Effects of chloroquine and sulfadoxine/pyrimethamine on gametocytes in patients with uncomplicated Plasmodium falciparum malaria in Colombia
The effect of antimalarials on gametocytes can influence transmission and the spread of drug resistance. In order to further understand this relationship, we determined the proportion of gametocyte carriers over time post-treatment in patients with uncomplicated Plasmodium falciparum malaria who wer...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2002-12-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762002000800026 |
| _version_ | 1827842579975110656 |
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| author | Lyda Osorio Beatriz E Ferro Carmen M Castillo |
| author_facet | Lyda Osorio Beatriz E Ferro Carmen M Castillo |
| author_sort | Lyda Osorio |
| collection | DOAJ |
| description | The effect of antimalarials on gametocytes can influence transmission and the spread of drug resistance. In order to further understand this relationship, we determined the proportion of gametocyte carriers over time post-treatment in patients with uncomplicated Plasmodium falciparum malaria who were treated with either chloroquine (CQ) or sulfadoxine/pyrimethamine (SP). The overall proportion of gametocyte carriers was high (85%) and not statistically significantly different between the CQ and SP treatment groups. However, an increased risk of carrying gametocytes on day 14 of follow up (1.26 95% CI 1.10-1.45) was found among patients having therapeutic failure to CQ compared with patients having an adequate therapeutic response. This finding confirms and extends reports of increased risk of gametocytaemia among CQ resistant P. falciparum. |
| first_indexed | 2024-03-12T08:11:38Z |
| format | Article |
| id | doaj.art-30c64089c59442bf9fc9115f69337bdf |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T08:11:38Z |
| publishDate | 2002-12-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-30c64089c59442bf9fc9115f69337bdf2023-09-02T19:06:46ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602002-12-019781221122310.1590/S0074-02762002000800026Effects of chloroquine and sulfadoxine/pyrimethamine on gametocytes in patients with uncomplicated Plasmodium falciparum malaria in ColombiaLyda OsorioBeatriz E FerroCarmen M CastilloThe effect of antimalarials on gametocytes can influence transmission and the spread of drug resistance. In order to further understand this relationship, we determined the proportion of gametocyte carriers over time post-treatment in patients with uncomplicated Plasmodium falciparum malaria who were treated with either chloroquine (CQ) or sulfadoxine/pyrimethamine (SP). The overall proportion of gametocyte carriers was high (85%) and not statistically significantly different between the CQ and SP treatment groups. However, an increased risk of carrying gametocytes on day 14 of follow up (1.26 95% CI 1.10-1.45) was found among patients having therapeutic failure to CQ compared with patients having an adequate therapeutic response. This finding confirms and extends reports of increased risk of gametocytaemia among CQ resistant P. falciparum.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762002000800026Plasmodium falciparumgametocytesantimalarial drugsmalariaColombia |
| spellingShingle | Lyda Osorio Beatriz E Ferro Carmen M Castillo Effects of chloroquine and sulfadoxine/pyrimethamine on gametocytes in patients with uncomplicated Plasmodium falciparum malaria in Colombia Memorias do Instituto Oswaldo Cruz Plasmodium falciparum gametocytes antimalarial drugs malaria Colombia |
| title | Effects of chloroquine and sulfadoxine/pyrimethamine on gametocytes in patients with uncomplicated Plasmodium falciparum malaria in Colombia |
| title_full | Effects of chloroquine and sulfadoxine/pyrimethamine on gametocytes in patients with uncomplicated Plasmodium falciparum malaria in Colombia |
| title_fullStr | Effects of chloroquine and sulfadoxine/pyrimethamine on gametocytes in patients with uncomplicated Plasmodium falciparum malaria in Colombia |
| title_full_unstemmed | Effects of chloroquine and sulfadoxine/pyrimethamine on gametocytes in patients with uncomplicated Plasmodium falciparum malaria in Colombia |
| title_short | Effects of chloroquine and sulfadoxine/pyrimethamine on gametocytes in patients with uncomplicated Plasmodium falciparum malaria in Colombia |
| title_sort | effects of chloroquine and sulfadoxine pyrimethamine on gametocytes in patients with uncomplicated plasmodium falciparum malaria in colombia |
| topic | Plasmodium falciparum gametocytes antimalarial drugs malaria Colombia |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762002000800026 |
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