Immune defects in the risk of infection and response to vaccination in monoclonal gammopathy of undetermined significance and multiple myeloma
The plasma cell proliferative disorders monoclonal gammopathy of undetermined significance (MGUS) and malignant multiple myeloma (MM) are characterized by an accumulation of transformed clonal plasma cells in the bone marrow and production of monoclonal immunoglobulin. They typically affect an older...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-06-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00257/full |
| _version_ | 1818522143245205504 |
|---|---|
| author | Sarah eTete Marc eBijl Surinder eSahota Nicolaas Adrianus Bos |
| author_facet | Sarah eTete Marc eBijl Surinder eSahota Nicolaas Adrianus Bos |
| author_sort | Sarah eTete |
| collection | DOAJ |
| description | The plasma cell proliferative disorders monoclonal gammopathy of undetermined significance (MGUS) and malignant multiple myeloma (MM) are characterized by an accumulation of transformed clonal plasma cells in the bone marrow and production of monoclonal immunoglobulin. They typically affect an older population, with median age of diagnosis of approximately 70 years. In both disorders, there is an increased risk of infection due to the immunosuppressive effects of disease and conjointly of therapy in MM, and response to vaccination to counter infection is compromised. The underlying factors in a weakened immune response in MGUS and MM are as yet not fully understood. A confounding factor is the onset of normal aging, which quantitatively and qualitatively hampers humoral immunity to affect response to infection and vaccination. In this review, we examine the status of immune alterations in MGUS and MM and set these against normal aging immune responses. We focus primarily on quantitative and functional aspects of B-cell immunity. Furthermore, we review the current knowledge relating to susceptibility to infectious disease in MGUS and MM, and how efficacy of conventional vaccination is affected by proliferative disease-related and therapy-related factors. |
| first_indexed | 2024-12-11T05:29:25Z |
| format | Article |
| id | doaj.art-30c0aba67e894a70ba7d312a942e4724 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T05:29:25Z |
| publishDate | 2014-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-30c0aba67e894a70ba7d312a942e47242022-12-22T01:19:29ZengFrontiers Media S.A.Frontiers in Immunology1664-32242014-06-01510.3389/fimmu.2014.0025787870Immune defects in the risk of infection and response to vaccination in monoclonal gammopathy of undetermined significance and multiple myelomaSarah eTete0Marc eBijl1Surinder eSahota2Nicolaas Adrianus Bos3University of Groningen, University Medical Center GroningenMartini HospitalUniversity of SouthamptonUniversity of Groningen, University Medical Center GroningenThe plasma cell proliferative disorders monoclonal gammopathy of undetermined significance (MGUS) and malignant multiple myeloma (MM) are characterized by an accumulation of transformed clonal plasma cells in the bone marrow and production of monoclonal immunoglobulin. They typically affect an older population, with median age of diagnosis of approximately 70 years. In both disorders, there is an increased risk of infection due to the immunosuppressive effects of disease and conjointly of therapy in MM, and response to vaccination to counter infection is compromised. The underlying factors in a weakened immune response in MGUS and MM are as yet not fully understood. A confounding factor is the onset of normal aging, which quantitatively and qualitatively hampers humoral immunity to affect response to infection and vaccination. In this review, we examine the status of immune alterations in MGUS and MM and set these against normal aging immune responses. We focus primarily on quantitative and functional aspects of B-cell immunity. Furthermore, we review the current knowledge relating to susceptibility to infectious disease in MGUS and MM, and how efficacy of conventional vaccination is affected by proliferative disease-related and therapy-related factors.http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00257/fullMultiple MyelomaVaccinationInfectionsMGUSimmune defects |
| spellingShingle | Sarah eTete Marc eBijl Surinder eSahota Nicolaas Adrianus Bos Immune defects in the risk of infection and response to vaccination in monoclonal gammopathy of undetermined significance and multiple myeloma Frontiers in Immunology Multiple Myeloma Vaccination Infections MGUS immune defects |
| title | Immune defects in the risk of infection and response to vaccination in monoclonal gammopathy of undetermined significance and multiple myeloma |
| title_full | Immune defects in the risk of infection and response to vaccination in monoclonal gammopathy of undetermined significance and multiple myeloma |
| title_fullStr | Immune defects in the risk of infection and response to vaccination in monoclonal gammopathy of undetermined significance and multiple myeloma |
| title_full_unstemmed | Immune defects in the risk of infection and response to vaccination in monoclonal gammopathy of undetermined significance and multiple myeloma |
| title_short | Immune defects in the risk of infection and response to vaccination in monoclonal gammopathy of undetermined significance and multiple myeloma |
| title_sort | immune defects in the risk of infection and response to vaccination in monoclonal gammopathy of undetermined significance and multiple myeloma |
| topic | Multiple Myeloma Vaccination Infections MGUS immune defects |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00257/full |
| work_keys_str_mv | AT sarahetete immunedefectsintheriskofinfectionandresponsetovaccinationinmonoclonalgammopathyofundeterminedsignificanceandmultiplemyeloma AT marcebijl immunedefectsintheriskofinfectionandresponsetovaccinationinmonoclonalgammopathyofundeterminedsignificanceandmultiplemyeloma AT surinderesahota immunedefectsintheriskofinfectionandresponsetovaccinationinmonoclonalgammopathyofundeterminedsignificanceandmultiplemyeloma AT nicolaasadrianusbos immunedefectsintheriskofinfectionandresponsetovaccinationinmonoclonalgammopathyofundeterminedsignificanceandmultiplemyeloma |