Serum Urate Levels and Ultrasound Characteristics of Carotid Atherosclerosis across Obesity Phenotypes
Background: Existing evidence suggests a close link among high levels of serum urate (SU), obesity and carotid atherosclerosis. The aim of the present study was to evaluate the interrelations between SU levels and carotid atherosclerosis in subjects with different obesity phenotypes. Methods: In thi...
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| Format: | Article |
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MDPI AG
2023-07-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/7/1897 |
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| author | Daniela Efremova Natalia Ciobanu Danu Glavan Pavel Leahu Renata Racila Tatiana Bălănuță Alexandru Matei Maria Vasilieva Cristina Cheptea Paula Bîtcă Cristina Damian Ana Bondarciuc Irina Bejenari Adelina Cojocaru Diana Manea Mihail Ciocanu Eremei Zota Dumitru Ciolac Stanislav A. Groppa |
| author_facet | Daniela Efremova Natalia Ciobanu Danu Glavan Pavel Leahu Renata Racila Tatiana Bălănuță Alexandru Matei Maria Vasilieva Cristina Cheptea Paula Bîtcă Cristina Damian Ana Bondarciuc Irina Bejenari Adelina Cojocaru Diana Manea Mihail Ciocanu Eremei Zota Dumitru Ciolac Stanislav A. Groppa |
| author_sort | Daniela Efremova |
| collection | DOAJ |
| description | Background: Existing evidence suggests a close link among high levels of serum urate (SU), obesity and carotid atherosclerosis. The aim of the present study was to evaluate the interrelations between SU levels and carotid atherosclerosis in subjects with different obesity phenotypes. Methods: In this study, a total of 2076 subjects (mean age 48.1 ± 13.1 years; 1307 women) were recruited: 59 with general obesity, 616 with central obesity, 715 with mixed (general–central) obesity and 686 non-obese. Anthropometric measurements, vascular risk factors, blood biochemistry analysis (including SU levels), and carotid ultrasound were performed. Ultrasound assessment included evaluation of intima-media thickness (IMT) and plaque characteristics, including number, total area and type (vulnerable vs. stable) of plaques. Results: After adjustment for potential confounders, the highest levels of SU were observed in subjects with mixed obesity, followed by subjects with central obesity, general obesity and the non-obese (309.4 ± 82.2 vs. 301.2 ± 73.1 vs. 272.9 ± 61.8 vs. 234.2 ± 59.8 μmol/L, respectively; F = 149.2, post hoc <i>p</i> < 0.001). Similarly, subjects with mixed and central obesity presented higher values of IMT compared to subjects with general obesity and the non-obese (0.68 ± 0.16 vs. 0.67 ± 0.16 vs. 0.62 ± 0.14 vs. 0.57 ± 0.13 mm, respectively; F = 54.2, post hoc <i>p</i> < 0.001). No difference in number, total area and type of plaques among obesity groups were attested (all <i>p</i> > 0.05). Significantly higher IMT values were observed in subjects with increased SU levels compared to subjects with normal SU levels (0.70 ± 0.10 vs. 0.62 ± 0.14 mm, <i>p</i> = 0.02) only within the central obesity group. Increasing levels of SU were associated with a higher frequency of increased IMT only in subjects with central obesity (OR 1.033, 95% CI 1.025–1.041). Similarly, SU levels yielded a satisfactory performance in detecting subjects with increased IMT (AUC 0.65, 95% CI 0.50–0.73, subjects with carotid plaques (0.62, 95% CI 0.55–0.68) and subjects with vulnerable plaque types (0.68, 0.59–0.76) only within the central obesity group. Conclusions: Among the studied obesity types, the association between SU levels and markers of carotid atherosclerosis was of particular significance in subjects with central obesity. |
| first_indexed | 2024-03-11T01:16:24Z |
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| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T01:16:24Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-30d0449e091e469d9c3b0cfb64acbf282023-11-18T18:26:33ZengMDPI AGBiomedicines2227-90592023-07-01117189710.3390/biomedicines11071897Serum Urate Levels and Ultrasound Characteristics of Carotid Atherosclerosis across Obesity PhenotypesDaniela Efremova0Natalia Ciobanu1Danu Glavan2Pavel Leahu3Renata Racila4Tatiana Bălănuță5Alexandru Matei6Maria Vasilieva7Cristina Cheptea8Paula Bîtcă9Cristina Damian10Ana Bondarciuc11Irina Bejenari12Adelina Cojocaru13Diana Manea14Mihail Ciocanu15Eremei Zota16Dumitru Ciolac17Stanislav A. Groppa18Department of Neurology, Institute of Emergency Medicine, 2004 Chisinau, MoldovaDepartment of Neurology, Institute of Emergency Medicine, 2004 Chisinau, MoldovaDepartment of Neurology, Institute of Emergency Medicine, 2004 Chisinau, MoldovaDepartment of Neurology, Institute of Emergency Medicine, 2004 Chisinau, MoldovaDepartment of Neurology, Institute of Emergency Medicine, 2004 Chisinau, MoldovaDepartment of Neurology, Institute of Emergency Medicine, 2004 Chisinau, MoldovaDepartment of Neurology, Institute of Emergency Medicine, 2004 Chisinau, MoldovaDepartment of Neurology, Institute of Emergency Medicine, 2004 Chisinau, MoldovaDepartment of Neurology, Institute of Emergency Medicine, 2004 Chisinau, MoldovaDepartment of Neurology, Institute of Emergency Medicine, 2004 Chisinau, MoldovaDepartment of Neurology, Institute of Emergency Medicine, 2004 Chisinau, MoldovaDepartment of Neurology, Institute of Emergency Medicine, 2004 Chisinau, MoldovaDepartment of Neurology, Institute of Emergency Medicine, 2004 Chisinau, MoldovaDepartment of Neurology, Institute of Emergency Medicine, 2004 Chisinau, MoldovaDepartment of Neurology, Institute of Emergency Medicine, 2004 Chisinau, MoldovaDepartment of Neurology, Institute of Emergency Medicine, 2004 Chisinau, MoldovaDepartment of Neurology, Institute of Emergency Medicine, 2004 Chisinau, MoldovaDepartment of Neurology, Institute of Emergency Medicine, 2004 Chisinau, MoldovaDepartment of Neurology, Institute of Emergency Medicine, 2004 Chisinau, MoldovaBackground: Existing evidence suggests a close link among high levels of serum urate (SU), obesity and carotid atherosclerosis. The aim of the present study was to evaluate the interrelations between SU levels and carotid atherosclerosis in subjects with different obesity phenotypes. Methods: In this study, a total of 2076 subjects (mean age 48.1 ± 13.1 years; 1307 women) were recruited: 59 with general obesity, 616 with central obesity, 715 with mixed (general–central) obesity and 686 non-obese. Anthropometric measurements, vascular risk factors, blood biochemistry analysis (including SU levels), and carotid ultrasound were performed. Ultrasound assessment included evaluation of intima-media thickness (IMT) and plaque characteristics, including number, total area and type (vulnerable vs. stable) of plaques. Results: After adjustment for potential confounders, the highest levels of SU were observed in subjects with mixed obesity, followed by subjects with central obesity, general obesity and the non-obese (309.4 ± 82.2 vs. 301.2 ± 73.1 vs. 272.9 ± 61.8 vs. 234.2 ± 59.8 μmol/L, respectively; F = 149.2, post hoc <i>p</i> < 0.001). Similarly, subjects with mixed and central obesity presented higher values of IMT compared to subjects with general obesity and the non-obese (0.68 ± 0.16 vs. 0.67 ± 0.16 vs. 0.62 ± 0.14 vs. 0.57 ± 0.13 mm, respectively; F = 54.2, post hoc <i>p</i> < 0.001). No difference in number, total area and type of plaques among obesity groups were attested (all <i>p</i> > 0.05). Significantly higher IMT values were observed in subjects with increased SU levels compared to subjects with normal SU levels (0.70 ± 0.10 vs. 0.62 ± 0.14 mm, <i>p</i> = 0.02) only within the central obesity group. Increasing levels of SU were associated with a higher frequency of increased IMT only in subjects with central obesity (OR 1.033, 95% CI 1.025–1.041). Similarly, SU levels yielded a satisfactory performance in detecting subjects with increased IMT (AUC 0.65, 95% CI 0.50–0.73, subjects with carotid plaques (0.62, 95% CI 0.55–0.68) and subjects with vulnerable plaque types (0.68, 0.59–0.76) only within the central obesity group. Conclusions: Among the studied obesity types, the association between SU levels and markers of carotid atherosclerosis was of particular significance in subjects with central obesity.https://www.mdpi.com/2227-9059/11/7/1897serum urateintima-media thicknesscarotid plaquesobesity phenotype |
| spellingShingle | Daniela Efremova Natalia Ciobanu Danu Glavan Pavel Leahu Renata Racila Tatiana Bălănuță Alexandru Matei Maria Vasilieva Cristina Cheptea Paula Bîtcă Cristina Damian Ana Bondarciuc Irina Bejenari Adelina Cojocaru Diana Manea Mihail Ciocanu Eremei Zota Dumitru Ciolac Stanislav A. Groppa Serum Urate Levels and Ultrasound Characteristics of Carotid Atherosclerosis across Obesity Phenotypes Biomedicines serum urate intima-media thickness carotid plaques obesity phenotype |
| title | Serum Urate Levels and Ultrasound Characteristics of Carotid Atherosclerosis across Obesity Phenotypes |
| title_full | Serum Urate Levels and Ultrasound Characteristics of Carotid Atherosclerosis across Obesity Phenotypes |
| title_fullStr | Serum Urate Levels and Ultrasound Characteristics of Carotid Atherosclerosis across Obesity Phenotypes |
| title_full_unstemmed | Serum Urate Levels and Ultrasound Characteristics of Carotid Atherosclerosis across Obesity Phenotypes |
| title_short | Serum Urate Levels and Ultrasound Characteristics of Carotid Atherosclerosis across Obesity Phenotypes |
| title_sort | serum urate levels and ultrasound characteristics of carotid atherosclerosis across obesity phenotypes |
| topic | serum urate intima-media thickness carotid plaques obesity phenotype |
| url | https://www.mdpi.com/2227-9059/11/7/1897 |
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