Nasal Nitric Oxide in Children: A Review of Current Outreach in Pediatric Respiratory Medicine
Nasal nitric oxide (nNO) is a gas synthesized by the inducible and constitutive NO synthase (NOS) enzyme in the airway cells of the nasal mucosa. Like lung nitric oxide, it is thought to be associated with airway inflammation in various respiratory diseases in children. The aim of our review was to...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/10/10/1671 |
| _version_ | 1797574256292265984 |
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| author | Iva Mrkić Kobal Mirjana Turkalj Davor Plavec |
| author_facet | Iva Mrkić Kobal Mirjana Turkalj Davor Plavec |
| author_sort | Iva Mrkić Kobal |
| collection | DOAJ |
| description | Nasal nitric oxide (nNO) is a gas synthesized by the inducible and constitutive NO synthase (NOS) enzyme in the airway cells of the nasal mucosa. Like lung nitric oxide, it is thought to be associated with airway inflammation in various respiratory diseases in children. The aim of our review was to investigate the current state of use of nNO measurement in children. A comprehensive search was conducted using the Web of Science and PubMed databases specifically targeting publications in the English language, with the following keywords: nasal NO, children, allergic rhinitis, chronic rhinosinusitis, acute rhinosinusitis, primary ciliary dyskinesia (PCD), and cystic fibrosis (CF). We describe the use of nNO in pediatric allergic rhinitis, chronic rhinosinusitis, acute rhinosinusitis, PCD, and CF based on the latest literature. nNO is a noninvasive, clinically applicable test for use in pediatric allergic rhinitis, chronic rhinosinusitis, acute rhinosinusitis, PCD, and CF. It can be used as a complementary method in the diagnosis of these respiratory diseases and as a monitoring method for the treatment of allergic rhinitis and acute and chronic rhinosinusitis. |
| first_indexed | 2024-03-10T21:20:26Z |
| format | Article |
| id | doaj.art-30bb06565d404579b3febc77a05dcd24 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T21:20:26Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-30bb06565d404579b3febc77a05dcd242023-11-19T16:05:25ZengMDPI AGChildren2227-90672023-10-011010167110.3390/children10101671Nasal Nitric Oxide in Children: A Review of Current Outreach in Pediatric Respiratory MedicineIva Mrkić Kobal0Mirjana Turkalj1Davor Plavec2Outpatient Clinic for Sick Children Dr. Sabol, 10000 Zagreb, CroatiaFaculty of Medicine, JJ Strossmayer University of Osijek, 31000 Osijek, CroatiaFaculty of Medicine, JJ Strossmayer University of Osijek, 31000 Osijek, CroatiaNasal nitric oxide (nNO) is a gas synthesized by the inducible and constitutive NO synthase (NOS) enzyme in the airway cells of the nasal mucosa. Like lung nitric oxide, it is thought to be associated with airway inflammation in various respiratory diseases in children. The aim of our review was to investigate the current state of use of nNO measurement in children. A comprehensive search was conducted using the Web of Science and PubMed databases specifically targeting publications in the English language, with the following keywords: nasal NO, children, allergic rhinitis, chronic rhinosinusitis, acute rhinosinusitis, primary ciliary dyskinesia (PCD), and cystic fibrosis (CF). We describe the use of nNO in pediatric allergic rhinitis, chronic rhinosinusitis, acute rhinosinusitis, PCD, and CF based on the latest literature. nNO is a noninvasive, clinically applicable test for use in pediatric allergic rhinitis, chronic rhinosinusitis, acute rhinosinusitis, PCD, and CF. It can be used as a complementary method in the diagnosis of these respiratory diseases and as a monitoring method for the treatment of allergic rhinitis and acute and chronic rhinosinusitis.https://www.mdpi.com/2227-9067/10/10/1671nasal nitric oxidechildrenallergic rhinitischronic rhinosinusitisprimary ciliary dyskinesiacystic fibrosis |
| spellingShingle | Iva Mrkić Kobal Mirjana Turkalj Davor Plavec Nasal Nitric Oxide in Children: A Review of Current Outreach in Pediatric Respiratory Medicine Children nasal nitric oxide children allergic rhinitis chronic rhinosinusitis primary ciliary dyskinesia cystic fibrosis |
| title | Nasal Nitric Oxide in Children: A Review of Current Outreach in Pediatric Respiratory Medicine |
| title_full | Nasal Nitric Oxide in Children: A Review of Current Outreach in Pediatric Respiratory Medicine |
| title_fullStr | Nasal Nitric Oxide in Children: A Review of Current Outreach in Pediatric Respiratory Medicine |
| title_full_unstemmed | Nasal Nitric Oxide in Children: A Review of Current Outreach in Pediatric Respiratory Medicine |
| title_short | Nasal Nitric Oxide in Children: A Review of Current Outreach in Pediatric Respiratory Medicine |
| title_sort | nasal nitric oxide in children a review of current outreach in pediatric respiratory medicine |
| topic | nasal nitric oxide children allergic rhinitis chronic rhinosinusitis primary ciliary dyskinesia cystic fibrosis |
| url | https://www.mdpi.com/2227-9067/10/10/1671 |
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