Prognostic impact of intra- and peritumoral immune cell subpopulations in head and neck squamous cell carcinomas – comprehensive analysis of the TCGA-HNSC cohort and immunohistochemical validation on 101 patients

Prognostic impact of intra- and peritumoral immune cell subpopulations in head and neck squamous cell carcinomas – comprehensive analysis of the TCGA-HNSC cohort and immunohistochemical validation on 101 patients

BackgroundDue to the expanding role of immune checkpoint inhibition in the treatment of head and neck squamous cell carcinoma, understanding immunological processes in the tumor microevironment (TME) has strong translational importance. Though analytical methods for a comprehensive analysis of the i...

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Bibliographic Details
Main Authors: Moritz Knebel, Sandrina Körner, Jan Philipp Kühn, Silke Wemmert, Lukas Brust, Sigrun Smola, Mathias Wagner, Rainer M. Bohle, Luc G. T. Morris, Abhinav Pandey, Bernhard Schick, Maximilian Linxweiler
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
HNSCC (head and neck squamous cell carcinoma)
immunotherapy
The Cancer Genome Atlas
immunological tumor microenvironment
prognostic biomarkers
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1172768/full

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