reactive protein |
| spellingShingle | Betty Manrique-Espinoza Rosa Palazuelos-González Victoria Pando-Robles Oscar Rosas-Carrasco Aarón Salinas-Rodríguez Is there an association between inflammatory markers and lower physical performance in older adults? BMC Geriatrics Physical performance Inflammation Interleukin-10 Tumor necrosis factor-alpha C-reactive protein |
| title | Is there an association between inflammatory markers and lower physical performance in older adults? |
| title_full | Is there an association between inflammatory markers and lower physical performance in older adults? |
| title_fullStr | Is there an association between inflammatory markers and lower physical performance in older adults? |
| title_full_unstemmed | Is there an association between inflammatory markers and lower physical performance in older adults? |
| title_short | Is there an association between inflammatory markers and lower physical performance in older adults? |
| title_sort | is there an association between inflammatory markers and lower physical performance in older adults |
| topic | Physical performance Inflammation Interleukin-10 Tumor necrosis factor-alpha C-reactive protein |
| url | https://doi.org/10.1186/s12877-022-03091-7 |
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