Supplementation of Crataegi fructus alleviates functional dyspepsia and restores gut microbiota in mice
IntroductionFunctional dyspepsia (FD), also known as non-ulcerative dyspepsia, is a common digestive system disorder.MethodsIn this study, an FD model was established using hunger and satiety disorders combined with an intraperitoneal injection of L-arginine. Indices used to evaluate the efficacy of...
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1385159/full |
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| author | Liyu Hao Liyu Hao Zeyue Yu Jianhui Sun Zongyuan Li Zongyuan Li Jianliang Li Yurong Deng Hanhui Huang Hairu Huo Hongmei Li Luqi Huang |
| author_facet | Liyu Hao Liyu Hao Zeyue Yu Jianhui Sun Zongyuan Li Zongyuan Li Jianliang Li Yurong Deng Hanhui Huang Hairu Huo Hongmei Li Luqi Huang |
| author_sort | Liyu Hao |
| collection | DOAJ |
| description | IntroductionFunctional dyspepsia (FD), also known as non-ulcerative dyspepsia, is a common digestive system disorder.MethodsIn this study, an FD model was established using hunger and satiety disorders combined with an intraperitoneal injection of L-arginine. Indices used to evaluate the efficacy of hawthorn in FD mice include small intestinal propulsion rate, gastric residual rate, general condition, food intake, amount of drinking water, gastric histopathological examination, and serum nitric oxide (NO) and gastrin levels. Based on the intestinal flora and their metabolites, short-chain fatty acids (SCFAs), the mechanism of action of Crataegi Fructus (hawthorn) on FD was studied. The fecal microbiota transplantation test was used to verify whether hawthorn altered the structure of the intestinal flora.ResultsThe results showed that hawthorn improved FD by significantly reducing the gastric residual rate, increasing the intestinal propulsion rate, the intake of food and drinking water, and the levels of gastrointestinal hormones. Simultaneously, hawthorn elevated substance P and 5-hydroxytryptamine expression in the duodenum, reduced serum NO levels, and increased vasoactive intestinal peptide expression in the duodenum. Notably, hawthorn increased the abundance of beneficial bacteria and SCFA-producing bacteria in the intestines of FD mice, decreased the abundance of conditional pathogenic bacteria, and significantly increased the SCFA content in feces.DiscussionThe mechanism by which hawthorn improves FD may be related to the regulation of intestinal flora structure and the production of SCFAs. |
| first_indexed | 2024-04-24T15:29:40Z |
| format | Article |
| id | doaj.art-30b70c7362cd42cc896d883119da99eb |
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| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-24T15:29:40Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-30b70c7362cd42cc896d883119da99eb2024-04-02T04:43:20ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-04-011110.3389/fnut.2024.13851591385159Supplementation of Crataegi fructus alleviates functional dyspepsia and restores gut microbiota in miceLiyu Hao0Liyu Hao1Zeyue Yu2Jianhui Sun3Zongyuan Li4Zongyuan Li5Jianliang Li6Yurong Deng7Hanhui Huang8Hairu Huo9Hongmei Li10Luqi Huang11School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, ChinaChina Academy of Chinese Medical Sciences, Beijing, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, ChinaChina Academy of Chinese Medical Sciences, Beijing, ChinaIntroductionFunctional dyspepsia (FD), also known as non-ulcerative dyspepsia, is a common digestive system disorder.MethodsIn this study, an FD model was established using hunger and satiety disorders combined with an intraperitoneal injection of L-arginine. Indices used to evaluate the efficacy of hawthorn in FD mice include small intestinal propulsion rate, gastric residual rate, general condition, food intake, amount of drinking water, gastric histopathological examination, and serum nitric oxide (NO) and gastrin levels. Based on the intestinal flora and their metabolites, short-chain fatty acids (SCFAs), the mechanism of action of Crataegi Fructus (hawthorn) on FD was studied. The fecal microbiota transplantation test was used to verify whether hawthorn altered the structure of the intestinal flora.ResultsThe results showed that hawthorn improved FD by significantly reducing the gastric residual rate, increasing the intestinal propulsion rate, the intake of food and drinking water, and the levels of gastrointestinal hormones. Simultaneously, hawthorn elevated substance P and 5-hydroxytryptamine expression in the duodenum, reduced serum NO levels, and increased vasoactive intestinal peptide expression in the duodenum. Notably, hawthorn increased the abundance of beneficial bacteria and SCFA-producing bacteria in the intestines of FD mice, decreased the abundance of conditional pathogenic bacteria, and significantly increased the SCFA content in feces.DiscussionThe mechanism by which hawthorn improves FD may be related to the regulation of intestinal flora structure and the production of SCFAs.https://www.frontiersin.org/articles/10.3389/fnut.2024.1385159/fullCrataegi fructusfunctional dyspepsiagut microbiotashort-chain fatty acidsfecal microbiota transplantation |
| spellingShingle | Liyu Hao Liyu Hao Zeyue Yu Jianhui Sun Zongyuan Li Zongyuan Li Jianliang Li Yurong Deng Hanhui Huang Hairu Huo Hongmei Li Luqi Huang Supplementation of Crataegi fructus alleviates functional dyspepsia and restores gut microbiota in mice Frontiers in Nutrition Crataegi fructus functional dyspepsia gut microbiota short-chain fatty acids fecal microbiota transplantation |
| title | Supplementation of Crataegi fructus alleviates functional dyspepsia and restores gut microbiota in mice |
| title_full | Supplementation of Crataegi fructus alleviates functional dyspepsia and restores gut microbiota in mice |
| title_fullStr | Supplementation of Crataegi fructus alleviates functional dyspepsia and restores gut microbiota in mice |
| title_full_unstemmed | Supplementation of Crataegi fructus alleviates functional dyspepsia and restores gut microbiota in mice |
| title_short | Supplementation of Crataegi fructus alleviates functional dyspepsia and restores gut microbiota in mice |
| title_sort | supplementation of crataegi fructus alleviates functional dyspepsia and restores gut microbiota in mice |
| topic | Crataegi fructus functional dyspepsia gut microbiota short-chain fatty acids fecal microbiota transplantation |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1385159/full |
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