Knockdown of lncRNA BDNF-AS inhibited the progression of multiple myeloma by targeting the miR-125a/b-5p-BCL2 axis

Knockdown of lncRNA BDNF-AS inhibited the progression of multiple myeloma by targeting the miR-125a/b-5p-BCL2 axis

Abstract Purpose This study aimed to explore the role of long non-coding RNA (lncRNA) BDNF-AS in the progression of multiple myeloma (MM). Methods The expression of BDNF-AS, miR-125a-5p, and miR-125b-5p in MM serum and cell lines were detected by quantitative reverse transcriptase PCR (qRT-PCR). The...

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Bibliographic Details
Main Authors: Min Chu, Yingchao Fan, Liting Wu, Xiaoyan Ma, Jinfeng Sao, Yonghua Yao, Wenfang Zhuang, Cui Zhang
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Immunity & Ageing
Subjects:
Multiple myeloma
BDNF-AS
miR-125a-5p
miR-125b-5p
Bcl-2
Proliferation
Online Access:https://doi.org/10.1186/s12979-021-00258-5

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