CLL-Derived Extracellular Vesicles Impair T-Cell Activation and Foster T-Cell Exhaustion via Multiple Immunological Checkpoints

CLL-Derived Extracellular Vesicles Impair T-Cell Activation and Foster T-Cell Exhaustion via Multiple Immunological Checkpoints

<i>Background:</i> Chronic lymphocytic leukemia (CLL) is characterized by the clonal expansion of malignant B-cells and multiple immune defects. This leads, among others, to severe infectious complications and inefficient immune surveillance. T-cell deficiencies in CLL include enhanced i...

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Bibliographic Details
Main Authors: Martin Böttcher, Romy Böttcher-Loschinski, Sascha Kahlfuss, Michael Aigner, Andreas Gießl, Andreas Mackensen, Ursula Schlötzer-Schrehardt, Thomas Tüting, Heiko Bruns, Dimitrios Mougiakakos
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cells
Subjects:
chronic lymphocytic leukemia
extracellular vesicles
T-cells
immune evasion
immune checkpoints
cellular therapy
Online Access:https://www.mdpi.com/2073-4409/11/14/2176

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