The potential role of N 7-methylguanosine (m7G) in cancer
Abstract N 7-methylguanosine (m7G), one of the most prevalent RNA modifications, has recently attracted significant attention. The m7G modification actively participates in biological and pathological functions by affecting the metabolism of various RNA molecules, including messenger RNA, ribosomal...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | Journal of Hematology & Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13045-022-01285-5 |
| _version_ | 1828216656332062720 |
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| author | Yuejun Luo Yuxin Yao Peng Wu Xiaohui Zi Nan Sun Jie He |
| author_facet | Yuejun Luo Yuxin Yao Peng Wu Xiaohui Zi Nan Sun Jie He |
| author_sort | Yuejun Luo |
| collection | DOAJ |
| description | Abstract N 7-methylguanosine (m7G), one of the most prevalent RNA modifications, has recently attracted significant attention. The m7G modification actively participates in biological and pathological functions by affecting the metabolism of various RNA molecules, including messenger RNA, ribosomal RNA, microRNA, and transfer RNA. Increasing evidence indicates a critical role for m7G in human disease development, especially cancer, and aberrant m7G levels are closely associated with tumorigenesis and progression via regulation of the expression of multiple oncogenes and tumor suppressor genes. Currently, the underlying molecular mechanisms of m7G modification in cancer are not comprehensively understood. Here, we review the current knowledge regarding the potential function of m7G modifications in cancer and discuss future m7G-related diagnostic and therapeutic strategies. |
| first_indexed | 2024-04-12T15:35:18Z |
| format | Article |
| id | doaj.art-30c48c008e534cf4b5e3e8c9c3f93213 |
| institution | Directory Open Access Journal |
| issn | 1756-8722 |
| language | English |
| last_indexed | 2024-04-12T15:35:18Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Hematology & Oncology |
| spelling | doaj.art-30c48c008e534cf4b5e3e8c9c3f932132022-12-22T03:26:58ZengBMCJournal of Hematology & Oncology1756-87222022-05-0115111410.1186/s13045-022-01285-5The potential role of N 7-methylguanosine (m7G) in cancerYuejun Luo0Yuxin Yao1Peng Wu2Xiaohui Zi3Nan Sun4Jie He5Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAbstract N 7-methylguanosine (m7G), one of the most prevalent RNA modifications, has recently attracted significant attention. The m7G modification actively participates in biological and pathological functions by affecting the metabolism of various RNA molecules, including messenger RNA, ribosomal RNA, microRNA, and transfer RNA. Increasing evidence indicates a critical role for m7G in human disease development, especially cancer, and aberrant m7G levels are closely associated with tumorigenesis and progression via regulation of the expression of multiple oncogenes and tumor suppressor genes. Currently, the underlying molecular mechanisms of m7G modification in cancer are not comprehensively understood. Here, we review the current knowledge regarding the potential function of m7G modifications in cancer and discuss future m7G-related diagnostic and therapeutic strategies.https://doi.org/10.1186/s13045-022-01285-5N 7-methylguanosine (m7G)RNA modificationRNA metabolismCancer |
| spellingShingle | Yuejun Luo Yuxin Yao Peng Wu Xiaohui Zi Nan Sun Jie He The potential role of N 7-methylguanosine (m7G) in cancer Journal of Hematology & Oncology N 7-methylguanosine (m7G) RNA modification RNA metabolism Cancer |
| title | The potential role of N 7-methylguanosine (m7G) in cancer |
| title_full | The potential role of N 7-methylguanosine (m7G) in cancer |
| title_fullStr | The potential role of N 7-methylguanosine (m7G) in cancer |
| title_full_unstemmed | The potential role of N 7-methylguanosine (m7G) in cancer |
| title_short | The potential role of N 7-methylguanosine (m7G) in cancer |
| title_sort | potential role of n 7 methylguanosine m7g in cancer |
| topic | N 7-methylguanosine (m7G) RNA modification RNA metabolism Cancer |
| url | https://doi.org/10.1186/s13045-022-01285-5 |
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