Alzheimer disease-associated cystatin C variant undergoes impaired secretion

Alzheimer disease-associated cystatin C variant undergoes impaired secretion

CST3 is the coding gene for cystatin C (CysC). CST3 B/B homozygosity is associated with an increased risk of developing Alzheimer disease. We performed CysC analysis on human primary skin fibroblasts obtained from donors carrying A/A, A/B, and B/B CST3. Pulse-chase experiments demonstrated that the...

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Main Authors: Luisa Benussi, Roberta Ghidoni, Tiana Steinhoff, Antonella Alberici, Aldo Villa, Federica Mazzoli, Francesca Nicosia, Laura Barbiero, Laura Broglio, Enrica Feudatari, Simona Signorini, Ulrich Finckh, Roger M. Nitsch, Giuliano Binetti
Format: Article
Language:English
Published: Elsevier 2003-06-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103000123

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