Phenylalanine-Based AMPA Receptor Antagonist as the Anticonvulsant Agent with Neuroprotective Activity—In Vitro and In Vivo Studies

Phenylalanine-Based AMPA Receptor Antagonist as the Anticonvulsant Agent with Neuroprotective Activity—In Vitro and In Vivo Studies

Trying to meet the multitarget-directed ligands strategy, a series of previously described aryl-substituted phenylalanine derivatives, reported as competitive antagonists of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, were screened in vitro for their free-radical scavengin...

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Bibliographic Details
Main Authors: Gniewomir Latacz, Kinga Sałat, Anna Furgała-Wojas, Adrian Martyniak, Agnieszka Olejarz-Maciej, Ewelina Honkisz-Orzechowska, Ewa Szymańska
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Molecules
Subjects:
AMPA antagonist
phenylalanine
neuroprotection
antioxidant activity
FRAP
ORAC-FL
Online Access:https://www.mdpi.com/1420-3049/27/3/875

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