Stressful Newborn Memories: Pre-Conceptual, In Utero, and Postnatal Events
Early-life stressful experiences are critical for plasticity and development, shaping adult neuroendocrine response and future health. Stress response is mediated by the autonomous nervous system and the hypothalamic–pituitary–adrenal (HPA) axis while various environmental stimuli are encoded via ep...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-04-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00220/full |
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| author | Zoe Papadopoulou Angeliki-Maria Vlaikou Angeliki-Maria Vlaikou Daniela Theodoridou Georgios S. Markopoulos Konstantina Tsoni Eleni Agakidou Vasiliki Drosou-Agakidou Christoph W. Turck Michaela D. Filiou Michaela D. Filiou Maria Syrrou |
| author_facet | Zoe Papadopoulou Angeliki-Maria Vlaikou Angeliki-Maria Vlaikou Daniela Theodoridou Georgios S. Markopoulos Konstantina Tsoni Eleni Agakidou Vasiliki Drosou-Agakidou Christoph W. Turck Michaela D. Filiou Michaela D. Filiou Maria Syrrou |
| author_sort | Zoe Papadopoulou |
| collection | DOAJ |
| description | Early-life stressful experiences are critical for plasticity and development, shaping adult neuroendocrine response and future health. Stress response is mediated by the autonomous nervous system and the hypothalamic–pituitary–adrenal (HPA) axis while various environmental stimuli are encoded via epigenetic marks. The stress response system maintains homeostasis by regulating adaptation to the environmental changes. Pre-conceptual and in utero stressors form the fetal epigenetic profile together with the individual genetic profile, providing the background for individual stress response, vulnerability, or resilience. Postnatal and adult stressful experiences may act as the definitive switch. This review addresses the issue of how preconceptual in utero and postnatal events, together with individual differences, shape future stress responses. Putative markers of early-life adverse effects such as prematurity and low birth weight are emphasized, and the epigenetic, mitochondrial, and genomic architecture regulation of such events are discussed. |
| first_indexed | 2024-12-12T21:47:27Z |
| format | Article |
| id | doaj.art-30c3fc9b7e44425cb9be1b1c1750bff5 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-12T21:47:27Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-30c3fc9b7e44425cb9be1b1c1750bff52022-12-22T00:10:53ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402019-04-011010.3389/fpsyt.2019.00220413902Stressful Newborn Memories: Pre-Conceptual, In Utero, and Postnatal EventsZoe Papadopoulou0Angeliki-Maria Vlaikou1Angeliki-Maria Vlaikou2Daniela Theodoridou3Georgios S. Markopoulos4Konstantina Tsoni5Eleni Agakidou6Vasiliki Drosou-Agakidou7Christoph W. Turck8Michaela D. Filiou9Michaela D. Filiou10Maria Syrrou11Laboratory of Biology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, GreeceLaboratory of Biology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, GreeceLaboratory of Biochemistry, Department of Biological Applications and Technology, School of Health Sciences, University of Ioannina, Ioannina, GreeceLaboratory of Biology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, GreeceLaboratory of Biology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece1st Department of Neonatology and Neonatal Intensive Care Unit, Medical Faculty, Aristotle University School of Health Sciences, Thessaloniki, Greece1st Department of Neonatology and Neonatal Intensive Care Unit, Medical Faculty, Aristotle University School of Health Sciences, Thessaloniki, Greece1st Department of Neonatology and Neonatal Intensive Care Unit, Medical Faculty, Aristotle University School of Health Sciences, Thessaloniki, GreeceMax Planck Institute of Psychiatry, Munich, GermanyLaboratory of Biochemistry, Department of Biological Applications and Technology, School of Health Sciences, University of Ioannina, Ioannina, GreeceMax Planck Institute of Psychiatry, Munich, GermanyLaboratory of Biology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, GreeceEarly-life stressful experiences are critical for plasticity and development, shaping adult neuroendocrine response and future health. Stress response is mediated by the autonomous nervous system and the hypothalamic–pituitary–adrenal (HPA) axis while various environmental stimuli are encoded via epigenetic marks. The stress response system maintains homeostasis by regulating adaptation to the environmental changes. Pre-conceptual and in utero stressors form the fetal epigenetic profile together with the individual genetic profile, providing the background for individual stress response, vulnerability, or resilience. Postnatal and adult stressful experiences may act as the definitive switch. This review addresses the issue of how preconceptual in utero and postnatal events, together with individual differences, shape future stress responses. Putative markers of early-life adverse effects such as prematurity and low birth weight are emphasized, and the epigenetic, mitochondrial, and genomic architecture regulation of such events are discussed.https://www.frontiersin.org/article/10.3389/fpsyt.2019.00220/fullstresspredispositionepigeneticslow birth weightindividualityearly-life stress |
| spellingShingle | Zoe Papadopoulou Angeliki-Maria Vlaikou Angeliki-Maria Vlaikou Daniela Theodoridou Georgios S. Markopoulos Konstantina Tsoni Eleni Agakidou Vasiliki Drosou-Agakidou Christoph W. Turck Michaela D. Filiou Michaela D. Filiou Maria Syrrou Stressful Newborn Memories: Pre-Conceptual, In Utero, and Postnatal Events Frontiers in Psychiatry stress predisposition epigenetics low birth weight individuality early-life stress |
| title | Stressful Newborn Memories: Pre-Conceptual, In Utero, and Postnatal Events |
| title_full | Stressful Newborn Memories: Pre-Conceptual, In Utero, and Postnatal Events |
| title_fullStr | Stressful Newborn Memories: Pre-Conceptual, In Utero, and Postnatal Events |
| title_full_unstemmed | Stressful Newborn Memories: Pre-Conceptual, In Utero, and Postnatal Events |
| title_short | Stressful Newborn Memories: Pre-Conceptual, In Utero, and Postnatal Events |
| title_sort | stressful newborn memories pre conceptual in utero and postnatal events |
| topic | stress predisposition epigenetics low birth weight individuality early-life stress |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00220/full |
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