Maternal Group B Streptococcal Rectovaginal Colonization after Intrapartum Antibiotic Prophylaxis
Maternal rectovaginal colonization with Group B Streptococcus (GBS) during labor is a prerequisite for neonatal early-onset GBS disease. Intrapartum antibiotic prophylaxis (IAP) has been proven to prevent GBS perinatal infection, while there are few studies on the evaluation of the effectiveness of...
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MDPI AG
2022-11-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/9/12/1848 |
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| author | Ping Liu Qiaoli Feng Yiheng Liang Xinxin Wang Zhansong Xiao Liting Huang Yun Li Yuqing Deng Lin Yu Yang Xin Shangrong Fan |
| author_facet | Ping Liu Qiaoli Feng Yiheng Liang Xinxin Wang Zhansong Xiao Liting Huang Yun Li Yuqing Deng Lin Yu Yang Xin Shangrong Fan |
| author_sort | Ping Liu |
| collection | DOAJ |
| description | Maternal rectovaginal colonization with Group B Streptococcus (GBS) during labor is a prerequisite for neonatal early-onset GBS disease. Intrapartum antibiotic prophylaxis (IAP) has been proven to prevent GBS perinatal infection, while there are few studies on the evaluation of the effectiveness of different antibiotic prophylaxis regimens. This study aimed to assess the maternal rectovaginal GBS colonization status after IAP, antimicrobial susceptibility and maternal and neonatal outcomes among women administered different antibiotic prophylaxis regimens. A prospective study was conducted between June 2018 and June 2022. GBS carriers identified at 35–37 weeks of gestation were provided IAP (penicillin, cefazolin or clindamycin) at delivery based on the local protocol for GBS prevention. Rectovaginal samples were obtained from participants again after delivery. Antimicrobial susceptibility testing in GBS isolates was performed using the broth microdilution method. A total of 295 cases were included in this study. In the postpartum re-examination for GBS, the overall negative rectovaginal culture rate was 90.8% (268/295). Women who received cefazolin prophylaxis had the highest negative culture rate (95.2%, 197/207), which was followed by those who received penicillin (80.7%, 67/83) and clindamycin (80.0%, 4/5) (<i>p</i> = 0.001). All GBS isolates achieved sensitivity to penicillin and cefazolin, whereas resistance to clindamycin was shown in 21.4% of the strains. There were no significant differences in maternal and neonatal outcomes among the IAP groups. The use of IAP is highly effective in reducing the maternal rectovaginal GBS colonization. Cefazolin may offer equivalent efficacy and safety compared to standard penicillin prophylaxis. |
| first_indexed | 2024-03-09T17:11:11Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-09T17:11:11Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-30b7da027c2246d3a4969de292b02cd92023-11-24T14:00:47ZengMDPI AGChildren2227-90672022-11-01912184810.3390/children9121848Maternal Group B Streptococcal Rectovaginal Colonization after Intrapartum Antibiotic ProphylaxisPing Liu0Qiaoli Feng1Yiheng Liang2Xinxin Wang3Zhansong Xiao4Liting Huang5Yun Li6Yuqing Deng7Lin Yu8Yang Xin9Shangrong Fan10Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen 518036, ChinaDepartment of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen 518036, ChinaDepartment of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen 518036, ChinaDepartment of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen 518036, ChinaDepartment of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen 518036, ChinaDepartment of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen 518036, ChinaDepartment of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen 518036, ChinaDepartment of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen 518036, ChinaDepartment of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen 518036, ChinaDepartment of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen 518036, ChinaDepartment of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen 518036, ChinaMaternal rectovaginal colonization with Group B Streptococcus (GBS) during labor is a prerequisite for neonatal early-onset GBS disease. Intrapartum antibiotic prophylaxis (IAP) has been proven to prevent GBS perinatal infection, while there are few studies on the evaluation of the effectiveness of different antibiotic prophylaxis regimens. This study aimed to assess the maternal rectovaginal GBS colonization status after IAP, antimicrobial susceptibility and maternal and neonatal outcomes among women administered different antibiotic prophylaxis regimens. A prospective study was conducted between June 2018 and June 2022. GBS carriers identified at 35–37 weeks of gestation were provided IAP (penicillin, cefazolin or clindamycin) at delivery based on the local protocol for GBS prevention. Rectovaginal samples were obtained from participants again after delivery. Antimicrobial susceptibility testing in GBS isolates was performed using the broth microdilution method. A total of 295 cases were included in this study. In the postpartum re-examination for GBS, the overall negative rectovaginal culture rate was 90.8% (268/295). Women who received cefazolin prophylaxis had the highest negative culture rate (95.2%, 197/207), which was followed by those who received penicillin (80.7%, 67/83) and clindamycin (80.0%, 4/5) (<i>p</i> = 0.001). All GBS isolates achieved sensitivity to penicillin and cefazolin, whereas resistance to clindamycin was shown in 21.4% of the strains. There were no significant differences in maternal and neonatal outcomes among the IAP groups. The use of IAP is highly effective in reducing the maternal rectovaginal GBS colonization. Cefazolin may offer equivalent efficacy and safety compared to standard penicillin prophylaxis.https://www.mdpi.com/2227-9067/9/12/1848colonizationgroup b streptococcusintrapartum antibiotic prophylaxis |
| spellingShingle | Ping Liu Qiaoli Feng Yiheng Liang Xinxin Wang Zhansong Xiao Liting Huang Yun Li Yuqing Deng Lin Yu Yang Xin Shangrong Fan Maternal Group B Streptococcal Rectovaginal Colonization after Intrapartum Antibiotic Prophylaxis Children colonization group b streptococcus intrapartum antibiotic prophylaxis |
| title | Maternal Group B Streptococcal Rectovaginal Colonization after Intrapartum Antibiotic Prophylaxis |
| title_full | Maternal Group B Streptococcal Rectovaginal Colonization after Intrapartum Antibiotic Prophylaxis |
| title_fullStr | Maternal Group B Streptococcal Rectovaginal Colonization after Intrapartum Antibiotic Prophylaxis |
| title_full_unstemmed | Maternal Group B Streptococcal Rectovaginal Colonization after Intrapartum Antibiotic Prophylaxis |
| title_short | Maternal Group B Streptococcal Rectovaginal Colonization after Intrapartum Antibiotic Prophylaxis |
| title_sort | maternal group b streptococcal rectovaginal colonization after intrapartum antibiotic prophylaxis |
| topic | colonization group b streptococcus intrapartum antibiotic prophylaxis |
| url | https://www.mdpi.com/2227-9067/9/12/1848 |
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