Dietary inflammatory index in relation to the progression of hepatic steatosis and liver fibrosis: evaluation by elastography/Fibroscan
Abstract One of the proposed mechanisms by which nutrition influences the progression of hepatic steatosis to fibrosis is inflammation. The study investigated how the inflammatory potential of the diet affects the risk of liver damage in patients with nonalcoholic fatty liver disease (NAFLD), a cond...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-04-01
|
| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12876-024-03209-8 |
| _version_ | 1797209266621251584 |
|---|---|
| author | Mahsa Miryan Sameeah Abdulrahman Rashid Jamshid Gholizadeh Navashenaq Davood Soleimani Mohsen Nematy Jalal Moludi |
| author_facet | Mahsa Miryan Sameeah Abdulrahman Rashid Jamshid Gholizadeh Navashenaq Davood Soleimani Mohsen Nematy Jalal Moludi |
| author_sort | Mahsa Miryan |
| collection | DOAJ |
| description | Abstract One of the proposed mechanisms by which nutrition influences the progression of hepatic steatosis to fibrosis is inflammation. The study investigated how the inflammatory potential of the diet affects the risk of liver damage in patients with nonalcoholic fatty liver disease (NAFLD), a condition where fat accumulates in the liver. This cross-sectional study included 170 outpatients with newly diagnosed NAFLD. This study used a device called Fibroscan® to measure the degree of liver fibrosis, which is the scarring of the liver tissue due to chronic inflammation. The study also used a tool called the Dietary Inflammatory Index (DII) to measure the inflammatory potential of the diet based on the intake of different foods and nutrients. In the findings of the study, patients with more severe fat accumulation in the liver (hepatic steatosis) had higher DII scores, meaning they had more inflammatory diets. The study also found that higher DII scores were associated with higher weight and body mass index (BMI). One standard deviation (SD) increase in DII scores was associated with a 0.29 kilopascal (95% CI: 0.10–0.44; P-value 0.001) increase in the mean liver stiffness, an indicator of liver fibrosis. The study concluded that patients with higher DII scores had a higher risk of developing liver fibrosis than those with lower DII scores, even after adjusting for confounding factors (odds ratio: 5.89; P-value: 0.001). The study suggested that eating less inflammatory foods may help prevent or slow down the progression of hepatic steatosis and liver in patients with NAFLD. |
| first_indexed | 2024-04-24T09:51:58Z |
| format | Article |
| id | doaj.art-30cbbed0aceb40479b3790bb12b55468 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-04-24T09:51:58Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-30cbbed0aceb40479b3790bb12b554682024-04-14T11:18:09ZengBMCBMC Gastroenterology1471-230X2024-04-012411710.1186/s12876-024-03209-8Dietary inflammatory index in relation to the progression of hepatic steatosis and liver fibrosis: evaluation by elastography/FibroscanMahsa Miryan0Sameeah Abdulrahman Rashid1Jamshid Gholizadeh Navashenaq2Davood Soleimani3Mohsen Nematy4Jalal Moludi5Student Research Committee, Kermanshah University of Medical SciencesDepartment of surgery, college of medicine, Hawler Medical UniversityNoncommunicable Diseases Research Center, Bam University of Medical SciencesNutritional Sciences Department, School of Nutrition Sciences and Food Technology, Kermanshah University of Medical SciencesDepartment of Nutrition, Faculty of Medicine, Mashhad University of Medical SciencesNutritional Sciences Department, School of Nutrition Sciences and Food Technology, Kermanshah University of Medical SciencesAbstract One of the proposed mechanisms by which nutrition influences the progression of hepatic steatosis to fibrosis is inflammation. The study investigated how the inflammatory potential of the diet affects the risk of liver damage in patients with nonalcoholic fatty liver disease (NAFLD), a condition where fat accumulates in the liver. This cross-sectional study included 170 outpatients with newly diagnosed NAFLD. This study used a device called Fibroscan® to measure the degree of liver fibrosis, which is the scarring of the liver tissue due to chronic inflammation. The study also used a tool called the Dietary Inflammatory Index (DII) to measure the inflammatory potential of the diet based on the intake of different foods and nutrients. In the findings of the study, patients with more severe fat accumulation in the liver (hepatic steatosis) had higher DII scores, meaning they had more inflammatory diets. The study also found that higher DII scores were associated with higher weight and body mass index (BMI). One standard deviation (SD) increase in DII scores was associated with a 0.29 kilopascal (95% CI: 0.10–0.44; P-value 0.001) increase in the mean liver stiffness, an indicator of liver fibrosis. The study concluded that patients with higher DII scores had a higher risk of developing liver fibrosis than those with lower DII scores, even after adjusting for confounding factors (odds ratio: 5.89; P-value: 0.001). The study suggested that eating less inflammatory foods may help prevent or slow down the progression of hepatic steatosis and liver in patients with NAFLD.https://doi.org/10.1186/s12876-024-03209-8DietNonalcoholic fatty liver diseaseNAFLDLiver fibrosisInflammation |
| spellingShingle | Mahsa Miryan Sameeah Abdulrahman Rashid Jamshid Gholizadeh Navashenaq Davood Soleimani Mohsen Nematy Jalal Moludi Dietary inflammatory index in relation to the progression of hepatic steatosis and liver fibrosis: evaluation by elastography/Fibroscan BMC Gastroenterology Diet Nonalcoholic fatty liver disease NAFLD Liver fibrosis Inflammation |
| title | Dietary inflammatory index in relation to the progression of hepatic steatosis and liver fibrosis: evaluation by elastography/Fibroscan |
| title_full | Dietary inflammatory index in relation to the progression of hepatic steatosis and liver fibrosis: evaluation by elastography/Fibroscan |
| title_fullStr | Dietary inflammatory index in relation to the progression of hepatic steatosis and liver fibrosis: evaluation by elastography/Fibroscan |
| title_full_unstemmed | Dietary inflammatory index in relation to the progression of hepatic steatosis and liver fibrosis: evaluation by elastography/Fibroscan |
| title_short | Dietary inflammatory index in relation to the progression of hepatic steatosis and liver fibrosis: evaluation by elastography/Fibroscan |
| title_sort | dietary inflammatory index in relation to the progression of hepatic steatosis and liver fibrosis evaluation by elastography fibroscan |
| topic | Diet Nonalcoholic fatty liver disease NAFLD Liver fibrosis Inflammation |
| url | https://doi.org/10.1186/s12876-024-03209-8 |
| work_keys_str_mv | AT mahsamiryan dietaryinflammatoryindexinrelationtotheprogressionofhepaticsteatosisandliverfibrosisevaluationbyelastographyfibroscan AT sameeahabdulrahmanrashid dietaryinflammatoryindexinrelationtotheprogressionofhepaticsteatosisandliverfibrosisevaluationbyelastographyfibroscan AT jamshidgholizadehnavashenaq dietaryinflammatoryindexinrelationtotheprogressionofhepaticsteatosisandliverfibrosisevaluationbyelastographyfibroscan AT davoodsoleimani dietaryinflammatoryindexinrelationtotheprogressionofhepaticsteatosisandliverfibrosisevaluationbyelastographyfibroscan AT mohsennematy dietaryinflammatoryindexinrelationtotheprogressionofhepaticsteatosisandliverfibrosisevaluationbyelastographyfibroscan AT jalalmoludi dietaryinflammatoryindexinrelationtotheprogressionofhepaticsteatosisandliverfibrosisevaluationbyelastographyfibroscan |