Effect of Convallaria majalis on Kidney Function
Objective: To evaluate the effect o f Convallaria majalis on kidney function. The kidneys are vital organs thatperform a variety of important functions in our body. Primary and secondary causes o f kidney diseases producechanges in glomerular filtration rate that m ay leads to kidney failure. Bloo...
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| Format: | Article |
| Language: | English |
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Dow University of Health Sciences
2010-12-01
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| Series: | Journal of the Dow University of Health Sciences |
| Subjects: | |
| Online Access: | https://www.jduhs.com/index.php/jduhs/article/view/1329 |
| _version_ | 1827939543291002880 |
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| author | Tooba Lateef Hafsa Rukash Faiza Bibi Muhammad Bilal Azmi Shamim Akhtar Qureshi |
| author_facet | Tooba Lateef Hafsa Rukash Faiza Bibi Muhammad Bilal Azmi Shamim Akhtar Qureshi |
| author_sort | Tooba Lateef |
| collection | DOAJ |
| description | Objective:
To evaluate the effect o f Convallaria majalis on kidney function. The kidneys are vital organs thatperform a variety of important functions in our body. Primary and secondary causes o f kidney diseases producechanges in glomerular filtration rate that m ay leads to kidney failure. Blood parameters such as uric acid andcreatinine are used to assess kidney function. C. majalis (CM) commonly called as Lily o f the valley is aHomoeopathic remedy having valuable action on heart and also has diuretic action.
Methods:
In the present study, the effect o f CM was investigated on serum uric acid and creatinine, byadministrating orally 70% alcoholic extract o f CM (10 and 50 mg/kg), simvastatin (20 mg/kg), 0.05%dimethylsulphooxide (DMSO, 1ml/kg) and distilled w ater (1ml/kg) to test (A & B groups), positive, negativeand control rabbits respectively for 14 days consecutively once in a day.
Results:
Out of two tested doses, 10 mg/kg o f CM produced significant decrease in uric acid levels from 10.978.40mg/dL in test rabbits (Test A) when compared with control, negative & positive control groups (p<0.05).However, the same dose o f extract showed no effect on serum creatinine levels.
Conclusion:
According to the data, alcoholic extract o f CM @ 10mg/kg was found as a significant hypouricemicagent.
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| first_indexed | 2024-03-13T08:55:09Z |
| format | Article |
| id | doaj.art-30d0a04bf56747ab88688e0cd6637c91 |
| institution | Directory Open Access Journal |
| issn | 1995-2198 2410-2180 |
| language | English |
| last_indexed | 2024-03-13T08:55:09Z |
| publishDate | 2010-12-01 |
| publisher | Dow University of Health Sciences |
| record_format | Article |
| series | Journal of the Dow University of Health Sciences |
| spelling | doaj.art-30d0a04bf56747ab88688e0cd6637c912023-05-29T03:11:35ZengDow University of Health SciencesJournal of the Dow University of Health Sciences1995-21982410-21802010-12-0143Effect of Convallaria majalis on Kidney FunctionTooba Lateef0Hafsa Rukash1Faiza Bibi2Muhammad Bilal Azmi3Shamim Akhtar Qureshi4Department of Biochemistry, Jinnah University for Women, Karachi-74600, Pakistan.Department of Biochemistry, Jinnah University for Women, Karachi-74600, Pakistan.Department of Biochemistry, Jinnah University for Women, Karachi-74600, Pakistan.Dow College of Pharmacy, Dow University of Health Sciences, Karachi-74200, Pakistan.Department of Biochemistry, University of Karachi, Karachi- 75270, Pakistan.Objective: To evaluate the effect o f Convallaria majalis on kidney function. The kidneys are vital organs thatperform a variety of important functions in our body. Primary and secondary causes o f kidney diseases producechanges in glomerular filtration rate that m ay leads to kidney failure. Blood parameters such as uric acid andcreatinine are used to assess kidney function. C. majalis (CM) commonly called as Lily o f the valley is aHomoeopathic remedy having valuable action on heart and also has diuretic action. Methods: In the present study, the effect o f CM was investigated on serum uric acid and creatinine, byadministrating orally 70% alcoholic extract o f CM (10 and 50 mg/kg), simvastatin (20 mg/kg), 0.05%dimethylsulphooxide (DMSO, 1ml/kg) and distilled w ater (1ml/kg) to test (A & B groups), positive, negativeand control rabbits respectively for 14 days consecutively once in a day. Results: Out of two tested doses, 10 mg/kg o f CM produced significant decrease in uric acid levels from 10.978.40mg/dL in test rabbits (Test A) when compared with control, negative & positive control groups (p<0.05).However, the same dose o f extract showed no effect on serum creatinine levels. Conclusion: According to the data, alcoholic extract o f CM @ 10mg/kg was found as a significant hypouricemicagent. https://www.jduhs.com/index.php/jduhs/article/view/1329Glomerular filtrationkidneyuric acidcreatininehypouricemic activity |
| spellingShingle | Tooba Lateef Hafsa Rukash Faiza Bibi Muhammad Bilal Azmi Shamim Akhtar Qureshi Effect of Convallaria majalis on Kidney Function Journal of the Dow University of Health Sciences Glomerular filtration kidney uric acid creatinine hypouricemic activity |
| title | Effect of Convallaria majalis on Kidney Function |
| title_full | Effect of Convallaria majalis on Kidney Function |
| title_fullStr | Effect of Convallaria majalis on Kidney Function |
| title_full_unstemmed | Effect of Convallaria majalis on Kidney Function |
| title_short | Effect of Convallaria majalis on Kidney Function |
| title_sort | effect of convallaria majalis on kidney function |
| topic | Glomerular filtration kidney uric acid creatinine hypouricemic activity |
| url | https://www.jduhs.com/index.php/jduhs/article/view/1329 |
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