Future Antimicrobials: Natural and Functionalized Phenolics
With incidence of antimicrobial resistance rising globally, there is a continuous need for development of new antimicrobial molecules. Phenolic compounds having a versatile scaffold that allows for a broad range of chemical additions; they also exhibit potent antimicrobial activities which can be en...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/3/1114 |
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| author | Andrei Lobiuc Naomi-Eunicia Pavăl Ionel I. Mangalagiu Roxana Gheorghiță Gabriel-Ciprian Teliban Dorina Amăriucăi-Mantu Vasile Stoleru |
| author_facet | Andrei Lobiuc Naomi-Eunicia Pavăl Ionel I. Mangalagiu Roxana Gheorghiță Gabriel-Ciprian Teliban Dorina Amăriucăi-Mantu Vasile Stoleru |
| author_sort | Andrei Lobiuc |
| collection | DOAJ |
| description | With incidence of antimicrobial resistance rising globally, there is a continuous need for development of new antimicrobial molecules. Phenolic compounds having a versatile scaffold that allows for a broad range of chemical additions; they also exhibit potent antimicrobial activities which can be enhanced significantly through functionalization. Synthetic routes such as esterification, phosphorylation, hydroxylation or enzymatic conjugation may increase the antimicrobial activity of compounds and reduce minimal concentrations needed. With potent action mechanisms interfering with bacterial cell wall synthesis, DNA replication or enzyme production, phenolics can target multiple sites in bacteria, leading to a much higher sensitivity of cells towards these natural compounds. The current review summarizes some of the most important knowledge on functionalization of natural phenolic compounds and the effects on their antimicrobial activity. |
| first_indexed | 2024-03-11T09:33:09Z |
| format | Article |
| id | doaj.art-30c9d765a2114cc08b655d7b8a88cee0 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T09:33:09Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-30c9d765a2114cc08b655d7b8a88cee02023-11-16T17:27:50ZengMDPI AGMolecules1420-30492023-01-01283111410.3390/molecules28031114Future Antimicrobials: Natural and Functionalized PhenolicsAndrei Lobiuc0Naomi-Eunicia Pavăl1Ionel I. Mangalagiu2Roxana Gheorghiță3Gabriel-Ciprian Teliban4Dorina Amăriucăi-Mantu5Vasile Stoleru6Faculty of Medicine and Biological Sciences, “Ştefan cel Mare” University, 720229 Suceava, RomaniaFaculty of Medicine and Biological Sciences, “Ştefan cel Mare” University, 720229 Suceava, RomaniaFaculty of Chemistry, “Alexandru Ioan Cuza” University, 700506 Iasi, RomaniaFaculty of Medicine and Biological Sciences, “Ştefan cel Mare” University, 720229 Suceava, RomaniaDepartment of Horticulture Technologies, “Ion Ionescu de la Brad” University of Life Sciences, 700490 Iasi, RomaniaFaculty of Chemistry, “Alexandru Ioan Cuza” University, 700506 Iasi, RomaniaDepartment of Horticulture Technologies, “Ion Ionescu de la Brad” University of Life Sciences, 700490 Iasi, RomaniaWith incidence of antimicrobial resistance rising globally, there is a continuous need for development of new antimicrobial molecules. Phenolic compounds having a versatile scaffold that allows for a broad range of chemical additions; they also exhibit potent antimicrobial activities which can be enhanced significantly through functionalization. Synthetic routes such as esterification, phosphorylation, hydroxylation or enzymatic conjugation may increase the antimicrobial activity of compounds and reduce minimal concentrations needed. With potent action mechanisms interfering with bacterial cell wall synthesis, DNA replication or enzyme production, phenolics can target multiple sites in bacteria, leading to a much higher sensitivity of cells towards these natural compounds. The current review summarizes some of the most important knowledge on functionalization of natural phenolic compounds and the effects on their antimicrobial activity.https://www.mdpi.com/1420-3049/28/3/1114flavonoidstanninslignansminimal inhibitory concentrationesterificationalkylation |
| spellingShingle | Andrei Lobiuc Naomi-Eunicia Pavăl Ionel I. Mangalagiu Roxana Gheorghiță Gabriel-Ciprian Teliban Dorina Amăriucăi-Mantu Vasile Stoleru Future Antimicrobials: Natural and Functionalized Phenolics Molecules flavonoids tannins lignans minimal inhibitory concentration esterification alkylation |
| title | Future Antimicrobials: Natural and Functionalized Phenolics |
| title_full | Future Antimicrobials: Natural and Functionalized Phenolics |
| title_fullStr | Future Antimicrobials: Natural and Functionalized Phenolics |
| title_full_unstemmed | Future Antimicrobials: Natural and Functionalized Phenolics |
| title_short | Future Antimicrobials: Natural and Functionalized Phenolics |
| title_sort | future antimicrobials natural and functionalized phenolics |
| topic | flavonoids tannins lignans minimal inhibitory concentration esterification alkylation |
| url | https://www.mdpi.com/1420-3049/28/3/1114 |
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