Cannabinoid signaling modulation through JZL184 restores key phenotypes of a mouse model for Williams–Beuren syndrome

Cannabinoid signaling modulation through JZL184 restores key phenotypes of a mouse model for Williams–Beuren syndrome

Williams–Beuren syndrome (WBS) is a rare genetic multisystemic disorder characterized by mild-to-moderate intellectual disability and hypersocial phenotype, while the most life-threatening features are cardiovascular abnormalities. Nowadays, there are no pharmacological treatments to directly amelio...

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Bibliographic Details
Main Authors: Alba Navarro-Romero, Lorena Galera-López, Paula Ortiz-Romero, Alberto Llorente-Ovejero, Lucía de los Reyes-Ramírez, Iker Bengoetxea de Tena, Anna Garcia-Elias, Aleksandra Mas-Stachurska, Marina Reixachs-Solé, Antoni Pastor, Rafael de la Torre, Rafael Maldonado, Begoña Benito, Eduardo Eyras, Rafael Rodríguez-Puertas, Victoria Campuzano, Andres Ozaita
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-10-01
Series:eLife
Subjects:
Williams–Beuren syndrome
intellectual disability
endocannabinoid system
cannabinoid type-1 receptor
Online Access:https://elifesciences.org/articles/72560

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