Vardenafil-Loaded Bilosomal Mucoadhesive Sponge for Buccal Delivery: Optimization, Characterization, and In Vivo Evaluation

Vardenafil-Loaded Bilosomal Mucoadhesive Sponge for Buccal Delivery: Optimization, Characterization, and In Vivo Evaluation

Vardenafil (VDF) is a relatively new phosphodiesterase-5 inhibitor that has limited oral bioavailability (≈15%). The objective of this study was to develop bilosome-based mucoadhesive buccal sponge for augmenting the oral bioavailability of VDF. VDF-loaded bilosomes were fabricated and optimized usi...

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Bibliographic Details
Main Authors: Mohammed F. Aldawsari, El-Sayed Khafagy, Hadil Faris Alotaibi, Amr Selim Abu Lila
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Polymers
Subjects:
bilosomes
buccal delivery
cGMP
mucoadhesive sponge
vardenafil
Online Access:https://www.mdpi.com/2073-4360/14/19/4184

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