PIK3CA co-occurring mutations and copy-number gain in hormone receptor positive and HER2 negative breast cancer

PIK3CA co-occurring mutations and copy-number gain in hormone receptor positive and HER2 negative breast cancer

Abstract We aim to elucidate the prognostic value of PIK3CA mutations and copy number (CN) gain (PIK3CA-mut/gain) in hormone receptor-positive and HER2-negative (HR + /HER2−) breast cancer (BC). We analyzed primary HR + /HER2− BC from three publicly available datasets comprising over 2000 samples an...

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Bibliographic Details
Main Authors: Ilenia Migliaccio, Marta Paoli, Emanuela Risi, Chiara Biagioni, Laura Biganzoli, Matteo Benelli, Luca Malorni
Format: Article
Language:English
Published: Nature Portfolio 2022-02-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-022-00382-5

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