Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer
The unfolded protein response (UPR) promotes cell survival in cancers with hyperactive ER stress response. Here the authors show that CARM1, an arginine methyltransferase, controls the IRE1α/XBP1 pathway of the UPR and the inhibition of this pathway can inhibit growth in CARM1 expressing ovarian can...
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Bibliographic Details
| Main Authors: |
Jianhuang Lin,
Heng Liu,
Takeshi Fukumoto,
Joseph Zundell,
Qingqing Yan,
Chih-Hang Anthony Tang,
Shuai Wu,
Wei Zhou,
Dajiang Guo,
Sergey Karakashev,
Chih-Chi Andrew Hu,
Kavitha Sarma,
Andrew V. Kossenkov,
Rugang Zhang |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-09-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-25684-3
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