Amino acids levels as a potential biomarker in myasthenia gravis
The search for new diagnostic and therapeutic approaches for myasthenia gravis (MG) is highly desirable. Therefore, the aim of the present study is to assess the profile of non-essential amino acids in the serum of MG patients. We evaluated the serum levels of non-essential amino acids in MG patient...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2022-03-01
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| Series: | Folia Neuropathologica |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Amino-acids-levels-as-a-potential-biomarker-in-myasthenia-gravis,20,46501,1,1.html |
| _version_ | 1817986326961586176 |
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| author | Piotr Kośliński Łukasz Rzepiński Marcin Koba Marcin Gackowski Zdzisław Maciejek |
| author_facet | Piotr Kośliński Łukasz Rzepiński Marcin Koba Marcin Gackowski Zdzisław Maciejek |
| author_sort | Piotr Kośliński |
| collection | DOAJ |
| description | The search for new diagnostic and therapeutic approaches for myasthenia gravis (MG) is highly desirable. Therefore, the aim of the present study is to assess the profile of non-essential amino acids in the serum of MG patients. We evaluated the serum levels of non-essential amino acids in MG patients (n = 10) and control subjects (CS, n = 10) using high-performance liquid chromatography (HPLC) method and assuming a two-fold concentration difference between the groups as significant. Serum levels of aspartic acid and glutamic acid in MG patients were significantly higher than in CS. There were no significant differences in mean serum levels of glycine, proline, alanine, serine, cysteine, arginine and tyrosine between MG patients and CS. The results indicate the need for further research to assess the role of non-essential amino acids in MG. Moreover, our preliminary results suggest that the metabolism of some amino acids seems to be changed in patients with MG. Therefore, we conclude that amino acids profiling might be helpful in searching for putative biomarkers of the central nervous system diseases such as myasthenia gravis. |
| first_indexed | 2024-04-14T00:08:24Z |
| format | Article |
| id | doaj.art-30c3ad858e5740cf9acd81ad114a6ceb |
| institution | Directory Open Access Journal |
| issn | 1641-4640 1509-572X |
| language | English |
| last_indexed | 2024-04-14T00:08:24Z |
| publishDate | 2022-03-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Folia Neuropathologica |
| spelling | doaj.art-30c3ad858e5740cf9acd81ad114a6ceb2022-12-22T02:23:27ZengTermedia Publishing HouseFolia Neuropathologica1641-46401509-572X2022-03-0160112212710.5114/fn.2022.11405346501Amino acids levels as a potential biomarker in myasthenia gravisPiotr KoślińskiŁukasz RzepińskiMarcin KobaMarcin GackowskiZdzisław MaciejekThe search for new diagnostic and therapeutic approaches for myasthenia gravis (MG) is highly desirable. Therefore, the aim of the present study is to assess the profile of non-essential amino acids in the serum of MG patients. We evaluated the serum levels of non-essential amino acids in MG patients (n = 10) and control subjects (CS, n = 10) using high-performance liquid chromatography (HPLC) method and assuming a two-fold concentration difference between the groups as significant. Serum levels of aspartic acid and glutamic acid in MG patients were significantly higher than in CS. There were no significant differences in mean serum levels of glycine, proline, alanine, serine, cysteine, arginine and tyrosine between MG patients and CS. The results indicate the need for further research to assess the role of non-essential amino acids in MG. Moreover, our preliminary results suggest that the metabolism of some amino acids seems to be changed in patients with MG. Therefore, we conclude that amino acids profiling might be helpful in searching for putative biomarkers of the central nervous system diseases such as myasthenia gravis.https://www.termedia.pl/Amino-acids-levels-as-a-potential-biomarker-in-myasthenia-gravis,20,46501,1,1.htmlmetabolomics amino acid profiling myasthenia gravis diagnosis biomarker. |
| spellingShingle | Piotr Kośliński Łukasz Rzepiński Marcin Koba Marcin Gackowski Zdzisław Maciejek Amino acids levels as a potential biomarker in myasthenia gravis Folia Neuropathologica metabolomics amino acid profiling myasthenia gravis diagnosis biomarker. |
| title | Amino acids levels as a potential biomarker in myasthenia gravis |
| title_full | Amino acids levels as a potential biomarker in myasthenia gravis |
| title_fullStr | Amino acids levels as a potential biomarker in myasthenia gravis |
| title_full_unstemmed | Amino acids levels as a potential biomarker in myasthenia gravis |
| title_short | Amino acids levels as a potential biomarker in myasthenia gravis |
| title_sort | amino acids levels as a potential biomarker in myasthenia gravis |
| topic | metabolomics amino acid profiling myasthenia gravis diagnosis biomarker. |
| url | https://www.termedia.pl/Amino-acids-levels-as-a-potential-biomarker-in-myasthenia-gravis,20,46501,1,1.html |
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