Analysis of docosanol using GC/MS: Method development, validation, and application to ex vivo human skin permeation studies

Analysis of docosanol using GC/MS: Method development, validation, and application to ex vivo human skin permeation studies

Docosanol is the only US Food and Drug Administration (FDA) approved over-the-counter topical product for treating recurrent oral-facial herpes simplex labialis. Validated analytical methods for docosanol are required to demonstrate the bioequivalence of docosanol topical products. A gas chromatogra...

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Bibliographic Details
Main Authors: Vijay Kumar Shankar, Mei Wang, Srinivas Ajjarapu, Praveen Kolimi, Bharathi Avula, Reena Murthy, Ikhlas Khan, Sathyanarayana Narasimha Murthy
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Docosanol
Fatty alcohols
Gas chromatography-mass spectrometry
Topical formulation
Skin permeation
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177921000903

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