Aging Promotes Mitochondria-Mediated Apoptosis in Rat Hearts
Aging represents a major risk for developing cardiac disease, including heart failure. The gradual deterioration of cell quality control with aging leads to cell death, a phenomenon associated with mitochondrial dysfunction in the heart. Apoptosis is an important quality control process and a necess...
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MDPI AG
2020-09-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/10/9/178 |
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| author | Mi-Hyun No Youngju Choi Jinkyung Cho Jun-Won Heo Eun-Jeong Cho Dong-Ho Park Ju-Hee Kang Chang-Ju Kim Dae Yun Seo Jin Han Hyo-Bum Kwak |
| author_facet | Mi-Hyun No Youngju Choi Jinkyung Cho Jun-Won Heo Eun-Jeong Cho Dong-Ho Park Ju-Hee Kang Chang-Ju Kim Dae Yun Seo Jin Han Hyo-Bum Kwak |
| author_sort | Mi-Hyun No |
| collection | DOAJ |
| description | Aging represents a major risk for developing cardiac disease, including heart failure. The gradual deterioration of cell quality control with aging leads to cell death, a phenomenon associated with mitochondrial dysfunction in the heart. Apoptosis is an important quality control process and a necessary phenomenon for maintaining homeostasis and normal function of the heart. However, the mechanism of mitochondria-mediated apoptosis in aged hearts remains poorly understood. Here, we used male Fischer 344 rats of various ages, representing very young (1 month), young (4 months), middle-aged (12 months), and old (20 months) rats, to determine whether mitochondria-mediated apoptotic signals and apoptosis in the left ventricle of the heart are altered notably with aging. As the rats aged, the extramyocyte space and myocyte cross-sectional area in their left ventricle muscle increased, while the number of myocytes decreased. Additionally, mitochondrion-mediated apoptotic signals and apoptosis increased remarkably during aging. Therefore, our results demonstrate that aging promotes remarkable morphological changes and increases the degree of mitochondrion-mediated apoptosis in the left ventricle of rat hearts. |
| first_indexed | 2024-03-10T16:32:35Z |
| format | Article |
| id | doaj.art-30c73f989f8446978398867f31786be4 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T16:32:35Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-30c73f989f8446978398867f31786be42023-11-20T12:40:28ZengMDPI AGLife2075-17292020-09-0110917810.3390/life10090178Aging Promotes Mitochondria-Mediated Apoptosis in Rat HeartsMi-Hyun No0Youngju Choi1Jinkyung Cho2Jun-Won Heo3Eun-Jeong Cho4Dong-Ho Park5Ju-Hee Kang6Chang-Ju Kim7Dae Yun Seo8Jin Han9Hyo-Bum Kwak10Department of Biomedical Science, Program in Biomedical Science & Engineering, Department of Kinesiology, Inha University, Incheon 22212, KoreaInstitute of Sports and Arts Convergence, Inha University, Incheon 22212, KoreaInstitute of Sports and Arts Convergence, Inha University, Incheon 22212, KoreaDepartment of Biomedical Science, Program in Biomedical Science & Engineering, Department of Kinesiology, Inha University, Incheon 22212, KoreaDepartment of Biomedical Science, Program in Biomedical Science & Engineering, Department of Kinesiology, Inha University, Incheon 22212, KoreaDepartment of Biomedical Science, Program in Biomedical Science & Engineering, Department of Kinesiology, Inha University, Incheon 22212, KoreaInstitute of Sports and Arts Convergence, Inha University, Incheon 22212, KoreaDepartment of Physiology, College of Medicine, Kyung Hee University, Seoul 02447, KoreaNational Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, KoreaNational Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, KoreaDepartment of Biomedical Science, Program in Biomedical Science & Engineering, Department of Kinesiology, Inha University, Incheon 22212, KoreaAging represents a major risk for developing cardiac disease, including heart failure. The gradual deterioration of cell quality control with aging leads to cell death, a phenomenon associated with mitochondrial dysfunction in the heart. Apoptosis is an important quality control process and a necessary phenomenon for maintaining homeostasis and normal function of the heart. However, the mechanism of mitochondria-mediated apoptosis in aged hearts remains poorly understood. Here, we used male Fischer 344 rats of various ages, representing very young (1 month), young (4 months), middle-aged (12 months), and old (20 months) rats, to determine whether mitochondria-mediated apoptotic signals and apoptosis in the left ventricle of the heart are altered notably with aging. As the rats aged, the extramyocyte space and myocyte cross-sectional area in their left ventricle muscle increased, while the number of myocytes decreased. Additionally, mitochondrion-mediated apoptotic signals and apoptosis increased remarkably during aging. Therefore, our results demonstrate that aging promotes remarkable morphological changes and increases the degree of mitochondrion-mediated apoptosis in the left ventricle of rat hearts.https://www.mdpi.com/2075-1729/10/9/178aging heartBcl-2 familymitochondriaprogrammed cell death |
| spellingShingle | Mi-Hyun No Youngju Choi Jinkyung Cho Jun-Won Heo Eun-Jeong Cho Dong-Ho Park Ju-Hee Kang Chang-Ju Kim Dae Yun Seo Jin Han Hyo-Bum Kwak Aging Promotes Mitochondria-Mediated Apoptosis in Rat Hearts Life aging heart Bcl-2 family mitochondria programmed cell death |
| title | Aging Promotes Mitochondria-Mediated Apoptosis in Rat Hearts |
| title_full | Aging Promotes Mitochondria-Mediated Apoptosis in Rat Hearts |
| title_fullStr | Aging Promotes Mitochondria-Mediated Apoptosis in Rat Hearts |
| title_full_unstemmed | Aging Promotes Mitochondria-Mediated Apoptosis in Rat Hearts |
| title_short | Aging Promotes Mitochondria-Mediated Apoptosis in Rat Hearts |
| title_sort | aging promotes mitochondria mediated apoptosis in rat hearts |
| topic | aging heart Bcl-2 family mitochondria programmed cell death |
| url | https://www.mdpi.com/2075-1729/10/9/178 |
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